|
The document reports on a 14-day feeding study conducted by E. I. du Pont de Nemours and Company to evaluate the repeated dose oral toxicity of H-19683 in male mice, finding significant decreases in body weight and increases in liver weights at the highest dose of 3000 ppm.
|
1995 |
AR226-3018
|
r2QJYRzvz42Jpp5ZV9R81Drv |
23 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the acute eye irritation potential of the substance H-21209 in rabbits, finding it to be a mild eye irritant.
|
1995 |
AR226-3024
|
rBOpbzvmRevMxvMywwR2zmgjV |
10 |
|
The document reports a study conducted by E. I. du Pont de Nemours and Company to determine the approximate lethal dose (ALD) of the substance H-21209 in male rats, finding it to be greater than 11,000 mg/kg, indicating very low toxicity.
|
1995 |
AR226-3026
|
gbJjvELRoZXLpy16K30j4yyDL |
5 |
|
The document reports on a 100-person human patch test conducted by Biosearch, Inc. for E. I. du Pont de Nemours and Company to evaluate the potential irritation and delayed hypersensitivity of three test materials, including H-21273 and H-21274, with findings indicating their stability during the study.
|
1995 |
AR226-3023
|
2JJge4jxLk6m92d4Vag755Oq6 |
32 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company, which found that the substance H-21209 exhibited mild skin irritation in rabbits, with slight erythema and no edema observed after exposure.
|
1995 |
AR226-3027
|
XR45rj6zV43J6dRqKorZ4Y91y |
8 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the skin corrosion potential of the substance H-21333 using the In Vitro CorrositexTM assay, which determined it to be corrosive and assigned it to Packing Group III.
|
1995 |
AR226-3031
|
qaE9Zbg6rwryVBvDOgZ3OmGOE |
4 |
|
The document reports on a gene mutation assay conducted in vitro using Chinese hamster V79 cells, as part of CCR Project 509800, confirming compliance with Good Laboratory Practice standards, but does not specify findings related to PFOA or PFOS.
|
1995 |
AR226-3029
|
0J3RaOB694jo0eYp9ygG9bVMR |
29 |
|
The document is a test report certifying that the mutagenicity assay for PFOA conducted in Chinese hamster V79 cells by CCR Cytotest Cell Research GmbH was completed in compliance with Good Laboratory Practice principles.
|
1995 |
AR226-3030
|
8R2YQZzwbDmxwyeZdZOn91bxa |
29 |
|
This document appears to be a laboratory report detailing the acute and chronic toxicity assessments of two fluorotelomer surfactants on algae, indicating that both compounds have EC50 values greater than 100 mg/L and a lowest NOEC of 25 mg/L for the anionic surfactant.
|
1995 |
AR226-3366
|
2mGdNVwxYdkXj3O9m6bVb5ra |
1 |
|
The document evaluates the aquatic toxicity of two perfluorinated surfactants in early life stage tests with rainbow trout, indicating they exhibit low to moderate toxicity.
|
1995 |
AR226-3367
|
JrBVB6wvm6z8aYQDqV3KmRomO |
1 |
|
The document describes an in vitro chromosome aberration study conducted by BioReliance for DuPont, focusing on human peripheral blood lymphocytes, and outlines compliance with various regulatory guidelines while noting exceptions regarding the characterization and stability of test articles.
|
1995 |
AR226-3181
|
EvvQR5EkqqgKvvBK6M7GqXgXj |
40 |
|
The document outlines a bacterial reverse mutation test (Study No. H-24889) conducted by BioReliance for DuPont, assessing the genotoxicity of a test article under compliance with various regulatory guidelines, although it notes exceptions regarding the determination of control article characteristics and stability.
|
1995 |
AR226-3180
|
LgjgZQk20GppKvyGwpJ2G9rab |
63 |
|
The document reports on a biodegradation test for a mixture containing perfluorooctanesulfonate (PFOS) conducted by MDS Environmental Services at the request of 3M Canada, revealing high Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD) values, but lacking sufficient data quality and characterization of the sample.
|
1995 |
AR226-0691
|
yqpRXj950xk1293Qd48xVyMX |
3 |
|
The document details an acute toxicity test conducted on fathead minnows (Pimephales promelas) using a mixture containing 3% perfluorooctanesulfonate (PFOS) and other components, following OECD Guideline 203, to assess the toxicity of the test substance over a 96-hour exposure period.
|
1995 |
AR226-0693
|
g2Zjpz4v1DbGnXB0gB3kg6zqG |
7 |
|
The document reports on a toxicity test of a mixture containing perfluorooctanesulfonate (PFOS) conducted on the aquatic plant species Selenastrum capricomutum, using OECD guidelines, but notes that the data may not accurately reflect the toxicity of the fluorochemical component due to incomplete characterization of impurities.
|
1995 |
AR226-0694
|
Z45NgwXGNnaM1z19kjn95QDq0 |
6 |
|
The document describes a nitrification inhibition test conducted on a mixture containing perfluorooctanesulfonate (PFOS) and other components, indicating that the test aimed to evaluate the impact of PFOS on microbial nitrification using activated sludge from a wastewater treatment plant.
|
1995 |
AR226-0765
|
3QBy0XgRO7DxBQaJbKkop3Z20 |
8 |
|
The document reports on a nitrification inhibition test conducted on a mixture containing perfluorooctanesulfonate (PFOS) produced by 3M, indicating that the EC50 for the test substance is greater than 498 mg/L, suggesting low toxicity to nitrifying microorganisms.
|
1995 |
AR226-0766
|
0Jd23GJaagLK3Bpo9enzo0Ngk |
6 |
|
The document details an acute toxicity test conducted on fathead minnows (Pimephales promelas) using a mixture containing 1% perfluorooctanesulfonate (PFOS) and other components, following standard guidelines to assess the toxicity of the test substance.
|
1995 |
AR226-0767
|
x5aJg2BZdRLGgkmrLraZ23V9g |
9 |
|
The document reports on a toxicity study of a mixture containing perfluorooctanesulfonate (PFOS) conducted on the freshwater algae species Selenastrum capricomutum, following OECD guidelines, to assess its effects on algal cell counts and growth rates over a 96-hour exposure period.
|
1995 |
AR226-0864
|
vyYQeG7bDx2qJgzngvNzXOK69 |
6 |
|
This document details an acute toxicity test of a mixture containing perfluorooctanesulfonate (PFOS) on fathead minnows (Pimephales promelas), conducted according to OECD Guideline 203, with results indicating the toxicity of the test sample may not accurately reflect that of the PFOS component due to impurities.
|
1995 |
AR226-0905
|
pm97rkn0QMb94DvMb7yVQONq7 |
11 |
|
This document details an acute toxicity test of a mixture containing perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted under OECD guidelines, with specific test conditions and chemical composition noted.
|
1995 |
AR226-0906
|
em03y89RK9Eg1May1Ne53Xw4 |
3 |
|
The document details a Microbios Microtox toxicity test conducted on a mixture containing Perfluorooctanesulfonate (PFOS) to assess its acute toxicity using Photobacterium phosphoreum, with nominal concentrations ranging from 32.5 to 260 mg/L.
|
1995 |
AR226-0907
|
NGJG1xaJVk2zJNEDxM8bB5mzb |
13 |
|
The document details an activated sludge respiration inhibition test conducted on a mixture containing Perfluorooctanesulfonate (PFOS) to assess its toxicity, using activated sludge from the Metro Waste Treatment Plant in St. Paul, MN, and following OECD Guideline 209.
|
1995 |
AR226-0908
|
MMj4edzDNjr5EGR4xd00wrzmL |
10 |
|
The document reports on a failed biodegradation study of Perfluorooctanesulfonate, Lithium salt (PFOS Li salt) conducted by Pace Laboratories for 3M Company, which could not produce usable carbonaceous BOD data after multiple attempts due to potential toxicity issues.
|
1994 |
AR226-0058
|
5LgjMJOjr9dXq5ZNL3nmd4DeV |
4 |
|
The document reports on the evaluation of the mutagenic activity of T-5874 using the Ames Salmonella/microsome test, conducted by NOTOX B.V. in compliance with Good Laboratory Practice standards.
|
1994 |
AR226-0297
|
wKQjem3KmqK6Zpnboj6gEq9m3 |
24 |
|
The document reports on a study conducted by NOTOX evaluating the ability of the substance T-5874 to induce chromosome aberrations in cultured peripheral human lymphocytes, with compliance to Good Laboratory Practice standards.
|
1994 |
AR226-0298
|
bavpYVKXBDxow04M12v1Z4zxg |
27 |
|
The document reports on the evaluation of the mutagenic activity of T-5874, a substance tested in an in vitro mammalian cell gene mutation test using L5178Y mouse lymphoma cells, conducted by NOTOX in compliance with GLP standards.
|
1994 |
AR226-0299
|
oqvBGw2yM9EE5Qn85Lex6dYR |
23 |
|
The document is a final report on the analysis of T-5794 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations and detailing quality assurance inspections.
|
1994 |
AR226-0302
|
GmdqkyMYvb1vbRxRjDdw7KB94 |
37 |
|
The document is a final report on the analysis of T-5878 in a cell proliferation assay conducted on rat liver cells by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations.
|
1994 |
AR226-0303
|
km7bd09Lzke2mgKLpJKRdg77B |
50 |
|
The document reports on a study conducted by NOTOX B.V. evaluating the ability of the substance T-5869, associated with 3M Belgium, to induce chromosome aberrations in cultured peripheral human lymphocytes, adhering to Good Laboratory Practice standards.
|
1994 |
AR226-0318
|
vBn5XQwo1VNQeLjxoYVLbpzQb |
26 |
|
The document details an acute toxicity test of Perfluorooctanesulfonate (PFOS Li salt) on the fish species Pimephales promelas, conducted by Aquatic Biosystems Inc. in 1994, with a focus on determining the LC50 values over a 96-hour exposure period.
|
1994 |
AR226-0111
|
j1O1n8BrEKvD7eoXrDxgxEgp |
9 |
|
The document reports on an acute toxicity test of Perfluorooctanesulfonate (PFOS Li salt) on the aquatic invertebrate Daphnia magna, finding a 48-hour EC50 value of 210 mg/L.
|
1994 |
AR226-0112
|
qaqKYyDY39kNkkjB3Dyw0nEeG |
7 |
|
The document reports the results of a Microtox toxicity test conducted on a mixture of perfluorooctanesulfonate lithium salt (PFOS Li salt) in water, revealing an EC10 value of 564 mg/L and an EC50 value greater than 1000 mg/L for Photobacterium phosphoreum.
|
1994 |
AR226-0113
|
gbxDBwOnkOZJEgpg8YeXnKaVa |
12 |
|
The document details an OECD 209 activated sludge respiration inhibition test conducted on Perfluorooctanesulfonate (PFOS Li salt) to assess its impact on oxygen consumption, noting issues with aeration during the test.
|
1994 |
AR226-0114
|
DvMaE7zaLJ9v0v3bMp15pbXEo |
12 |
|
The document is a final report on a single-dose intravenous pharmacokinetic study of T-5904, a compound sponsored by 3M, conducted by Hazleton Wisconsin, Inc. on rabbits.
|
1994 |
AR226-0979
|
ExEKE5zN2qYBryaVEgQVbM7MR |
24 |
|
The document presents a bioconcentration study of N-methylperfluorooctane sulfonamidoethanol (CAS # 24448-09-7), detailing the method used to determine its n-octanol/water partition coefficient, with results indicating a calculated logP value but lacking confirmation of the substance's purity.
|
1994 |
AR226-1030
|
71g18ypYad5L1a0dVKM7vXeMa |
3 |
|
The document is a final report on the analysis of T-5877 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations and the integrity of the study results.
|
1994 |
AR226-0270
|
oe2EZKvRL7Z7JnpLppQpeE5XD |
53 |
|
The document is a final report on the analysis of T-5877 in a cell proliferation assay conducted on rat liver cells, submitted to 3M Corporation by Hazleton Washington, Inc., confirming compliance with Good Laboratory Practice regulations and the integrity of the study results.
|
1994 |
AR226-0270
|
LgbBKxNQDyOQqmXM5Mqp3n3xQ |
53 |
|
The document reports on a failed biodegradation study of Perfluorooctanesulfonate, Lithium salt (PFOS Li salt), conducted by Pace Laboratories for 3M Company, which could not produce usable carbonaceous BOD data after multiple attempts due to potential toxicity or lack of demand from the sample.
|
1994 |
AR226-0058
|
M23BRMgddR7o5rX77rr9Mzna |
4 |
|
The document details an acute toxicity test conducted on fish (Pimephales promelas) using a test sample of Perfluorooctanesulfonate, Lithium salt (PFOS Li salt) from a 3M production lot, with a focus on determining the LC50 values over a 96-hour exposure period.
|
1994 |
AR226-0111
|
4aw1B0nvDmdEDOaJNkmYODV1R |
9 |
|
The document reports on an acute toxicity study of Perfluorooctanesulfonate (PFOS Li salt) on the aquatic invertebrate Daphnia magna, finding a 48-hour EC50 value of 210 mg/L.
|
1994 |
AR226-0112
|
g2Qdx4NjKqoNpnbLgXoM2g4Z3 |
7 |
|
The document reports the results of a Microtox toxicity test conducted on a mixture of perfluorooctanesulfonate lithium salt (PFOS Li salt) in water, indicating an EC10 value of 564 mg/L and an EC50 value greater than 1000 mg/L for Photobacterium phosphoreum after 15 minutes of exposure.
|
1994 |
AR226-0113
|
aJXdrMgXN0G557NrE41nZvyrN |
12 |
|
The document details an Activated Sludge Respiration Inhibition Test conducted on Perfluorooctanesulfonate, Lithium salt (PFOS Li salt), indicating that the test solutions exhibited low dissolved oxygen levels during the experiment, which may have affected the results.
|
1994 |
AR226-0114
|
VjOaMroed3Jqny9BnyLDOY13w |
12 |
|
This document reports on a biodegradation study of a mixture containing 0.5% perfluorooctanesulfonate (PFOS) conducted by Pace, Inc. for 3M Company, highlighting significant Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD) values while noting the study's lack of methodological clarity and sample purity characterization.
|
1994 |
AR226-0862
|
MEkKnOe22eMJ4B6e3vpovRa9 |
6 |
|
The document reports on an acute toxicity test of a mixture containing 0.5% PFOS, conducted on fathead minnows (Pimephales promelas) using OECD Guideline 203, with results indicating the need for caution due to the presence of impurities in the test sample.
|
1994 |
AR226-0863
|
OzbNJ0g4ypDLon1myMEQME6Nv |
6 |
|
The document reports on an acute toxicity test of a mixture containing 0.5% PFOS (perfluorooctanesulfonate) conducted on Daphnia magna, detailing the test conditions and methodology used in the study.
|
1994 |
AR226-0865
|
KzXQgRMN6KyQap4QoNLwnGxx6 |
4 |
|
The document details a Microtox toxicity test conducted on a mixture containing 0.5% perfluorooctanesulfonate (PFOS) produced by 3M, indicating that the test sample, FC603F, may have incompletely characterized concentrations of impurities affecting the toxicity data.
|
1994 |
AR226-0866
|
1bYxYMO4J72eY41jNbwxMDMK |
13 |
|
The document details an activated sludge respiration inhibition test conducted on a mixture containing 0.5% PFOS, produced by 3M, to evaluate its toxicity using OECD Guideline 209, with results indicating potential inaccuracies due to impurities in the test sample.
|
1994 |
AR226-0867
|
5OdLLoJZXpBQ50wDda8JynVz |
10 |
|
The document reports on the evaluation of the mutagenic activity of T-5874 using the Ames Salmonella/microsome test, conducted by NOTOX B.V. in compliance with GLP standards.
|
1994 |
AR226-0297
|
Lg6zw7e1VqeD1pw2pQRwe5D8w |
24 |
|
The document reports on a study conducted by NOTOX evaluating the ability of the substance T-5874 to induce chromosome aberrations in cultured peripheral human lymphocytes, adhering to Good Laboratory Practice standards.
|
1994 |
AR226-0298
|
jB05LEY5aJye6eap5qeL5wwBy |
27 |
|
The document reports on the evaluation of the mutagenic activity of T-5874 in an in vitro mammalian cell gene mutation test using L5178Y mouse lymphoma cells, conducted by NOTOX in compliance with GLP standards.
|
1994 |
AR226-0299
|
M497bJOOEZ674aKQrvXQmwQDy |
23 |
|
The document is a final report on the analysis of T-5794 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations.
|
1994 |
AR226-0302
|
JKnB4r6bwb618LRmp9wN4Xae |
37 |
|
The document is a final report on the analysis of T-5878 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, with findings compliant with Good Laboratory Practice regulations.
|
1994 |
AR226-0303
|
2jDEEdYDRzJGOJvj7nGo5RxL5 |
50 |
|
The document reports on a study conducted by NOTOX B.V. to evaluate the ability of the substance T-5869, sponsored by 3M Belgium, to induce chromosome aberrations in cultured peripheral human lymphocytes, adhering to Good Laboratory Practice standards.
|
1994 |
AR226-0318
|
8OzzNqVyO2exLrB90BOjDGQrK |
26 |
|
The document reports on a fluorochemical exposure assessment of 3M Decatur chemical and film plant employees, revealing a geometric mean serum PFOS level of 0.944 ppm among chemical plant workers and 0.136 ppm among film plant workers, with the highest PFOS level recorded at 10.600 ppm, and indicates that the findings will inform an updated retrospective cohort mortality study.
|
1994 |
AR226-0950
|
LJNoymdpvkML70m0nNq7ovq2z |
406 |
|
This document reports the results of a study conducted by 3M Company to estimate the log Pow (partition coefficient) for N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol), finding values of 5.6 and 4.4 for different peaks.
|
1994 |
AR226-0379
|
RYxz7dw3x4V28drMZDM22rbk |
17 |
|
The document reports on the physical and chemical properties of the perfluorinated compound 2-(N-Ethylperfluorooctanesulfonamido)ethyl acrylate (also known as D-1), indicating a water solubility of 0.89 mg/L and varying hydrolysis rates at different pH levels, while noting that the purity and identity of the substance
|
1994 |
AR226-0973
|
X8rY0jBgBg5EX37m903nezjOx |
63 |
|
This is a research article discussing the prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats through mevalonic acid supplementation, highlighting significant adverse effects observed at certain dosages of fluvastatin.
|
1994 |
AR226-0559
|
3eBvjeeL1wp2qB3mneoqm7BdJ |
8 |
|
The document reports the results of a study conducted by 3M Company to estimate the log Pow (partition coefficient) for N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), finding values of 5.6 and 4.4 for different peaks.
|
1994 |
AR226-0379
|
5bVvMJ5MGEvwjGJbvLr1ROeGJ |
17 |
|
This letter from DuPont to First Brands discusses the potential risks associated with using Teflon K-20, which contains <0.2% ammonium perfluorooctanoate (APFO), as a dedusting agent in cat litter, highlighting the need to consider the safety of employees, cats, and cat owners.
|
1994 |
AR226-1662
|
3eLXjDG4BaL9gywQJB916bZOE |
3 |
|
The memorandum discusses the interest in incorporating micro powders into shaving gel products, specifically addressing concerns about the elimination rate of C-8 (likely referring to PFOA) from the body and the feasibility of this approach.
|
1994 |
AR226-1663
|
3JwXxvdrpxzjoMBMDLYEzZGZ0 |
2 |
|
This document is a research article discussing the prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats through mevalonic acid supplementation, authored by Roman V. Hrab and colleagues from Sandoz Pharmaceuticals.
|
1994 |
AR226-0559
|
dQgzxZGVm6mdJ69wjj35185q6 |
8 |
|
Unreadable document.
|
1994 |
AR226-1994
|
ZLE5qrB02dmEqL3kwGpr5MY0 |
4 |
|
The Washington Works Industrial Hygiene Report from January 1994 to May 1995 indicates various sampling results for fluorocarbon compounds, specifically noting concentrations of PFOA and PFOS below detection limits in multiple locations, with one instance showing a concentration of 0.02 MPB.
|
1994 |
AR226-2081
|
BRR4dOXNQBvJwBadOxELoba7m |
5 |
|
The memorandum discusses the air quality and emissions of C-8 (likely referring to perfluorooctanoic acid, PFOA) from vent stacks, indicating that the Kinston site's emissions are significantly below community exposure guidelines, thus requiring no additional monitoring or analysis.
|
1994 |
AR226-2147
|
RXG92Vx0OwMQGnEbKbqEXkqX |
2 |
|
The memorandum summarizes a test conducted to evaluate the effects of C-8 concentration, temperature, and gas flow on foaming in a column setup, revealing that foaming increased with higher C-8 concentrations and gas flow, contrary to expectations that higher temperatures would reduce foaming.
|
1994 |
AR226-2435
|
dYjE8mV5avjRZ301xMYvyzk5b |
1 |
|
The document discusses the need for standardized sampling and analysis procedures for C-8 (perfluorooctanoic acid, PFOA) to ensure consistent and comparable results across different sites and years, as current methods vary based on individual preferences.
|
1994 |
AR226-2465
|
o9m38QznxxZoQweNBRwB5NgRD |
4 |
|
The document is a laboratory report by DuPont detailing a static acute toxicity test (LC50) of the substance B-19704 on bluegill sunfish (Lepomis macrochirus), conducted under Good Laboratory Practice compliance, with the study completed on August 26, 1994.
|
1994 |
AR226-2798
|
RjddYoXe80pjNjdy020p0jgYa |
20 |
|
The document reports two cases of acute pulmonary toxicity linked to the inhalation of a new leather protector, Oiled Nubuck Leather Protector, recently introduced in Canada, highlighting the need for emergency physicians to recognize the potential health risks associated with such products.
|
1994 |
AR226-3708
|
3LdpxbY6EjpVYJD7beOKk4Ba |
3 |
|
The document is a laboratory report from Haskell Laboratory, authored by John V. Sarver, indicating that the substance H-203M, produced by E. I. du Pont de Nemours and Company, was found to be a slight skin irritant in an acute irritation study conducted on rabbits.
|
1994 |
AR226-3001
|
B5j5NQRw4bLbe7MZqG04N3kvL |
8 |
|
The document reports on a 100-person human patch test conducted by Biosearch, Inc. for E. I. du Pont de Nemours and Company, which found that both the control item (H-20385) and the test item (H-20386) did not produce adverse skin responses, indicating no potential for delayed contact hypersensitivity.
|
1994 |
AR226-3000
|
Z8RwMOM6BGmMj6KpE63xXEaX7 |
25 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-20431, which resulted in severe erythema and moderate edema in rabbits, indicating significant skin irritation potential.
|
1994 |
AR226-3002
|
yrMYRBwxmJ27rQyjmxQ3Om7p3 |
9 |
|
The document reports a study conducted by DuPont to determine the approximate lethal dose (ALD) of the substance H-20431 in male rats, finding that the ALD is greater than 11,000 mg/kg, indicating very low toxicity.
|
1994 |
AR226-3003
|
YrGkY4m84eEvp7z3bmD9DMVZV |
7 |
|
The document is a report by DuPont detailing a study on the acute toxicity of the test substance H-19518, a perfluorinated compound, conducted in accordance with OECD guidelines.
|
1994 |
AR226-3005
|
YDn8z9a9QMQ1wnL2keyD140zy |
15 |
|
The document is a subchronic inhalation toxicity study report conducted by E. I. du Pont de Nemours and Company on a test substance, likely related to PFOA or PFOS, which was completed on December 21, 1994, and noted a deviation in compliance with Good Laboratory Practice standards regarding the characterization of the test substance.
|
1994 |
AR226-3007
|
aXawoYpXvpG1Jqyo1d4J9aER |
157 |
|
The document discusses the review of pancreatic lesions in high-dose male subjects from a two-year study on FC143 (C8) conducted by 3M, noting similar incidences of acinar cell adenomas/carcinomas between the 3M and Haskell studies, while highlighting a significantly higher incidence of acinar cell hyperplasia in the Haskell study.
|
1994 |
AR226-3371
|
MJVkMnxEvxqLw6QGLpnqvy9y |
2 |
|
The document reports on a biodegradation test of a mixture containing 0.5% perfluorooctanesulfonate (PFOS) conducted by Pace, Inc. for 3M Company, revealing high Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD) values, but lacking detailed methodology and sample characterization.
|
1994 |
AR226-0862
|
Ozx7GoNqQVGZq33JbV9M3rj5M |
6 |
|
The document details an acute toxicity test conducted on fathead minnows (Pimephales promelas) using a mixture containing 0.5% perfluorooctanesulfonate (PFOS) and other components, following OECD Guideline 203, with results indicating potential toxicity that may not accurately reflect the fluorochemical's effects due to impurities.
|
1994 |
AR226-0863
|
Kzyv34YKo51z6Qdn2amErQ622 |
6 |
|
The document details an acute toxicity study of a mixture containing 0.5% perfluorooctanesulfonate (PFOS) on Daphnia magna, conducted under OECD Guideline 202, with findings indicating that the data may not accurately reflect the toxicity of the fluorochemical component due to incompletely characterized impurities.
|
1994 |
AR226-0865
|
Z43kDw6XeZN78r9wekD0mkYNL |
4 |
|
The document details a Microtox toxicity test conducted on a mixture containing 0.5% perfluorooctanesulfonate (PFOS) produced by 3M, indicating that the data may not accurately reflect the toxicity of the fluorochemical component due to incompletely characterized impurities.
|
1994 |
AR226-0866
|
VK36pxJbv2dN5mBG8d5EGpkdp |
13 |
|
The document describes an activated sludge respiration inhibition test conducted on a mixture containing perfluorooctanesulfonate (PFOS) produced by 3M, indicating that the test sample is FC603F, which consists of 0.5% PFOS among other components, and outlines the testing methodology and conditions used for assessing its toxicity.
|
1994 |
AR226-0867
|
ZB3qvRRGk9gbkdnpJna4XMqbZ |
10 |
|
The document outlines a research protocol by 3M to analyze inpatient and outpatient claims data from Decatur chemical and film plant employees between 1993 and 1998, focusing on the health impacts potentially related to exposure to perfluorinated compounds.
|
1993 |
AR226-0022
|
Np7awd6K6oE2LGbN0956kBR8 |
19 |
|
The document is a final report on a genotoxicity test of T-5711.1 conducted by Hazleton Washington, Inc. for 3M Corporation, which assessed unscheduled DNA synthesis and cell proliferation in rat liver cells, ensuring compliance with Good Laboratory Practice regulations.
|
1993 |
AR226-0295
|
jBMdO22ZQmMGbXa9pY0KkgnQ2 |
46 |
|
The document is a final report of a mutagenicity test on T-5711 conducted by Hazleton Washington, Inc. for 3M Corporation, using an in vivo rat micronucleus assay to comply with U.S. EPA FIFRA guidelines.
|
1993 |
AR226-0296
|
DGoeebpOaXY9Q7KLZvX98O32M |
41 |
|
This document outlines a method developed by 3M for the determination of N-Ethyl Perfluorooctanesulfonamide in air using silica gel sampling tubes and gas chromatography.
|
1993 |
AR226-0241
|
QJeyekQwjgoXbDxJ6LxJpZon7 |
2 |
|
The document is a final report on a mutagenicity test of T-5710 conducted by Hazleton Washington, Inc. for 3M Corporation, using an in vivo rat micronucleus assay to comply with U.S. EPA FIFRA guidelines.
|
1993 |
AR226-0250
|
LJkE0pKDYowJxLyk6qO38eJm3 |
26 |
|
The document is a final report on a genotoxicity test of T-5710.1, conducted by Hazleton Washington, Inc. for 3M Corporation, which evaluated unscheduled DNA synthesis and cell proliferation in rat liver cells, adhering to Good Laboratory Practice regulations.
|
1993 |
AR226-0251
|
OJy5RepLV66q5y8meD6L1eKLK |
32 |
|
The document discusses a vapor pressure test of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) and its mixture with PFOS, highlighting methodological concerns and the analysis of fluorochemical content before and after air bubbling through various stock solutions.
|
1993 |
AR226-1030
|
x5mRdarmOJOpKorMe9L4RbED0 |
4 |
|
The document details a vapor pressure study of perfluorooctanesulfonate (PFOS) conducted by 3M, highlighting methodological concerns and presenting results from analyzing the fluorochemical content before and after air bubbling through various stock solutions.
|
1993 |
AR226-1030
|
jgLYJoGx7YL60a9w5gmDV6anR |
4 |
|
This document outlines a method developed by 3M for the determination of N-Ethyl Perfluorooctanesulfonamide in air using silica gel sampling tubes and gas chromatography.
|
1993 |
AR226-0241
|
4v0EOp706b1MwJZdVzrNJe3Ra |
2 |
|
The document is a final report on a mutagenicity test for T-5710 conducted in an in vivo rat micronucleus assay, submitted to 3M Corporation by Hazleton Washington, Inc., indicating compliance with EPA FIFRA Good Laboratory Practice Standards.
|
1993 |
AR226-0250
|
44rVzK37VeGV037B6MYG5n7gG |
26 |
|
The document is a final report on a genotoxicity test of T-5710.1, conducted by Hazleton Washington, Inc. for 3M Corporation, which assessed unscheduled DNA synthesis and cell proliferation in rat liver cells, ensuring compliance with Good Laboratory Practice regulations.
|
1993 |
AR226-0251
|
Vjre9oGL853k0RzkEOaNdKGZN |
32 |
|
The document outlines a research protocol by 3M to analyze inpatient and outpatient claims data from Decatur chemical and film plant employees between 1993 and 1998, aiming to compare observed claims events to expected numbers while accounting for age and gender, with a focus on the potential health impacts of exposure to perfluorinated compounds.
|
1993 |
AR226-0022
|
om8ZzDKbZymZ6ZkZgOv1n0oY8 |
19 |
|
The document presents a biodegradation study of a mixture containing perfluorooctanesulfonate (PFOS) produced by 3M, indicating that while the majority of the product components are readily biodegradable, no reliable conclusions can be drawn due to insufficient characterization of the sample and methodology.
|
1993 |
AR226-0701
|
6bdw5yKJ8beJOxnY5zbkVJbEg |
13 |
|
The document reports on a microbial inhibition test evaluating the dehydrogenase activity of a mixture containing 3.0% PFOS (perfluorooctanesulfonate) produced by 3M Company, indicating that the test results are inconclusive due to incomplete characterization of the sample and lack of detailed methodology.
|
1993 |
AR226-0705
|
evEJmK0NVrgjg4dwV7N46maXe |
14 |
|
The document reports on an acute toxicity test conducted on fish using a mixture containing 3.0% PFOS (perfluorooctanesulfonate) as part of the test substance FC-201F, with a 48-hour no observed effect concentration (NOEC) determined to be 500 ppm.
|
1993 |
AR226-0706
|
evNyYGGgm17NExwYb7zVNweBp |
14 |
|
The document reports on a toxicity test of a mixture containing 1.30% PFOS, conducted on the aquatic plant species Scenedesmus subspicatus, revealing a 72-hour EC50 value of 65 mL/L based on nominal concentrations.
|
1993 |
AR226-0850
|
gDEb7BN33joRBN2oxbNbRjqba |
10 |
|
The document is a final report on a mutagenicity test of T-5711 conducted by Hazleton Washington, Inc. for 3M Corporation, using an in vivo rat micronucleus assay to comply with U.S. EPA FIFRA guidelines.
|
1993 |
AR226-0296
|
EmqLyBd46N6N7rRmb5r9OYV1L |
41 |
|
The document is a final report on a genotoxicity test of T-5711.1 conducted by Hazleton Washington, Inc. for 3M Corporation, which involved in vivo/in vitro assays in rat liver cells to assess DNA synthesis and cell proliferation.
|
1993 |
AR226-0295
|
8VOyXR5VBgdzd6vexJx0oGDLm |
46 |
|
The document details a manometric respirometry test conducted in 1993 to assess the biodegradability of a mixture containing 6% PFOS, indicating that the data may not accurately reflect the biodegradability of the fluorochemical component due to incompletely characterized concentrations of impurities.
|
1993 |
AR226-0899
|
nmg59Qd99z54bbJoro5VXMY6G |
10 |