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1990s

Documents dated 1990–1999.

Page 2 of 11 — 1,012 documents
Title / Summary Year AR226 Docket Hash ID Pages
The document is a letter from the EPA to Dr. William A. Weppner of 3M discussing the development of a product stewardship Memorandum of Understanding regarding perfluorooctane sulfonyl fluoride, indicating that further review of health effects and exposure assessments is needed before determining the appropriateness of such an agreement. 1999 AR226-0640 ByxXqgrDwbeJXqMQR5839ayKk 20
The document discusses an expert review of mouse lymphoma cell mutation testing on 3M product T-6906, indicating that the study was deemed technically inadequate and insufficient to draw valid conclusions regarding its mutagenic activity, necessitating a repeat of the study under acceptable test conditions. 1999 AR226-0254 M4axXgoqgNnwERqVOVK6jZ14x 3
This is a final field report prepared by Battelle for a multi-city study analyzing trace-level FC residuals in Mobile, Alabama, and Pensacola, Florida, under Project Number N100672-01. 1999 AR226-0677 MJwd6458pD3OMz2zN1q6YjmqM 17
This is a field report from Battelle regarding a multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on trace-level analysis of specific FC residuals and human exposure assessment. 1999 AR226-0678 qkd6no7BvNq6eBbgX4MVLjN1K 16
This is a final field report from Battelle (Project Number N100672-01) detailing the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, focusing on the sampling of FOSE-based fluorochemical residuals for environmental and human exposure assessment. 1999 AR226-0679 M44OampNdLq439N4N3MR92qKy 16
This report evaluates the statistical quality of 12 data sources on serum PFOS levels in non-occupational human populations, revealing a geometric mean PFOS blood level of 28.2 ppb, with only pooled serum from U.S. blood banks deemed defensible for analysis. 1999 AR226-0036 jmd6p7J0pm0ypeYX5Nezb886Q 10
The document reports the vapor pressure of perfluorooctanesulfonate (PFOS), produced by 3M Company, as 3.31 x 10^-4 Pa at 20°C, determined using the Spinning Rotor Gauge method, with a purity of 90.49%. 1999 AR226-0047 Rp5x3jk7MJ5xzQgDJkZn6x1kk 2
The document reports on a study conducted by Wildlife International, Ltd. for 3M Company to determine the n-octanol/water partition coefficient of perfluorooctanesulfonate (PFOS), which was ultimately deemed infeasible due to the formation of an emulsion during testing. 1999 AR226-0050 pBryL6NdrbRKk35wa7yNKJpZa 3
The document reports on a study conducted by Wildlife International Ltd. to determine the vapor pressure of PFOS using the spinning rotor gauge method, sponsored by 3M Corporation, and completed on May 5, 1999, while noting some deviations from Good Laboratory Practice Standards. 1999 AR226-0048 E1z2ZxnVgY6rGX7QbdvkogMx 26
The document details a method developed by Dr. Richard Purdy of 3M and Don Mackay for determining the air/water partition coefficient of perfluorooctanesulfonate (PFOS), although it notes that there is no standardized methodology for regulatory purposes. 1999 AR226-0051 9Jg071dyJwz9GgjQJJ3B5ZMbe 10
This document reports on a study conducted by Wildlife International Ltd. to determine the water solubility of PFOS using the shake flask method, sponsored by 3M Corporation, and outlines compliance with Good Laboratory Practice standards. 1999 AR226-0052 3JE4E6D1521gL6X7173Qv866J 35
The document reports on a water solubility test for Perfluorooctanesulfonate (PFOS) conducted by 3M, finding an overall mean solubility concentration of 519 mg/L in NANOpure water at 20°C. 1999 AR226-0054 2jmXq1EzM0VvdNgxGD9L8V0w7 22
The document presents a fugacity modeling study of perfluorooctanesulfonate (PFOS), conducted by Don Mackay, indicating that PFOS tends to remain in water when released, with slow degradation and significant persistence in the environment. 1999 AR226-0060 jmR4k62658X3Z7M3gK6M6bvEZ 4
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using standard EPA methodology and a conservative uncertainty factor. 1999 AR226-0071 MKd1Jzq9qR1wkmbYjZkkEXx9 6
This is a field report from Battelle detailing the multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on the collection of samples for trace-level analysis of specific FC residuals. 1999 AR226-0073 rB6MaL9RRL0RNra0aavyrNwEV 16
The document outlines a review of field sampling procedures conducted by Battelle during a city survey in Columbus, Georgia, as part of the Multi-City Human Exposure Assessment Study, focusing on the appropriateness of sampling techniques for fluorochemicals, including PFOA and PFOS, in various environmental sources. 1999 AR226-0072 pmYnYb2dGaO9kebYnNMrEw4wd 22
This is a final field report from Battelle for the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, under Project Number N100672-01, focusing on the analysis of FOSE-based fluorochemical residuals. 1999 AR226-0074 jBQy0R59ggMr09d9q2VBqJoz9 16
The document is a final field report detailing the multi-city study conducted by Battelle in Mobile, Alabama, and Pensacola, Florida, focusing on the sampling and analysis of perfluorinated compounds, including PFOA and PFOS, as part of Project Number N100672-01. 1999 AR226-0075 0gQ1NEp1k3RND7vXrngV9Qd1b 17
This document is an amendment to the Quality Assurance Project Plan for the Empirical Human Exposure Assessment Multi-City Study, detailing changes to sampling protocols, including the addition of labeling for 'Trip Blank' samples. 1999 AR226-0077 3ek21mqNggyX9ngp17rZow3DD 23
This document details an acute toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the fish species Pimephales promelas, using a sample from 3M with a purity of 90.49%, following OECD and OPPTS guidelines, to determine LC50 values over a 96-hour exposure period. 1999 AR226-0082 6bDmn3OKRjvDB2bEQBeEayL5R 4
The document reports on a toxicity study of perfluorooctanesulfonate (PFOS) conducted by 3M, which assessed its effects on the aquatic plant species Selenastrum capricornutum, finding a purity of 90.49% and detailing the testing methodology and conditions. 1999 AR226-0084 8R9o55LmoQRNedORdnQnLr6Da 6
The document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted under OECD guidelines, with a purity of 90.49% and results indicating the EC50 values calculated for the test. 1999 AR226-0086 0x6dpQdwZLKnB4rXNxyxwBd 4
The document details a study on the acute toxicity of perfluorooctanesulfonate (PFOS) sourced from 3M, assessing its impact on shell growth in the eastern oyster (Crassostrea virginica) over a 96-hour exposure period, with a purity of 90.49% confirmed through various analytical techniques. 1999 AR226-0088 KJdNr46ybR8BxM9mrZgXVNg76 4
This document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the freshwater mussel species Unio complanatus, conducted under EPA guidelines, with a test substance purity of 90.49% and results analyzed for LC50 values. 1999 AR226-0090 Znqn3oOqjZVeJe6L8E59VGDxd 4
The document details an OECD 209 activated sludge respiration inhibition test conducted on perfluorooctanesulfonate (PFOS) sourced from 3M, with a purity of 90.49%, to assess its impact on dissolved oxygen concentrations in wastewater treatment conditions. 1999 AR226-0092 3JORLdwBNoyY6OQLaY7jjm3Kn 3
This document is an amended final report on a 96-hour shell deposition test conducted by Wildlife International Ltd. for 3M Corporation, evaluating the ecological effects of PFOS on the Eastern oyster (Crassostrea virginica), completed on August 11, 1999, and amended on April 26, 2000. 1999 AR226-0089 ybkZbLmR7eaX0RVXXL5xXo5Y6 56
This document is an amended final report of a 96-hour static acute toxicity test conducted by Wildlife International Ltd. on PFOS using the freshwater mussel (Unio complamatus), sponsored by 3M Corporation, and it outlines compliance with Good Laboratory Practice standards. 1999 AR226-0091 jjX1RQgXJMQKx9vyY54eb13O 59
The document details an acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, to determine the LC50 values over a 96-hour exposure period. 1999 AR226-0094 1g9wQnObboZLGMV06dnjRNqrj 4
The document details a chronic toxicity study of perfluorooctanesulfonate (PFOS) conducted on early life stages of fish (Pimephales promelas) using a 47-day flow-through method, with a purity of 90.49% and statistical analyses to assess significant differences from control groups. 1999 AR226-0096 dQdzp9pzbVeVGKpLaoEODvV7b 5
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) on the freshwater invertebrate Daphnia magna, conducted by Wildlife International, Ltd., which assessed survival, reproduction, and growth over a 21-day exposure period, with a purity of the test substance determined to be 90.49%. 1999 AR226-0098 rwE496GLxrJbGzjv12NKv1mG 6
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, and outlines the methods and statistical analyses used to evaluate the effects of PFOS over a 35-day exposure period. 1999 AR226-0100 85Q77BKnmKJVE1yKwRp8vYdb5 7
The document is a final report on an early life-stage toxicity test of PFOS conducted with the fathead minnow (Pimephales promelas) by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and compliant with Good Laboratory Practice standards. 1999 AR226-0097 EdZDD8Q08aGQXqaBNad4LNqZn 88
This document details a dietary acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on northern bobwhite quail, using a sample from 3M with a purity of 90.49%, to assess its effects under controlled conditions. 1999 AR226-0104 zzrp85E4mY1k1rDppzeXN0NE6 9
The document is a final report on a semi-static life-cycle toxicity test of PFOS conducted with the cladoceran Daphnia magna, submitted by Wildlife International Ltd. to 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization and stability determination. 1999 AR226-0099 jgLRBkm3eL0KXDBZdypQ26BD5 93
The document is a final report on a flow-through life-cycle toxicity test of PFOS conducted with the saltwater mysid (Mysidopsis bahia) by Wildlife International, Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization. 1999 AR226-0101 V33Rry7KExX2pgrbMOgnwGMQg 76
The document details a dietary LC50 study on PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and adheres to Good Laboratory Practice standards, although the test substance characterization did not fully comply with GLP. 1999 AR226-0103 X8an4DmMQnZoJboaqbD9O4ZB4 89
The document is a final report by Covance Laboratories on a study investigating chromosomal aberrations in human whole blood lymphocytes exposed to PFOS, submitted to 3M Corporate Toxicology, and conducted in compliance with EPA regulations. 1999 AR226-0131 R2j5NYemr8raaa0v0YxB45rLV 41
This document is a second draft cell proliferation report detailing a 104-week dietary chronic toxicity and carcinogenicity study of perfluorooctane sulfonic acid potassium salt (PFOS) in rats, prepared by Pathology Associates International for 3M. 1999 AR226-0142 LJR782eygN68dg86Vdy3LnqqQ 26
The document details a pathology review of a PFOS six-month toxicity study in monkeys, concluding that the deaths of two high-dose male monkeys were likely related to compound toxicity, with one showing signs of acute pneumonia and the other exhibiting liver changes indicative of toxicity. 1999 AR226-0150 066nDbpVNyj2pkmd0L9YeLjEV 2
The document is a pathology report detailing the findings from a 26-week toxicity study of perfluorooctane sulfonic acid (PFOS) in cynomolgus monkeys, which revealed hepatocellular vacuolation and hypertrophy, along with increased lipid droplets and glycogen in liver cells. 1999 AR226-0149 dDYmGnDnQExo7YLGpbe7Gb5rq 60
The document discusses a study by Kendall B. Wallace, Ph.D., investigating the inhibitory effects of selected perfluorochemicals, including PFOA and PFOS, on mitochondrial fatty acid oxidation using rat liver mitochondria. 1999 AR226-0170 q3mOea9jzdwNkg7RvK58jNjVn 4
This document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M Specialty Chemicals Division, to assess its oral absorption, clearance, and metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes. 1999 AR226-0180 aDxY64G8JgOjjJ72VgDzgwLJ9 6
The document reports on a developmental toxicity study of N-EtFOSE (N-Ethyl-Perfluoroocyanesulfonamido Ethanol) in pregnant rabbits, finding that while there were dose-related effects on body weight and food consumption at higher doses, the compound was not teratogenic, with no malformations observed in the fetuses. 1999 AR226-0274 NEjaz5k3X2LGwj6pbMkeNDBQR 1
The document outlines a protocol for a study on N-EtFOSE bile method development in rats, conducted by 3M's Corporate Toxicology department, to support an ongoing ADME study in Cynomolgus monkeys. 1999 AR226-0288 e1MLVwd7QOrqgV1j6VoeoDpbE 7
The document outlines a study protocol by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluorooctanesulfonamide (PFOSA 1999 AR226-0290 4nXb791wJB75kD6n6oE4OLKG 14
The document discusses concerns regarding the finalization of a toxicity study report on N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) conducted by Covance Laboratories, specifically questioning the conclusion of a no observable adverse effect level (NOAEL) of less than 3 ppm based on body weight gain data in rats. 1999 AR226-0301 Qg5b60L9OQmqb6w4q1vqwJdGL 1
This is a Quality Assurance Project Plan for the Multi-City Study Sampling Task (N10Q666) prepared by Battelle, effective May 14, 1999, detailing project management, quality assurance objectives, and sampling methodologies. 1999 AR226-0952 6BmzJyy2Z9844pegr01kOMkk6 52
The document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA 1999 AR226-0332 bKmgwba41n09NORzqnZrYae3 14
This document reports on a dietary LC50 study of PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and indicates that the study was performed in compliance with Good Laboratory Practice standards, although some aspects of substance characterization did not fully adhere to GLP compliance. 1999 AR226-0953 jjbnBv6aJmg8qbEewGg4RX9 83
The document reports on a developmental toxicity study of PFOS (Perfluorooctanesulfonate) conducted on pregnant rabbits, indicating that while there were dose-related effects on body weight and food consumption at higher doses, no teratogenic malformations were observed. 1999 AR226-0949 VGOO9mVxV6wMb1e5gGrLYEg0N 295
The document reports the melting point determination of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), indicating a melting point range of 55°C to 60°C, suggesting the presence of impurities in the sample. 1999 AR226-0347 B5Xqyvbx438zXKaXRwdpgEyQ4 3
The document is a laboratory report from 3M Environmental Technology and Services detailing pilot data on perfluorooctanesulfonate (PFOS) concentrations in a limited number of pediatric serum samples, indicating that while concentrations were above detection limits, no conclusions can be drawn due to the small sample size, with plans for a larger study involving over 600 samples. 1999 AR226-0961 v1oMdLBnb1L3X5L0vgVxM8d2Y 66
The document reports on a stability study of N-methylperfluorooctanesulfonamido-ethyl acrylate (MeFOSEA), revealing that its hydrolysis half-lives vary with pH and temperature, with longer half-lives observed at lower temperatures and higher pH levels. 1999 AR226-0380 VZM6N2NY5gYL2VJdmXOMzqzZ 70
The document is a final report on a developmental toxicity study of N-EtFOSE conducted in rabbits, detailing methods, results, and conclusions regarding the substance's effects. 1999 AR226-0967 4aqB4wKZeo1pOdDnB46LEkv4j 318
3M submitted a TSCA Section 8(e) supplemental notice to the EPA detailing refined analyses of human sera samples that confirmed the presence of perfluorooctane sulfonate (PFOS) and detected additional perfluorinated sulfonates (PFS) and perfluorinated carboxylic acids (PFCAs). 1999 AR226-0540 a1aVBxoZB3qg6KkgKoQy4XmLX 3
The document reports on a cross-fostering study of PFOS (perfluorooctanesulfonate) conducted by 3M, detailing the study's methodology, findings related to toxicity, and the purity of the PFOS used, with results analyzed between July 1999 and February 2000. 1999 AR226-0556 d2pEO1MZ3yZaZnoQmgw9erDb 9
This is a final report for Protocol 418-009 detailing a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of N-EtFOSE in rats, with the sponsor's study number 6316.5, dated June 30, 1999. 1999 AR226-0552 3ejo0jpvgZaoDXMM8d1ewOmYD 243
The Tennant Farm Herd Health Investigation report, prepared by the EPA/DuPont Cattle Team, evaluates the health of cattle on the farm, identifying issues such as malnutrition and toxicology concerns, but does not specifically mention PFOA or PFOS. 1999 AR226-1243 3QLmJm4yR82NZZ2ZnkxG3dBQJ 121
This document is an amended report of a dietary LC50 study on PFOS conducted with mallards by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions noted regarding substance characterization and stability analysis. 1999 AR226-1735 9bKr7KMmJrmRmXVmvaqGKy35 72
This document reports on a dietary LC50 study of PFOS conducted on the Northern Bobwhite by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions regarding the characterization of the test substance. 1999 AR226-1747 0Lz49r41qpxq2wDKJojr5Lpvm 69
The document reports on a study of the hydrolysis stability of N-methylperfluorooctanesulfonamido-ethyl acrylate (MeFOSEA), revealing that its degradation half-lives vary with pH and temperature, with longer half-lives observed at lower temperatures and higher pH levels. 1999 AR226-0380 85vLZzww4bYer4gbxoMKyO54Z 70
This document reports on a dietary LC50 study of PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and amended on March 23, 2004, noting compliance with Good Laboratory Practice standards despite some exceptions regarding test substance characterization. 1999 AR226-1781 gbY3vO3wKMok0399mKg7B1YVV 72
This document reports on a dietary LC50 study of PFOS conducted on the Northern Bobwhite by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards, although the test substance was not fully characterized at the time of testing. 1999 AR226-1825 vB4j4YzLQz3QYNp3qVzpR8ZeZ 69
This document details a dietary LC50 study on PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and amended on March 23, 2004, in compliance with Good Laboratory Practice Standards. 1999 AR226-1828 Ymojn4qX4adabqgQB2xyjbek 73
This document details a dietary LC50 study of PFOS conducted on the Northern Bobwhite by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards and noting that the test substance was recharacterized post-study. 1999 AR226-1781 kyOxnGRJvnB7o9wDEN7av8G0 69
3M submitted a TSCA Section 8(e) supplemental notice to the EPA detailing refined analyses of human sera samples that confirmed the presence of perfluorooctane sulfonate (PFOS) and detected additional perfluorinated sulfonates (PFSs) and perfluorinated carboxylic acids (PFCAs). 1999 AR226-0540 nmbBz1YGRx8VE9m9nLzQokBbz 3
The document is a correspondence from Larry R. Zobel of 3M to the EPA, summarizing findings from rat teratology studies on 3M fluorochemicals, specifically noting that a mixture of perfluoroethanol derivatives caused significant fetal malformations, including cleft palates and skeletal abnormalities. 1999 AR226-0542 krZdQZrRVpywKBjNJBE8R8Z0 5
3M submitted a supplemental notice to the EPA detailing recent studies on the detection of perfluorooctanesulfonate (PFOS) in tissue samples from various animal species, highlighting initial screening data on PFOS distribution in biota using high-performance liquid chromatography-tandem mass spectrometry. 1999 AR226-0541 mbmE5QgXNkyGM9XannMam37oO 4
3M is sending the EPA two papers on perfluorooctane sulfonate (PFOS) and organic fluorochemistry, along with a note about a forthcoming preliminary exposure assessment, to facilitate a discussion on these topics. 1999 AR226-0546 mpE1019KLOzMV426kvOn6aR2g 1
3M submitted an overview paper to the EPA detailing the manufacture, use, distribution, and environmental release of sulfonyl-based fluorochemicals, including PFOS, along with a preliminary life-cycle assessment of exposure pathways and ongoing stewardship initiatives. 1999 AR226-0549 zzrwkye1pjjBzwV9VLQm7wrrn 2
The document discusses the science of organic fluorochemistry, detailing 3M Company's history and experience in synthesizing organofluorine molecules using the Simons Electro-Chemical Fluorination process, which replaces hydrogen atoms in organic feedstocks with fluorine. 1999 AR226-0547 Yr5nxO96V88RxnV1wNx9e1NGk 12
The document reports on a cross-fostering study of PFOS (perfluorooctanesulfonate) conducted by 3M, detailing the study's methodology, findings, and analysis conducted between 1998 and 2000, with a focus on the effects of PFOS on rat development. 1999 AR226-0556 K6XaOy9n17oyN2LnropM4NYzX 9
3M's January 21, 1999 document summarizes the biological effects, health risks, and future research plans related to perfluorooctane sulfonate (PFOS), noting its presence in human serum samples at levels of tens of parts per billion. 1999 AR226-0548 446yGoD8BmJzBwd0D9Rq7Ng4Q 135
This is a final report for Protocol 418-009 detailing a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of N-EtFOSE in rats, with the sponsor's study number 6316.5 and a report date of June 30, 1999. 1999 AR226-0552 vV56RrRwZYRJB93mJrbe47gkw 243
The document details a dietary LC50 study on PFOS conducted by Wildlife International Ltd. for 3M Corporation, which was completed on April 26, 2000, and amended on March 23, 2004, while noting compliance with Good Laboratory Practice standards. 1999 AR226-1849 km8rE3y4bwkVLdo2xn075QQYb 69
The document reports on a dietary LC50 study of PFOS conducted on mallards by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards, with an amended report date of March 23, 2004. 1999 AR226-1852 5b1ypE6QbMy4zNyJNvd5kO9L8 72
This document is a report prepared by 3M Company on May 26, 1999, providing an overview of the use, distribution, and environmental release of sulfonyl-based fluorochemicals, intended to inform exposure assessment and product stewardship initiatives. 1999 AR226-0550 Z4yEEd03Ybwm1OND67eKJVQeJ 350
This document outlines a protocol for a pharmacokinetic recovery study of potassium perfluorooctane sulfonate (PFOS) in rats, conducted by 3M Environmental Technology and Safety Services, aimed at determining PFOS levels in liver and serum specimens. 1999 AR226-0566 3JbeL9nyQD7M0da8rVwGwVzj3 25
This document outlines the protocol for a pharmacokinetic study of potassium perfluorooctane sulfonate (PFOS) in rats, sponsored by 3M, aimed at determining PFOS levels in liver and serum specimens. 1999 AR226-0567 M422NndanGZpMEBkOX3NeOxvx 24
The document is a final report detailing a pharmacokinetic study of PFOS conducted in rats, sponsored under study number T-6295.12, which includes methods, results, and conclusions regarding the absorption and distribution of PFOS in the test subjects. 1999 AR226-0565 2Nj66eMB2RVLLz26LbOaXVmq7 172
The document summarizes a two-generation reproduction study on PFOS (Perfluorooctanesulfonate) conducted on rats, detailing the dosing procedures, study design, and indicating that no deaths occurred in the parental generation (Fo) animals. 1999 AR226-0569 Mk6dXR0r47Z7EX9o7BrdDYb7 11
This document is the final report of a pharmacokinetic recovery study of PFOS conducted in rats, detailing the study's methods, results, and conclusions, with a focus on the absorption and elimination of PFOS in the test subjects. 1999 AR226-0568 rpmwKraoqvjrZgNw0qg88nmd7 160
The document is an analytical laboratory report detailing the determination of the presence and concentration of Perfluorooctanesulfonate (PFOS) in the serum of Sprague-Dawley rats that were exposed to potassium perfluorooctanesulfonate via gavage, conducted by 3M Environmental Laboratory. 1999 AR226-0570 8oOmLjkv0xop864w46Kgw8J5 113
This document is a final report on a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of PFOS conducted in rats, detailing the study's methods, results, and conclusions. 1999 AR226-0563 mrL6eXd48XZ6oDLoqmpm2KdB 645
The document is a pathology report detailing an ancillary study on the pharmacokinetics of PFOS in CRL:CDBR VAF/Plus rats, indicating that no significant ultrastructural differences were found in the liver and lung tissues between treated and control groups. 1999 AR226-0572 8qBzpVeEQ5e1Dwdn5m78VrEo 74
This document is the final report of a cross-fostering study on PFOS conducted in rats, detailing the study's methods, results, and conclusions, with the sponsor's study number T-6295.13 and a final report date of July 23, 1999. 1999 AR226-0571 9JZjpaOeLjxoG4MajegrEVDRq 257
The document compares the determination of C-8 (a perfluorinated compound) levels in air using Tenax Tube and Aqueous-impinger methods across various locations in a facility, finding a statistically significant increase in C-8 levels only in FEP Clean Rooms while other locations showed equivalent results. 1999 AR226-1999 zbRmzek4p9j6JRR9x5xxxR26g 1
The document is a letter from the EPA to Dr. William A. Weppner of 3M, discussing the development of a product stewardship Memorandum of Understanding (MOU) regarding perfluorooctane sulfonyl fluoride and indicating the need for further review of health effects and exposure assessments before concluding on the appropriateness of such an agreement. 1999 AR226-0640 X4QrM323Yjn0M6NZYrdZO69K 20
The document reports the analysis of water samples for FC-143 (a perfluorinated compound) collected by Nemours & Co., with a detected concentration of 0.029 µg/L and a noted detection limit of 0.052 µg/L. 1999 AR226-2464 gdmD22RGJe7aLjkZpkLg4vbN 1
Environment Canada is initiating consultations on proposed actions to address perfluorocarboxylic acids (PFCAs) and their precursors due to concerns about their persistence, bioaccumulation potential, and increasing concentrations observed in Arctic mammals. 1999 AR226-3593 gjQgkVzLXBkgbO80MBdvEqmQ 4
Environment Canada and Health Canada assessed four fluorotelomer-based substances, determining they degrade into long-chain perfluorinated carboxylic acids (PFCAs) that are persistent and potentially harmful, leading to the issuance of ministerial prohibitions on their importation or manufacture under CEPA 1999. 1999 AR226-3596 KGK24k7jkJ1jnrnnxKYYZpRyN 10
The document outlines the Canadian Environmental Protection Act (CEPA) 1999's framework for assessing and managing persistent and bioaccumulative toxic substances, including perfluorinated compounds (PFCs), emphasizing the need for risk assessments by Environment Canada and Health Canada to evaluate their potential dangers to human health and the environment. 1999 AR226-3600 MJMn9RV032mKq098595YLqEGV 11
The document is a meeting notice regarding a strategy session for the Washington Works RFI Team to review preliminary risk assessment results related to C-8 (PFOA) and to develop a risk-based cleanup level, emphasizing the need for business buy-in before submitting findings to the EPA. 1999 AR226-2547 zQR00bJGmBDdpk6Z6zL0Eodgg 1
The document outlines the results of a RCRA Facility Investigation at the DuPont Washington Works site, emphasizing the site's characterization and monitoring efforts related to environmental protection, particularly concerning perfluorinated compounds like PFOA and PFOS. 1999 AR226-2550 6BEb8pkEvZX4VJ8kDQVX105Ed 33
The document is a cover letter from DuPont Washington Works submitting a RCRA Facility Investigation Report regarding findings related to hazardous waste management, including potential contamination from perfluorinated compounds, to the U.S. EPA for review and comment. 1999 AR226-2548 q3Bq4GBpkbqj9Q9DXMJOZnY1n 150
The document discusses the contamination of water samples from Ranney well and other wells used by E.I. du Pont de Nemours and Company, indicating the presence of various pollutants, including carbon tetrachloride and chloroform, which could impact water quality standards and are discharged into the Ohio River without adequate treatment. 1999 AR226-2566 YGD5QR3n6VyrDE1kD2a5JGdBk 2
The document is a final report from the 3M Environmental Laboratory detailing the analysis of PFOA, PFOS, PFHS, and PFBS in groundwater samples collected from newly constructed wells at the Oakdale, Minnesota disposal site. 1999 AR226-3635 DDO2r3DoRkXLLyk03k5D4679n 18
The document is a final report from the 3M Environmental Laboratory detailing the analysis of groundwater samples for PFOA, PFOS, PFHS, and PFBS collected from newly constructed wells at the Oakdale, Minnesota disposal site. 1999 AR226-3641 VjaENae9O99Bxa99LdV4ZVLBp 18
The document is a final laboratory report from 3M Environmental Laboratory detailing the analysis of groundwater samples for PFOA, PFOS, PFHS, and PFBS collected from newly constructed wells at the Oakdale, Minnesota disposal site. 1999 AR226-3647 R2EeyvREJ4yKrp3EzpRxjoE7 18
The document is a laboratory report from 3M Environmental Laboratory detailing the analysis of PFOA, PFOS, PFHS, and PFBS in groundwater and surface water samples collected near the 3M Decatur facility, conducted under project number E06-0199 using a modified analytical method. 1999 AR226-3681 OEL0Qx1ZDNq9Kd9mVgdmYGxve 21