|
The document reports on the analysis of FC-143 content in serum and liver samples from a 90-day subacute toxicity study in rhesus monkeys, indicating adverse effects at higher dosage levels compared to a previous rat study, with notable differences in accumulation between species.
|
2000 |
AR226-0448
|
xqQr8ymOgq6XedDOEKMjDdzm |
2 |
|
The document reports on a study conducted by Southern Research Institute to determine the percent protein binding of perfluorohexane sulfonate, perfluorooctane sulfonate, and perfluorooctanoate in human, rat, and monkey plasma, as well as various human-derived plasma protein fractions.
|
2000 |
AR226-1354
|
J32RwgxJdRv3Qr3OMor8560OO |
47 |
|
3M submitted a TSCA 8(e) notice to the EPA regarding a 2-year rat feeding study on N-Ethyl perfluorooctylsulfonamido ethanol (N-EtFOSE), indicating a statistically significant increase in benign liver tumors in high dose female rats, corroborating earlier findings from 1988.
|
2000 |
AR226-0974
|
dnBojOo7J8XLJyo3DGV8V7V4e |
2 |
|
The document is a correspondence from Mary Dominiak of the EPA discussing the proposed Significant New Use Rule on PFOS, a chemical of concern in AFFF, and providing information on how to submit comments on the rule.
|
2000 |
AR226-0975
|
v6xeD2XoyBRm04rv5LKpbYMyb |
8 |
|
3M submitted a draft Initial Assessment Report on Perfluorooctane Sulfonic Acid (PFOS) to the EPA, detailing available data and evaluations as part of their ongoing dialogue regarding fluorochemistry.
|
2000 |
AR226-0976
|
NeBZ0rkr91BqLodZ9gnvK8jeQ |
2 |
|
This document is a cover letter from 3M to the EPA, enclosing a draft initial assessment report on perfluorooctane sulfonic acid (PFOS) that evaluates its exposure and biological effects, indicating that current data suggests no adverse health effects associated with human serum levels or environmental concentrations of PFOS.
|
2000 |
AR226-0977
|
5X09egN1NVRb2BpqeROgKzLN |
2 |
|
This is a letterhead cover page from 3M Specialty Materials, dated December 22, 2000, with no analytical content retained in the OCR.
|
2000 |
AR226-0979
|
LJZ34NojkJwLNOx3D47gaYjO3 |
7 |
|
The document is a final report from Covance Laboratories detailing a study on the L5178Y TK +/- Mouse Lymphoma Forward Mutation Assay conducted with N-EtFOSE (3M Study No.: T-6316.12), submitted to 3M Corporate Toxicology, and confirms compliance with Good Laboratory Practice regulations.
|
2000 |
AR226-0983
|
KJddBpGaQEM8N1k41jBZ7RVKQ |
30 |
|
The document is a report amendment regarding Protocol 418-009 for a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of N-EtFOSE in rats, issued by Primedica Corporation, which includes a correction to the dosage administration notation without affecting the study results.
|
2000 |
AR226-0986
|
6xwOELk5pLQeDDxg97dZnZbE |
3 |
|
The document is a final report on a toxicokinetic study of Perfluorooctane Sulfonamide (PFOSA) conducted by 3M, which found that PFOSA is metabolized to PFOS in rats, with PFOSA showing a liver half-life of 5.2 days and serum half-life of less than 4 days.
|
2000 |
AR226-0993
|
o9vYvkz775MKYR4XMOdwdoRER |
18 |
|
The document contains summaries of various toxicology and pharmacokinetic studies related to perfluorooctanoic acid (PFOA) and its derivatives, specifically focusing on studies conducted by 3M and Riker Laboratories involving rabbits and rats.
|
2000 |
AR226-0453
|
qknMVv1KEVp0zDjm5bervQLBn |
121 |
|
The document is a final report from 3M Environmental Laboratory detailing a single-dose dermal absorption/toxicity study of a t-butyl ammonium salt of perfluorooctanoate (PFOA) in rabbits, which found that liver and serum levels of total organic fluorine were below practical quantitation limits, indicating minimal absorption.
|
2000 |
AR226-0454
|
yk7k3Mn00E8wv0rakM6m0d44E |
233 |
|
The document details toxicology studies on PFOA (referred to as T-2998CoC) conducted by Riker Laboratories, Inc. for 3M, including an oral rangefinder study in pregnant rats to establish dosing levels for subsequent teratology studies.
|
2000 |
AR226-0462
|
7OJyYYdaQD2Qgz43pgv7EVwOE |
9 |
|
The document contains attachments related to toxicology studies and epidemiological investigations on PFOA, focusing on health status and mortality among workers exposed to perfluorooctanoic acid at various production plants, including summaries of multiple studies conducted by different researchers.
|
2000 |
AR226-0469
|
ZJoDBDewBKXmJdqdr8rR1VdqY |
9 |
|
The document discusses toxicology studies on PFOS and N-EtFOSE, highlighting severe maternal toxicity and reduced fetal body weights observed in a study conducted by Covance, as reported in correspondence from E. Marshall Johnson to William C. McCormick, III.
|
2000 |
AR226-0529
|
gaXzZEE5Gk6wMoDBGa8J0LRMJ |
3 |
|
This document includes attachments to a letter dated May 25, 2000, discussing toxicology studies and other information on PFOA, along with a letter from E. Marshall Johnson to William C. McCormick, III, regarding teratology studies on PFOS and ethyl FOSE, dated November 12, 1982, which concludes that the test substances pose no unique hazard to development.
|
2000 |
AR226-0531
|
ga7LXODdb4rmy7aXrRErmR8pG |
3 |
|
3M submitted a supplemental TSCA Section 8(e) notice to the EPA regarding N-Ethyl Perfluorooctyl Sulfonamido Ethanol (N-EtFOSE) and Perfluorooctane Sulfonate (PFOS), including an amended final report on a two-generation rat reproduction study that found no significant effects on pup survival or growth at a specific dosage
|
2000 |
AR226-0555
|
RaQYM72RLgeBY0ZKXmZawebQX |
4 |
|
The document is a final report amendment regarding a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of N-EtFOSE in rats, indicating a correction to the dosage administration notation without affecting the study results.
|
2000 |
AR226-1363
|
R93VqLz4MDnbJwnxZLxyyLVB |
3 |
|
The document discusses laboratory-scale thermal degradation studies of perfluorooctanesulfonate (PFOS) and related substances, including FC-807A and FC-1395, to evaluate their potential environmental impact and sources of PFOS.
|
2000 |
AR226-1366
|
375zwg6qyOV91ovEBd2mBqq7y |
13 |
|
This document is a draft initial assessment report prepared by 3M on perfluorooctane sulfonic acid (PFOS) and its salts, detailing identity, exposure, and environmental considerations related to the substance.
|
2000 |
AR226-0978
|
gaYG5Ve7L605zoG7NMQozLq6V |
381 |
|
This is a cover page from Pace Analytical Services, Inc. for the 3M Multi-city Food Study, prepared under contract for 3M with project number 1039292.
|
2000 |
AR226-1698
|
kDJwDaa06DdDm0vkMwRLwX90B |
1 |
|
This report summarizes the effectiveness of a 3M wastewater treatment system using Granular Activated Carbon (GAC) to reduce PFOA concentrations to below detection limits, demonstrating consistent low effluent concentrations and an estimated adsorption capacity of approximately 6.0 mg PFOA per gram of activated carbon.
|
2000 |
AR226-1699
|
DGw2QVpe9RR6r2023X5LR8GXa |
6 |
|
The document reports on a study conducted by Dr. U. Noack-Laboratorium on the toxicity of 1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro to terrestrial plants, specifically focusing on seedling emergence, in compliance with
|
2000 |
AR226-1433
|
nL2b2vbgerBdyLN3MwXzRNe2 |
51 |
|
The document is a final report on a cross-fostering study of PFOS (perfluorooctane sulfonate) in rats, detailing the study's methods, results, and conclusions as part of a regulatory compliance effort.
|
2000 |
AR226-0553
|
44xQb5qmm4zGxMp7Xz6mBvM1N |
257 |
|
The document is a final report from Boston University detailing a study funded by 3M, which found that perfluorooctanesulfonate (PFOS) activates both PPARa and PPARy receptors, indicating its potential role in altering lipid metabolism and other physiological processes.
|
2000 |
AR226-1723
|
RJ7jGOVkrVw892QGLxe2VwvGk |
55 |
|
The T-6295.28 Final Report details a study sponsored by 3M to analyze liver enzymes, glycogen levels, and PFOS concentration in liver samples from rats treated with varying doses of Perfluorooctane Sulfonate (PFOS) during a one-generation reproduction study.
|
2000 |
AR226-1725
|
5byMXopxe7ZwXZNZraMGJRVnN |
13 |
|
The document is a toxicological summary of a dietary acute study on perfluorooctanesulfonate (PFOS) conducted on mallards, detailing the test substance's purity, methods, and experimental design, including exposure and recovery periods.
|
2000 |
AR226-1734
|
7eJQeLrZeryo1wJGjNkpB1bj |
11 |
|
The document summarizes a dietary chronic pilot reproductive study on the effects of perfluorooctanesulfonate (PFOS) on adult mallards, detailing the experimental design, exposure levels, and evaluation of health and reproductive outcomes over a 20-week period.
|
2000 |
AR226-1737
|
pp8gvqRb7r1zw7rV82gJYpZYB |
12 |
|
The document is a final report of a pilot reproduction study on PFOS conducted with mallards, submitted to 3M Corporation by Wildlife International, Ltd., and completed on December 18, 2003, in compliance with Good Laboratory Practice standards.
|
2000 |
AR226-1738
|
2Nrd5qKXLjGGXm47r4YQkXrJN |
125 |
|
The document is a final report of a pilot reproduction study on PFOS conducted with mallards by Wildlife International, Ltd. for 3M Corporation, completed on December 18, 2003, and compliant with Good Laboratory Practice Standards.
|
2000 |
AR226-1742
|
ba61x2Kevq1Q6emYjqKDRJBQg |
125 |
|
The document is a Toxicological Summary of a dietary acute study on Perfluorooctanesulfonate (PFOS) conducted on Northern Bobwhite quail, detailing changes in the purity of the test substance and the methodology used in the study.
|
2000 |
AR226-1746
|
gDY0vMR674gv6X5jw7kq1RMbq |
11 |
|
This document is a toxicological summary of a dietary acute study on perfluorooctanesulfonate (PFOS) conducted on Northern Bobwhite quail, detailing the test substance's purity, methods used, and the study's timeline and design.
|
2000 |
AR226-1749
|
LXMk8oL0Rv1L8R8Eg27OmZoQ |
11 |
|
This document is the final report of a pilot reproduction study on PFOS conducted by Wildlife International, Ltd. for 3M Corporation, which was completed on December 18, 2003, and adhered to Good Laboratory Practice Standards.
|
2000 |
AR226-1750
|
NEGzo7nd6ORZ14zrJJGbEVnmV |
125 |
|
This document is a correspondence from DuPont Haskell Laboratory to the EPA, providing a summary of the U.S. uses of Ammonium Perfluorooctanoate (APFO), including its role as a fluoropolymer reaction aid, release data, industrial hygiene information, and employee blood data, while clarifying that DuPont does not manufacture APFO but purchases it from an external supplier
|
2000 |
AR226-1555
|
jg2934erwmLDBY5XED67KdJ0R |
14 |
|
The document discusses internal communications among DuPont employees regarding the preparation of a standby statement related to a 3M announcement on PFOS/PFOA, emphasizing the need for accuracy in media responses and clarifying the use of the statement.
|
2000 |
AR226-1666
|
9JbqY184n0Ep4vOEbn0r7gNy3 |
2 |
|
DuPont is seeking expert assistance to defend against a lawsuit from a farmer in West Virginia alleging health and environmental impacts related to PFOA from a non-hazardous landfill, despite their assessment indicating negligible risks to the farmer's cows.
|
2000 |
AR226-1676
|
BorzJ5xOer8Xa6XpLVDRezmm |
1 |
|
3M is submitting a supplemental notice to the EPA regarding studies on the detection of perfluorooctanesulfonate (PFOS) in tissue samples from various animal species, highlighting initial screening data on PFOS distribution in biota using high-performance liquid chromatography-tandem mass spectrometry.
|
1999 |
AR226-0541
|
RjXdE1Zdoxrm9xDww17QZmDmB |
4 |
|
The document is a correspondence from Larry R. Zobel of 3M to the EPA, summarizing findings from rat teratology studies on 3M fluorochemicals, indicating that while FC-95 did not cause skeletal abnormalities, a mixture of perfluoroethanol derivatives resulted in significant fetal malformations, including cleft palates and kidney issues at high doses.
|
1999 |
AR226-0542
|
waqQ1GxzqQY883gZv6GV26E |
5 |
|
3M is sending the EPA two papers on perfluorooctane sulfonate (PFOS) and organic fluorochemistry, along with a note about a forthcoming exposure assessment, to facilitate a discussion on these topics.
|
1999 |
AR226-0546
|
pDG43dDnoLKbRpEpKD2gdwbB |
1 |
|
The document discusses the science of organic fluorochemistry, detailing 3M Company's history and methods in synthesizing perfluorinated compounds through the Simons Electro-Chemical Fluorination process.
|
1999 |
AR226-0547
|
bOXJNyv3kyO03EEVrqOrd6X3 |
12 |
|
3M submitted an overview paper to the EPA detailing the manufacture, use, distribution, and environmental release of sulfonyl-based fluorochemicals, including PFOS, along with a preliminary life-cycle assessment of exposure pathways and ongoing stewardship initiatives.
|
1999 |
AR226-0549
|
6EBEyLVGN88oEbkrmX8d6V1o |
2 |
|
This document by 3M summarizes the biological effects, health risks, and future research plans related to perfluorooctane sulfonate (PFOS), highlighting its presence in human serum samples at levels of tens of parts per billion.
|
1999 |
AR226-0548
|
aJV8p8nvjBJag7K8LRqbMwVa9 |
135 |
|
This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater alga Anabaena flos-aquae, sponsored by 3M Corporation and conducted by Wildlife International, Ltd.
|
1999 |
AR226-0186
|
yp5oZ784nZ25kDM1q03gOXQp3 |
16 |
|
The document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater diatom Navicula pelliculosa, to be conducted by Wildlife International, Ltd. for 3M Corporation.
|
1999 |
AR226-0187
|
gD7OXJXZJ91ZvbjRb4a8L8LKN |
17 |
|
This document outlines a protocol for a 96-hour toxicity test of PFOS using the marine diatom Skeletonema costatum, sponsored by 3M Corporation and conducted by Wildlife International, Ltd.
|
1999 |
AR226-0188
|
ykVqmZE5yM31a5DOyrynZyzQE |
17 |
|
The document outlines a protocol for a seven-day toxicity test of PFOS using duckweed (Lemna gibba G3) conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines to assess ecological effects.
|
1999 |
AR226-0189
|
dDMbJkn4zG4za3v0xw6yaa2R5 |
18 |
|
This document is a report prepared by 3M Company on May 26, 1999, providing an overview of the use, distribution, and environmental release of sulfonyl-based fluorochemicals, intended to inform exposure assessment and product stewardship initiatives.
|
1999 |
AR226-0550
|
pBxQkBGD7DyRMrBMDdErVaz0E |
350 |
|
The document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M, to assess its oral absorption, clearance, and metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes.
|
1999 |
AR226-0209
|
1ywqr0EmbJB61dV7v5Q0NrkVm |
6 |
|
The document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA
|
1999 |
AR226-0215
|
km1gaYBYJxQbDpxQBeO9REZnV |
14 |
|
This document is a final report on a pharmacokinetic study of PFOS conducted in rats, detailing the study's methods, results, and compliance with regulatory standards.
|
1999 |
AR226-0565
|
VJBVmBvvDrNL2wgObQ1zJRGXp |
172 |
|
This document outlines the protocol for a pharmacokinetic recovery study of potassium perfluorooctane sulfonate (PFOS) in rats, conducted by 3M Environmental Technology and Safety Services to determine PFOS levels in liver and serum specimens.
|
1999 |
AR226-0566
|
NGdeXkz65Q7zYMQMb9brromMp |
25 |
|
This document outlines a protocol for an oral pharmacokinetic study of potassium perfluorooctane sulfonate (PFOS) in rats, sponsored by 3M, aimed at determining PFOS levels in liver and serum specimens.
|
1999 |
AR226-0567
|
YjGNyJ72QbbMJ4Kv1nRbJYYk8 |
24 |
|
This document is the final report of a pharmacokinetic recovery study of PFOS conducted in rats, detailing the study's methods, results, and conclusions.
|
1999 |
AR226-0568
|
Z4JnMnmO6z2wDBVgVzeQyRbYY |
160 |
|
This document is a final report on a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of PFOS conducted in rats, detailing the study's methods, results, and conclusions.
|
1999 |
AR226-0563
|
aJz93wv3rdONV9X2k8VvY3XMb |
645 |
|
The document summarizes a two-generation reproduction study of PFOS (Perfluorooctanesulfonate) conducted on rats, which assessed the effects of various dose levels on fertility, development, and postnatal reproduction, with findings indicating no deaths in the Fo generation animals.
|
1999 |
AR226-0569
|
XQgzBBGgvemZn700BKppae3G |
11 |
|
This analytical laboratory report details the determination of the presence and concentration of Perfluorooctanesulfonate (PFOS) in the serum of Sprague-Dawley rats exposed to potassium perfluorooctanesulfonate via gavage, conducted by 3M Environmental Laboratory.
|
1999 |
AR226-0570
|
EqMozRYwLaYJ2r7qqejMB4Y6n |
113 |
|
The document is a pathology report detailing an ancillary study on the pharmacokinetics of PFOS in CRL:CDBR VAF/Plus rats, indicating no significant ultrastructural differences in liver and lung tissues between treated and control groups.
|
1999 |
AR226-0572
|
JvE81EJ73DJd9jnRRz4OooJ12 |
74 |
|
The document is a final report for an oral (gavage) cross-fostering study of PFOS in rats, conducted under study number T-6295.13, detailing the methods, results, and conclusions of the research.
|
1999 |
AR226-0571
|
wgLo66D4wYRpp2rjKwzZ4OabJ |
257 |
|
The document is a letter from the EPA to Dr. William A. Weppner of 3M discussing the development of a product stewardship Memorandum of Understanding regarding perfluorooctane sulfonyl fluoride, indicating that further review of health effects and exposure assessments is needed before determining the appropriateness of such an agreement.
|
1999 |
AR226-0640
|
ByxXqgrDwbeJXqMQR5839ayKk |
20 |
|
The document discusses an expert review of mouse lymphoma cell mutation testing on 3M product T-6906, indicating that the study was deemed technically inadequate and insufficient to draw valid conclusions regarding its mutagenic activity, necessitating a repeat of the study under acceptable test conditions.
|
1999 |
AR226-0254
|
M4axXgoqgNnwERqVOVK6jZ14x |
3 |
|
This is a final field report prepared by Battelle for a multi-city study analyzing trace-level FC residuals in Mobile, Alabama, and Pensacola, Florida, under Project Number N100672-01.
|
1999 |
AR226-0677
|
MJwd6458pD3OMz2zN1q6YjmqM |
17 |
|
This is a field report from Battelle regarding a multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on trace-level analysis of specific FC residuals and human exposure assessment.
|
1999 |
AR226-0678
|
qkd6no7BvNq6eBbgX4MVLjN1K |
16 |
|
This is a final field report from Battelle (Project Number N100672-01) detailing the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, focusing on the sampling of FOSE-based fluorochemical residuals for environmental and human exposure assessment.
|
1999 |
AR226-0679
|
M44OampNdLq439N4N3MR92qKy |
16 |
|
This report evaluates the statistical quality of 12 data sources on serum PFOS levels in non-occupational human populations, revealing a geometric mean PFOS blood level of 28.2 ppb, with only pooled serum from U.S. blood banks deemed defensible for analysis.
|
1999 |
AR226-0036
|
jmd6p7J0pm0ypeYX5Nezb886Q |
10 |
|
The document reports the vapor pressure of perfluorooctanesulfonate (PFOS), produced by 3M Company, as 3.31 x 10^-4 Pa at 20°C, determined using the Spinning Rotor Gauge method, with a purity of 90.49%.
|
1999 |
AR226-0047
|
Rp5x3jk7MJ5xzQgDJkZn6x1kk |
2 |
|
The document reports on a study conducted by Wildlife International, Ltd. for 3M Company to determine the n-octanol/water partition coefficient of perfluorooctanesulfonate (PFOS), which was ultimately deemed infeasible due to the formation of an emulsion during testing.
|
1999 |
AR226-0050
|
pBryL6NdrbRKk35wa7yNKJpZa |
3 |
|
The document reports on a study conducted by Wildlife International Ltd. to determine the vapor pressure of PFOS using the spinning rotor gauge method, sponsored by 3M Corporation, and completed on May 5, 1999, while noting some deviations from Good Laboratory Practice Standards.
|
1999 |
AR226-0048
|
E1z2ZxnVgY6rGX7QbdvkogMx |
26 |
|
The document details a method developed by Dr. Richard Purdy of 3M and Don Mackay for determining the air/water partition coefficient of perfluorooctanesulfonate (PFOS), although it notes that there is no standardized methodology for regulatory purposes.
|
1999 |
AR226-0051
|
9Jg071dyJwz9GgjQJJ3B5ZMbe |
10 |
|
This document reports on a study conducted by Wildlife International Ltd. to determine the water solubility of PFOS using the shake flask method, sponsored by 3M Corporation, and outlines compliance with Good Laboratory Practice standards.
|
1999 |
AR226-0052
|
3JE4E6D1521gL6X7173Qv866J |
35 |
|
The document reports on a water solubility test for Perfluorooctanesulfonate (PFOS) conducted by 3M, finding an overall mean solubility concentration of 519 mg/L in NANOpure water at 20°C.
|
1999 |
AR226-0054
|
2jmXq1EzM0VvdNgxGD9L8V0w7 |
22 |
|
The document presents a fugacity modeling study of perfluorooctanesulfonate (PFOS), conducted by Don Mackay, indicating that PFOS tends to remain in water when released, with slow degradation and significant persistence in the environment.
|
1999 |
AR226-0060
|
jmR4k62658X3Z7M3gK6M6bvEZ |
4 |
|
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using standard EPA methodology and a conservative uncertainty factor.
|
1999 |
AR226-0071
|
MKd1Jzq9qR1wkmbYjZkkEXx9 |
6 |
|
This is a field report from Battelle detailing the multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on the collection of samples for trace-level analysis of specific FC residuals.
|
1999 |
AR226-0073
|
rB6MaL9RRL0RNra0aavyrNwEV |
16 |
|
The document outlines a review of field sampling procedures conducted by Battelle during a city survey in Columbus, Georgia, as part of the Multi-City Human Exposure Assessment Study, focusing on the appropriateness of sampling techniques for fluorochemicals, including PFOA and PFOS, in various environmental sources.
|
1999 |
AR226-0072
|
pmYnYb2dGaO9kebYnNMrEw4wd |
22 |
|
This is a final field report from Battelle for the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, under Project Number N100672-01, focusing on the analysis of FOSE-based fluorochemical residuals.
|
1999 |
AR226-0074
|
jBQy0R59ggMr09d9q2VBqJoz9 |
16 |
|
The document is a final field report detailing the multi-city study conducted by Battelle in Mobile, Alabama, and Pensacola, Florida, focusing on the sampling and analysis of perfluorinated compounds, including PFOA and PFOS, as part of Project Number N100672-01.
|
1999 |
AR226-0075
|
0gQ1NEp1k3RND7vXrngV9Qd1b |
17 |
|
This document is an amendment to the Quality Assurance Project Plan for the Empirical Human Exposure Assessment Multi-City Study, detailing changes to sampling protocols, including the addition of labeling for 'Trip Blank' samples.
|
1999 |
AR226-0077
|
3ek21mqNggyX9ngp17rZow3DD |
23 |
|
This document details an acute toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the fish species Pimephales promelas, using a sample from 3M with a purity of 90.49%, following OECD and OPPTS guidelines, to determine LC50 values over a 96-hour exposure period.
|
1999 |
AR226-0082
|
6bDmn3OKRjvDB2bEQBeEayL5R |
4 |
|
The document reports on a toxicity study of perfluorooctanesulfonate (PFOS) conducted by 3M, which assessed its effects on the aquatic plant species Selenastrum capricornutum, finding a purity of 90.49% and detailing the testing methodology and conditions.
|
1999 |
AR226-0084
|
8R9o55LmoQRNedORdnQnLr6Da |
6 |
|
The document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted under OECD guidelines, with a purity of 90.49% and results indicating the EC50 values calculated for the test.
|
1999 |
AR226-0086
|
0x6dpQdwZLKnB4rXNxyxwBd |
4 |
|
The document details a study on the acute toxicity of perfluorooctanesulfonate (PFOS) sourced from 3M, assessing its impact on shell growth in the eastern oyster (Crassostrea virginica) over a 96-hour exposure period, with a purity of 90.49% confirmed through various analytical techniques.
|
1999 |
AR226-0088
|
KJdNr46ybR8BxM9mrZgXVNg76 |
4 |
|
This document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the freshwater mussel species Unio complanatus, conducted under EPA guidelines, with a test substance purity of 90.49% and results analyzed for LC50 values.
|
1999 |
AR226-0090
|
Znqn3oOqjZVeJe6L8E59VGDxd |
4 |
|
The document details an OECD 209 activated sludge respiration inhibition test conducted on perfluorooctanesulfonate (PFOS) sourced from 3M, with a purity of 90.49%, to assess its impact on dissolved oxygen concentrations in wastewater treatment conditions.
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1999 |
AR226-0092
|
3JORLdwBNoyY6OQLaY7jjm3Kn |
3 |
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This document is an amended final report on a 96-hour shell deposition test conducted by Wildlife International Ltd. for 3M Corporation, evaluating the ecological effects of PFOS on the Eastern oyster (Crassostrea virginica), completed on August 11, 1999, and amended on April 26, 2000.
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1999 |
AR226-0089
|
ybkZbLmR7eaX0RVXXL5xXo5Y6 |
56 |
|
This document is an amended final report of a 96-hour static acute toxicity test conducted by Wildlife International Ltd. on PFOS using the freshwater mussel (Unio complamatus), sponsored by 3M Corporation, and it outlines compliance with Good Laboratory Practice standards.
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1999 |
AR226-0091
|
jjX1RQgXJMQKx9vyY54eb13O |
59 |
|
The document details an acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, to determine the LC50 values over a 96-hour exposure period.
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1999 |
AR226-0094
|
1g9wQnObboZLGMV06dnjRNqrj |
4 |
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The document details a chronic toxicity study of perfluorooctanesulfonate (PFOS) conducted on early life stages of fish (Pimephales promelas) using a 47-day flow-through method, with a purity of 90.49% and statistical analyses to assess significant differences from control groups.
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1999 |
AR226-0096
|
dQdzp9pzbVeVGKpLaoEODvV7b |
5 |
|
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) on the freshwater invertebrate Daphnia magna, conducted by Wildlife International, Ltd., which assessed survival, reproduction, and growth over a 21-day exposure period, with a purity of the test substance determined to be 90.49%.
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1999 |
AR226-0098
|
rwE496GLxrJbGzjv12NKv1mG |
6 |
|
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, and outlines the methods and statistical analyses used to evaluate the effects of PFOS over a 35-day exposure period.
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1999 |
AR226-0100
|
85Q77BKnmKJVE1yKwRp8vYdb5 |
7 |
|
The document is a final report on an early life-stage toxicity test of PFOS conducted with the fathead minnow (Pimephales promelas) by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and compliant with Good Laboratory Practice standards.
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1999 |
AR226-0097
|
EdZDD8Q08aGQXqaBNad4LNqZn |
88 |
|
This document details a dietary acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on northern bobwhite quail, using a sample from 3M with a purity of 90.49%, to assess its effects under controlled conditions.
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1999 |
AR226-0104
|
zzrp85E4mY1k1rDppzeXN0NE6 |
9 |
|
The document is a final report on a semi-static life-cycle toxicity test of PFOS conducted with the cladoceran Daphnia magna, submitted by Wildlife International Ltd. to 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization and stability determination.
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1999 |
AR226-0099
|
jgLRBkm3eL0KXDBZdypQ26BD5 |
93 |
|
The document is a final report on a flow-through life-cycle toxicity test of PFOS conducted with the saltwater mysid (Mysidopsis bahia) by Wildlife International, Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization.
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1999 |
AR226-0101
|
V33Rry7KExX2pgrbMOgnwGMQg |
76 |
|
The document details a dietary LC50 study on PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and adheres to Good Laboratory Practice standards, although the test substance characterization did not fully comply with GLP.
|
1999 |
AR226-0103
|
X8an4DmMQnZoJboaqbD9O4ZB4 |
89 |
|
The document is a final report by Covance Laboratories on a study investigating chromosomal aberrations in human whole blood lymphocytes exposed to PFOS, submitted to 3M Corporate Toxicology, and conducted in compliance with EPA regulations.
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1999 |
AR226-0131
|
R2j5NYemr8raaa0v0YxB45rLV |
41 |
|
This document is a second draft cell proliferation report detailing a 104-week dietary chronic toxicity and carcinogenicity study of perfluorooctane sulfonic acid potassium salt (PFOS) in rats, prepared by Pathology Associates International for 3M.
|
1999 |
AR226-0142
|
LJR782eygN68dg86Vdy3LnqqQ |
26 |
|
The document details a pathology review of a PFOS six-month toxicity study in monkeys, concluding that the deaths of two high-dose male monkeys were likely related to compound toxicity, with one showing signs of acute pneumonia and the other exhibiting liver changes indicative of toxicity.
|
1999 |
AR226-0150
|
066nDbpVNyj2pkmd0L9YeLjEV |
2 |
|
The document is a pathology report detailing the findings from a 26-week toxicity study of perfluorooctane sulfonic acid (PFOS) in cynomolgus monkeys, which revealed hepatocellular vacuolation and hypertrophy, along with increased lipid droplets and glycogen in liver cells.
|
1999 |
AR226-0149
|
dDYmGnDnQExo7YLGpbe7Gb5rq |
60 |
|
The document discusses a study by Kendall B. Wallace, Ph.D., investigating the inhibitory effects of selected perfluorochemicals, including PFOA and PFOS, on mitochondrial fatty acid oxidation using rat liver mitochondria.
|
1999 |
AR226-0170
|
q3mOea9jzdwNkg7RvK58jNjVn |
4 |
|
This document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M Specialty Chemicals Division, to assess its oral absorption, clearance, and metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes.
|
1999 |
AR226-0180
|
aDxY64G8JgOjjJ72VgDzgwLJ9 |
6 |