|
The document is a final report from SRI International assessing the mutagenic and recombinogenic activity of 3M Company's Compound T-3290CoC using in vitro assays, concluding that the compound was neither mutagenic nor recombinogenic.
|
1982 |
AR226-0222
|
MJ5M83JV6yeRJONN2ag2vy7D7 |
16 |
|
This document is a two-year oral toxicity and carcinogenicity study of the fluorochemical FM-3924 conducted by RIKER Laboratories, Inc. for 3M Company, detailing the methodology, results, and conclusions regarding its effects on rats.
|
1981 |
AR226-0257
|
Qj1YqX0LYQEN478rDXVRDB4R |
361 |
|
This document details an oral rangefinder study conducted by Riker Laboratories, Inc. on the substance T-2999CoC, sponsored by 3M Commercial Chemical Division, to determine the upper dose level for a subsequent teratology study in pregnant rabbits.
|
1981 |
AR226-0275
|
xdL8xX7ngN6pa4xv0KZEKNjgb |
10 |
|
The document reports on a two-year oral toxicity and carcinogenicity study of fluorochemical FM-3924 conducted by Riker Laboratories, Inc. for 3M Company, detailing macroscopic and microscopic observations of lesions and tissue changes in rats exposed to the substance.
|
1981 |
AR226-0258
|
RpyEYpKV4aoX2qM7x5p768oMk |
330 |
|
The document reports on an oral teratology study of T-2999CoC, sponsored by 3M, which found that while the compound was not teratogenic in pregnant rabbits, it exhibited embryotoxic effects at a high dose of 15 mg/kg/day, leading to increased abortions and poor neonatal survival.
|
1981 |
AR226-0276
|
6Ra1pyD9aqneNX0vaRryojndg |
37 |
|
The document reports on the analytical results of four corn oil samples containing varying concentrations of FM-3924, indicating that while the samples showed good reproducibility, the solubility of FM-3924 was low and crystallization could pose issues for a rat feeding study.
|
1981 |
AR226-0278
|
zXk1D3Gme2vybMjMj93r2dz7 |
1 |
|
The document details a two-year oral toxicity and carcinogenicity study of fluorochemical FM-3924 conducted by Riker Laboratories, Inc. for 3M Company, focusing on the effects of this compound on female rats.
|
1981 |
AR226-0261
|
v19DVe9EewM7mNkDxgVkkGdGm |
275 |
|
The document reports on a teratology study evaluating the effects of T-2999CoC on rat lenses during organogenesis, concluding that lens abnormalities observed were artifacts rather than compound-related effects, with no significant differences in histological appearance across dose groups.
|
1981 |
AR226-0282
|
0qYwRnKnk2vybOg15RxyjJMoJ |
21 |
|
This is a report on a Special Lens Oral Teratology Study of T-2999CoC conducted by Riker Laboratories, detailing the effects of the compound on fetal rat lenses across two strains of rats during gestation.
|
1981 |
AR226-0283
|
3NGDEoyvb05ZgX5baVE56B81O |
48 |
|
The document reports on the analytical results of four corn oil samples containing varying concentrations of FM-3924, indicating that while the samples showed good reproducibility, the solubility of FM-3924 was low and crystallization could pose issues for a rat feeding study.
|
1981 |
AR226-0285
|
6RvnYGLwezL1D2pDYZdz88Gwd |
1 |
|
The memo from K. G. Lamprecht discusses the misinterpretation of a fetal rat lens artifact as a teratogenic effect in Riker Experiments Nos. 0680TR0008 and 0680TR0010, detailing the nature of the lens abnormalities and the factors leading to the incorrect conclusion.
|
1981 |
AR226-0287
|
3Qa6xgkXLB6O9kDJ0eegzgz03 |
3 |
|
This document details a two-year oral toxicity and carcinogenicity study of the fluorochemical FM-3924 conducted by Riker Laboratories, Inc. for 3M Company, focusing on its effects in rats.
|
1981 |
AR226-0259
|
OzN0vLZ1rY12gZ8DwaVBObGXp |
339 |
|
The document details a two-year oral toxicity and carcinogenicity study of fluorochemical FM-3924 conducted by Riker Laboratories, Inc. for 3M, focusing on its effects in male rats from April 1981 to May 1983.
|
1981 |
AR226-0260
|
KzK5ZEm5oG0dRmqvgDGxJmZY2 |
325 |
|
The document reports on a Fluorochemical Control Study analyzing medical surveillance data from 1981 of Decatur chemical and film plant workers, finding no statistically significant correlations between various health markers and total organic fluorine levels, with a reference to perfluorooctanesulfonate as a component of total organic fluorine in the sera of some employees.
|
1981 |
AR226-0035
|
NEXaRQyNjRawgvRXVvBdvL9dQ |
9 |
|
This document reports on a toxicity study conducted by 3M Company in 1984, assessing the effects of perfluorooctanesulfonate (PFOS) on aquatic invertebrates, specifically Daphnia magna, with key findings indicating various EC50 values for immobilization and reproduction, although the study's reliability is noted to be limited due to unmeasured actual concentrations and un
|
1981 |
AR226-0110
|
zQ1VQEOMvDwoJyGmBNk16nVqm |
14 |
|
The memo discusses the misinterpretation of a fetal rat lens artifact as a teratogenic effect in Riker Experiments Nos. 0680TR0008 and 0680TR0010, detailing the morphological changes observed and clarifying that these changes were not indicative of teratogenicity.
|
1981 |
AR226-0329
|
jgKxdJz9YgZeD8Op2w34oeK99 |
3 |
|
The document presents fluorine measurement data for employees exposed to PFOS at a facility in Decatur, analyzing historical data from 1981 to 1997 and detailing the mean fluorine levels for groups of employees based on the number of measurements taken.
|
1981 |
AR226-0176
|
per89g0O3Ek5g6wpdw3aM8z47 |
12 |
|
The document reports on an acute oral toxicity study of T-3066CoC conducted on albino rats at Riker Laboratories, Inc., revealing an approximate LD50 of less than 5,000 mg/kg and greater than 500 mg/kg, with significant behavioral reactions observed at the higher dosage.
|
1981 |
AR226-0238
|
KJLNQo1rrLaOreq2gwKwznbVr |
10 |
|
The document reports on an acute oral toxicity study of T-3065CoC conducted on albino rats, revealing an LD50 greater than 5,000 mg/kg and noting adverse effects such as diarrhea and lethargy, along with gastrointestinal hemorrhage in deceased animals.
|
1981 |
AR226-0246
|
evEnygYGeLVQn6D8g9YB4KLaG |
9 |
|
The document discusses the comparison of two N-EtFOSE alcohols (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, detailing their compositions and production methods.
|
1980 |
AR226-0277
|
3emNzbvOnEM10pReogR7vDOBE |
1 |
|
The document reports on an oral teratology study of FM-3422, a compound found to be teratogenic in pregnant Sprague-Dawley rats, causing developmental abnormalities such as eye defects, cleft palates, and skeletal malformations at various doses, while not affecting embryonic viability or the reproductive health of the dams.
|
1980 |
AR226-0280
|
gbMdLJRJLyy0xDxa4VMBLKyw9 |
26 |
|
The document compares two formulations of N-EtFOSE Alcohol (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, detailing their compositions and production methods.
|
1980 |
AR226-0281
|
8522NRD9Rx8modkE22joBzkko |
1 |
|
The document compares two formulations of N-EtFOSE alcohols (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, detailing their compositions and production methods.
|
1980 |
AR226-0284
|
daQR524LnKj0Je9qp39Jdg87G |
1 |
|
The document reports on an oral teratology study of FC-95, sponsored by 3M, which found that administration of FC-95 to pregnant rats resulted in teratogenic changes in the lens of the eye, particularly at a dose of 10 mg/kg/day, while showing no embryotoxic effects or significant maternal toxicity at lower doses.
|
1980 |
AR226-0016
|
ppnMjNY2DjO9vVdGM1njy06Rk |
33 |
|
The document describes a compound-specific method developed by 3M Environmental Laboratory for the quantitative characterization of organic fluorochemicals, including PFOA and PFOS, in biological matrices using negative ion electrospray tandem mass spectrometry, aimed at improving detection and analysis of these compounds in humans and the environment.
|
1980 |
AR226-0191
|
373dRRqELxvwBNRLjNqJOMRo0 |
22 |
|
The document details the synthesis and characterization of carbon-14 labeled N-Ethyl FOSE (2-N-ethylperfluorooctanesulfamido ethanol) conducted by 3M and Riker Laboratories, reporting a specific activity of 0.483 ± 0.020 µCi/mg and a purity of at least 98%, indicating its suitability for metabolism studies.
|
1980 |
AR226-0268
|
ZnmNLkxJX28xx3xvDNV3exBa8 |
20 |
|
This document reports on pharmacokinetic studies of [14C]PFOS conducted on male Charles River CD rats, revealing that at least 95% of an oral dose was absorbed within 24 hours, with significant excretion observed in urine and feces, and no evidence of metabolic conversion of PFOS.
|
1979 |
AR226-0004
|
zDw6rbOoaOLkx1nY1Gg2wkx3 |
2 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-95-14c, a sulfonic acid salt produced by 3M's Commercial Chemicals Division, which was found to be at least 99% radiochemically pure and suitable for metabolism studies.
|
1979 |
AR226-0005
|
JJ9Vky2EjrRvky57wMygmdm8a |
18 |
|
This document reports on a study conducted by Riker Laboratories on the pharmacokinetics of FC-95, a perfluorinated sulfonic acid, detailing the excretion rates and tissue concentrations of carbon-14 in male rats following intravenous administration.
|
1979 |
AR226-0006
|
LpaL0Nor5z4GBExykobj0XaNq |
19 |
|
The document reports on a study conducted by Riker Laboratories, Inc. on the absorption and elimination of FC-95 (a potassium salt of a perfluorinated sulfonic acid) in male rats, finding that at least 95% of the carbon-14 from a single oral dose is absorbed within 24 hours, with a plasma elimination half-life of 7.5 days.
|
1979 |
AR226-0007
|
EqgBeddqQKvpj0EpYrZ6zE0aj |
18 |
|
The document reports on a biodegradation study of Perfluorooctanesulfonate (PFOS DEA salt) conducted by 3M Company, indicating that while the non-fluorinated moiety (2,2'-iminobis[ethanol]) is likely to biodegrade in aerobic conditions, the potential for biodegradation of the fluorochemical moiety remains uncertain.
|
1979 |
AR226-0059
|
yrDvjX2O9rye245O5X1GKkBDd |
11 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-0068
|
orjkDjxXEjrzLj4ozqoD3orr |
8 |
|
The document reports on an acute oral toxicity study of T-2574COC, a perfluorinated compound, conducted on albino rats by Riker Laboratories, indicating an approximate oral LD50 between 5,000 and 1,000 mg/kg, with notable behavioral reactions and mortality observed at the higher dosage.
|
1979 |
AR226-0294
|
3GBkGq86KEaK1KxON7O8m1d6 |
11 |
|
The document reports on an activated sludge respiration inhibition test conducted by 3M Company on perfluorooctanesulfonate (PFOS DEA salt), indicating that the test material showed no inhibitory effect at a concentration of 1000 mg/L over a 7-minute exposure.
|
1979 |
AR226-0116
|
VJ53yDreK8MRMYxOVYGp6MJLj |
4 |
|
The document is a 90-day subacute toxicity study of the fluorochemical surfactant FC-95 produced by 3M Company, conducted on rhesus monkeys to evaluate its effects on health.
|
1979 |
AR226-0138
|
a10QeG4JM489d3YbzqyMENby |
24 |
|
The document details a 1979 environmental sampling study conducted by 3M on fish from the Tennessee River to assess the bioaccumulation of N-Ethylperfluorooctanesulfonamide (EtFOSA), with specific sampling methods and fish types noted but lacking standardized guidelines.
|
1979 |
AR226-0343
|
dQBKGQNOLBD315gv84Qk2yoz6 |
36 |
|
The document reports on a 28-day percutaneous absorption study of FC-95, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, which found no mortalities but noted hyperactivity and body weight loss in some subjects, with preliminary serum analysis suggesting dermal absorption potential.
|
1979 |
AR226-0155
|
ExQ3ExXYGMEvVa1nRo6BmL8rx |
16 |
|
The document reports on a 28-day percutaneous absorption study of FC-99 conducted on albino rabbits at Riker Laboratories, Inc., which found no significant adverse effects but indicated potential dermal absorption of FC-99, although conclusive results could not be drawn due to limited serum analysis.
|
1979 |
AR226-0156
|
1ywjaEjZK6R7w2XOJ7J8K8dXm |
16 |
|
The report discusses the assessment of mitochondrial bioenergetics in rats treated with dietary FC10, highlighting that the use of pentobarbital for euthanasia confounded the ability to establish a dose-response correlation, and suggests alternative methods for analyzing metabolic dysfunction in exposed animals.
|
1979 |
AR226-0168
|
rrX7eyeJ9yNK2NzLVZrkK7e |
7 |
|
The document reports that SRI International conducted in vitro microbiological mutagenicity assays on 3M Company compounds T-2540 CoC and T-2541 CoC, finding that neither compound exhibited mutagenic or recombinogenic activity in any of the tested assays.
|
1979 |
AR226-0208
|
pmQNgke9QmD21oJ9n0m3Qmwqa |
23 |
|
A 28-day percutaneous absorption study of FC-129, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, Inc. revealed significant mortality and adverse behavioral reactions, indicating potential toxicity, though conclusive results on dermal absorption were limited due to the small sample size.
|
1979 |
AR226-0224
|
DMwqmQQ5vX0gYmKONoXgkVB6Q |
15 |
|
The document reports on a 28-day dermal absorption study of FC-128 conducted on albino rabbits at Riker Laboratories, Inc., indicating some dermal absorption but inconclusive results due to limited serum analysis.
|
1979 |
AR226-0223
|
10JMpYQLvb5OrEOvg7QO86Lja |
16 |
|
The document outlines a ninety-day subacute toxicity study on the compound FM-3422, conducted by the International Research and Development Corporation for 3M Company, focusing on its effects in rhesus monkeys.
|
1979 |
AR226-0256
|
2JE2MwjvXXdDzqwNzQJD8NZXN |
35 |
|
The document details a 1978 study by 3M Company investigating the bioaccumulation of perfluorooctanesulfonate (PFOS) in bluegill sunfish exposed to effluent from their Decatur, AL plant, which indicated the presence of PFOS in the fish exposed to the effluent while no fluorochemicals were detected in the control group.
|
1978 |
AR226-0061
|
N9Mr29wkDwgaJB44ZbReBB3V |
9 |
|
The document contains a series of ecotoxicity tests conducted by Wildlife International, Ltd. on PFOS, including various acute and chronic toxicity assessments with species such as the Fathead Minnow, freshwater algae, and Eastern Oyster, completed on April 26, 2000.
|
1978 |
AR226-0081
|
xzZE9E4oRD2daR1wNOe8aVvOE |
3 |
|
This document summarizes a 1981 toxicity study conducted by 3M Company on perfluorooctanesulfonate (PFOS) using the aquatic plant species Selenastrum capricomutum, reporting nominal EC50 values but noting issues with sample purity and statistical reliability.
|
1978 |
AR226-0106
|
gaK1ZdrGGbZNRV216v8qdY6ja |
18 |
|
This research report submitted to 3M Company examines the effects of continuous aqueous exposure to 14C-78.02 on the hatchability, growth, and survival of fathead minnow (Pimephales promelas) eggs and fry, finding that survival was the most sensitive indicator of toxicity with an estimated MTC value between >1.0 mg/L and <1.9 mg/L
|
1978 |
AR226-0108
|
zQ4bOD2oOVprdXrJ8qqJb4YX7 |
29 |
|
The document reports that in vitro microbiological mutagenicity assays conducted by SRI International on 3M Company compounds T-2247 CoC and T-2248 CoC found no mutagenic or recombinogenic activity in various strains of Salmonella typhimurium and yeast.
|
1978 |
AR226-0134
|
Gmx9Jb3w3jo4k07Dx23MzQLbn |
22 |
|
The document outlines a ninety-day subacute rat toxicity study conducted by the International Research and Development Corporation on the fluorochemical surfactant FC-95, sponsored by 3M Company, to assess its safety and biological effects.
|
1978 |
AR226-0139
|
ZJKnoKKNey7xBMajpxqy3E32p |
55 |
|
The document details a bioconcentration study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) using channel catfish to determine its aquatic bioconcentration factor, following a 3M derived method, although specific details on fish size, loading, and water chemistry are not provided.
|
1978 |
AR226-0352
|
NGrkBkbzbMvnMg50D6OR1bGkb |
7 |
|
The document details a 1978 study by 3M Company investigating the bioaccumulation of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol) in bluegill sunfish exposed to effluent from their Decatur, AL plant, finding 7 ppm of the substance in the effluent-exposed fish while none was detected in
|
1978 |
AR226-0354
|
JrrJvLBMX8d0axa0X45qBm8dZ |
10 |
|
The document outlines a ninety-day subacute rat toxicity study conducted by the International Research and Development Corporation for 3M Company on the compound FM-3422, detailing methodologies, observations, laboratory tests, and results related to its effects.
|
1978 |
AR226-0255
|
QkYbbB9kGa6ma5gJg0krBvLw7 |
53 |
|
The document summarizes studies conducted by 3M Company on perfluorooctanesulfonate (PFOS) from 1977 to 1979, detailing various tests on water solubility, biodegradation, soil sorption, and acute toxicity to aquatic organisms, while noting deficiencies in data quality and characterization of the test substance.
|
1977 |
AR226-0123
|
GKv0d1QJyvzod40p9k7jM5rQ7 |
16 |
|
The document reports on mutagenicity testing of various chemical samples using the Ames spot test, indicating that none of the samples tested, including those marked with an asterisk, showed mutagenic activity.
|
1977 |
AR226-0129
|
Qg2n0Yj4vwR4OXyq28rprBrEk |
1 |
|
The document details studies conducted by 3M on the soil adsorption properties of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol), indicating that it is likely to sorb to soil, although the studies lack methodological detail and data quality is rated low.
|
1977 |
AR226-0349
|
M43k94Dnwm85pYeOvE6O8nbRx |
7 |
|
The document details a bioconcentration test for N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) conducted on bluegill and channel catfish to determine its aquatic bioconcentration factor, using a static exposure method over specified periods without GLP compliance.
|
1977 |
AR226-0350
|
1g7NqaVm1p4r286rwxZX8kgQa |
17 |
|
The document details a soil adsorption study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), conducted in 1978, using specific methods to analyze its behavior in Brill sandy loam soil under controlled conditions.
|
1976 |
AR226-0348
|
np33V4jEG2Yy3ybeLe82kQNja |
14 |
|
The document details an acute toxicity test conducted on fish (Lepomis macrochirus) using a mixture of perfluorooctanesulfonate (PFOS DEA salt) in water, following EPA guidelines, to assess the effects of the substance on aquatic life over a 96-hour exposure period.
|
1975 |
AR226-0115
|
LJRGyYa928047oNkzQ8XxdOBq |
26 |
|
The report from WARF Institute, Inc. details the skin and eye irritation testing results for a product submitted by 3M Company, concluding that the product is not irritating to the skin but does cause eye irritation.
|
1975 |
AR226-0127
|
gDNq501oN87J8MnQkj8xZ8vb3 |
9 |
|
The document reports on an acute oral toxicity study conducted by Biosearch, Inc. for 3M Company on a substance identified as 3M Company - T-1388, which demonstrated an acute oral LD50 of less than 0.63 gm/kg in rats.
|
1975 |
AR226-0326
|
zQyYe96daKRq52GDe5MKxKzqz |
2 |
|
The document reports on a water solubility study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), conducted by 3M in 1977, which found that the substance has a solubility in the mid part per billion range, although the purity of the sample and testing conditions were not adequately characterized.
|
1975 |
AR226-0344
|
jgqeLoEDy5qQq9X3NvYdD4V4y |
5 |
|
The document outlines a research proposal by 3M and Johns Hopkins University to analyze serum samples for fluorochemicals, including PFOS and PFOA, from out-of-county residents in Washington County, Maryland, collected during the CLUE I and CLUE II studies in 1974 and 1989, to assess changes in levels over time.
|
1974 |
AR226-0020
|
qmobZzadDk8EmKvJNzKgxBwn |
6 |
|
The document reports on an acute toxicity test of Perfluorooctanesulfonate (PFOS) ammonium salt, produced by 3M, which found a 96-hour LC50 value of 100 mg/L for the fish species Pimephales promelas.
|
1974 |
AR226-0195
|
ExjdB008VgOMQGg3mQ8MZ6V4V |
11 |
|
The document reports on a biodegradation test of Perfluorooctanesulfonate, Ammonium salt (PFOS NH4+ salt) conducted by 3M Company, indicating that some portion of the substance biodegraded in aerobic environments, although the results primarily reflect the biodegradation of the isopropanol component rather than PFOS itself.
|
1974 |
AR226-0196
|
pLzzw8okN9En5111aQe0VLpE |
10 |
|
This document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Cleveland, Tennessee, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1973 |
AR226-0070
|
pZQqMeznZJYVRwdGEO3z8Rww |
8 |
|
The document reports on a primary eye irritation study conducted by 3M Company on a test material (T-2038CoC) using albino rabbits, concluding that the material is not a primary ocular irritant and requires no cautionary labeling.
|
1973 |
AR226-0292
|
bO5kMawoy8mZrveN5w7gKovpy |
3 |
|
The document reports on a primary skin irritation study conducted by 3M Company using a sample of T-2038CoC on albino rabbits to determine the degree of irritation produced when applied to intact and abraded skin.
|
1973 |
AR226-0293
|
xzj1V5e02epgp2NgaLZZbzag0 |
3 |
|
The document reports on histopathological examinations of fathead minnows (Pimephales promelas) exposed to 14C-78.02 for 30 days, submitted to 3M Company, detailing the methods and findings related to potential sub-lethal effects of the substance.
|
1973 |
AR226-0109
|
V3YMNZbR5GKoOK86g7Bgrzxe4 |
7 |
|
This document reports on a chronic toxicity study of perfluorooctanesulfonate (PFOS) conducted by E G & G, Bionomics for 3M Company, revealing a 30-day no observed effect concentration (NOEC) of 1 mg/L and a lowest observed effect concentration (LOEC) of 1.9 mg/L for the fish species Pimeph
|
1972 |
AR226-0107
|
Vj8RkBBb9oqb18mJQaz501yZj |
2 |
|
The document critiques 3M's bioaccumulation studies on FM3422 (N-Et FOSE alcohol) in bluegill sunfish and channel catfish, highlighting significant methodological flaws and lack of clarity regarding the substance's purity and the identification of the bioaccumulated material.
|
1970 |
AR226-0351
|
N2QbBrrma6QgmLL0dvpmmbgy8 |
8 |
|
The document outlines a protocol for an exploratory in-vitro absorption study of perfluorooctylsulfonate (PFOS) and ammonium perfluorooctanoate (PFOA) using the SkinEthic Reconstituted Epidermis Model, conducted by 3M's Corporate Toxicology Department.
|
1962 |
AR226-0182
|
gb6gRG7rzy2oY2nQ2OXLVem3V |
6 |
|
A retrospective cohort mortality study conducted by University of Minnesota epidemiologists on 3M employees at the Decatur, Alabama plant found no significantly elevated standardized mortality ratios (SMRs) for those exposed to perfluorinated compounds, with recommendations for an updated study to include additional mortality data.
|
1961 |
AR226-0032
|
EqDBZrpLYDGrpqO2x6azbY8Eg |
50 |
|
The document reports that a primary skin irritation test conducted on T-3493 at Riker Laboratories, Inc. found it to be non-irritating to the skin of female albino rabbits, with no signs of erythema or edema observed.
|
1934 |
AR226-0305
|
3JK5JwZDgeJNkEN3G91Oxky20 |
10 |
|
The document is a response from XENOS regarding FDA inquiries about a toxicity study on the chemical F n -3 9 2 4 conducted by RIKER Laboratories, addressing liver changes in rats and confirming that the original findings remain unchanged despite the FDA's request for additional data.
|
1931 |
AR226-0263
|
8RB49MjNRdMYXQeDgaBj7mdrK |
11 |
|
This document is a summary report of a 104-week dietary carcinogenicity study on N-Ethyl Perfluorooctanesulfonamido Ethanol (NEtFOSE) conducted by Covance for 3M, detailing the study design and initial findings through Week 53.
|
— |
AR226-0267
|
0egDe175pkJOXzLwrdKZb0nM |
345 |
|
This is a letterhead cover page from an unspecified laboratory, with no analytical content retained in the OCR.
|
— |
AR226-0289
|
2NdjeDQ5QBw82kjvBo1NKngzg |
7 |
|
This document outlines a method for analyzing potassium perfluorooctanesulfonate (PFOS) and other fluorochemical surfactants in serum extracts using HPLC-electrospray/mass spectrometry, detailing the applicable compounds and matrices for testing.
|
— |
AR226-0025
|
M4p6GXVp3VQomjdkJ9LvMzb5L |
9 |
|
This document outlines a study protocol by 3M to determine the serum elimination half-lives of perfluorooctanoate (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) in retirees from the Decatur Chemical Plant, involving biannual blood collections over five years.
|
— |
AR226-0023
|
dEMK9p7mYZEdqwveE7qKr9Mq |
20 |
|
This document outlines a laboratory method (ETS-8-6.0) for extracting potassium perfluorooctanesulfonate (PFOS) and other fluorochemical compounds from liver tissues using HPLC-Electrospray/Mass Spectrometry.
|
— |
AR226-0026
|
2qkKEJ56Ev4p5ppZnjd957pkp |
14 |
|
This document outlines a method (ETS-8-7.0) developed by 3M Environmental Laboratory for analyzing potassium perfluorooctanesulfonate (PFOS) and other fluorochemical surfactants in liver extracts using HPLC-electrospray/mass spectrometry.
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AR226-0027
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a1BM9b44xZ3k0j8jxdNNebkry |
10 |
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This document outlines a method for extracting potassium perfluorooctanesulfonate (PFOS) and other fluorochemical compounds from urine using HPLC-electrospray/mass spectrometry, detailing the procedure and applicable matrices for analysis.
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AR226-0028
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pe9xNrN0n7MM4VOxR3y3a5DOB |
14 |
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This document outlines a method (ETS-8-97.0) for analyzing potassium perfluorooctanesulfonate (PFOS) and other fluorochemicals in urine extracts using HPLC-electrospray/mass spectrometry, detailing the procedure and applicable matrices.
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AR226-0029
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6bQJbQn1JQmy5roLBDEQJ7er4 |
9 |
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This 3M technical report details the analysis of serum samples from Decatur employees, identifying perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS) as the primary organic fluorine compounds present, with PFOS contributing the largest percentage.
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AR226-0034
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g2kRdpgZXVRoZqy9rpbm0BGrQ |
4 |
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A serum fluorochemical assessment of 94 Sumitomo 3M employees revealed that production employees had the highest levels of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHS) at 0.628 ppm, 3.6 ppm, and 0.117
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AR226-0033
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KJewMoMMKNmER31n70XBknzr6 |
16 |
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This document reports on the photodegradation testing of perfluorooctanesulfonate (PFOS), indicating that after 30 days of simulated sunlight exposure, there was no degradation observed in the substance at a concentration of 50 mg/L.
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AR226-0056
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1gOzd813X5JOQXXGb36n3aDea |
17 |
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The document discusses biodegradation studies of PFOS (perfluorooctanesulfonate), indicating that both the Warburg and shake culture studies found no biodegradation of the substance, which is noted to be persistent, while new testing is being conducted to explore potential biological degradation mechanisms.
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AR226-0057
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15nOQ3eMmVx1222ngD9x2d37a |
32 |
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This analytical report from Centre Analytical Laboratories details the fluorochemical characterization of drinking water samples from Columbus, GA, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
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AR226-0065
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81EKnDOkvRrOBg96xw8MJe3y |
8 |
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This document outlines a method (ETS-8-154.0) for the determination of Perfluorooctane sulfonate (PFOS), Perfluorooctane Sulfonylamide (PFOSA), and Perfluorooctanoate (POAA) in water samples using liquid-solid extraction and high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS
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AR226-0064
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bBeOb39xk23pj6wRYmz9BJzZ |
17 |
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This analytical report from Centre Analytical Laboratories details the characterization of drinking water samples from Pensacola, FL, specifically analyzing for perfluorinated compounds including PFOS, PFOSA, and POAA using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
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AR226-0066
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Jvvzm8vnQ5nnR2Yv0beq0Zrk6 |
8 |
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This document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Port St. Lucie, FL, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using LC/MS/MS methods.
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AR226-0067
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y7bGKZyOqZoMZXkr9VXKJNOr |
8 |
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This analytical report from Centre Analytical Laboratories details the fluorochemical characterization of drinking water samples collected from Mobile, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
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AR226-0069
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NNN5zrpGvdpoELKekmQ1m3rz8 |
8 |
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The laboratory report from 3M details the LCMSMS analysis of PFOS in environmental samples, revealing that PFOS levels in fish samples were detected at low concentrations (< 5 ppb) and were approximately half of those previously reported, likely due to matrix interference affecting the original LCMS analysis.
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AR226-0078
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OGky9vY6d89J6KGvR0M34k6L |
6 |
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This document reports on an exploratory 28-day oral toxicity study of telomer alcohol and telomer acrylate, using PFHS and PFOS as positive controls, conducted on rats with a subsequent recovery period.
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AR226-0038
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dnqd8YOaEXyqyyOqr0D668yB6 |
446 |
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The document reports on a guinea pig maximization study conducted by Hazleton Laboratories to evaluate the acute toxicity of a test substance, identified as sample T-3609, for Minnesota Mining and Manufacturing.
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AR226-0307
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v16q16MeQqXXy0X779rV5q0RE |
23 |
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The document is a draft report for a 13-week dietary toxicity study of N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE, T-6314) conducted by Covance Laboratories for 3M, detailing the study's context and key personnel involved.
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AR226-0300
|
6bZQwmKzbQ9GxKJ5VMj2xdR8g |
554 |
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This laboratory report details the analysis of liver samples from six species of wild birds for the presence of PFOS and PFOSA, conducted by 3M Environmental Laboratory, revealing various fluorochemical contaminants across multiple geographic locations in the United States.
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AR226-0079
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byO4QedR1mo99Xx8YKyMwz940 |
10 |
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The document reports on the screening of PFOS levels in ten bird sera samples, revealing that juvenile bald eagles from Minnesota and Michigan contained 30-77 ppb of PFOS, while no PFOS was detected in Layson albatross samples from Midway Atoll.
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AR226-0080
|
rOgx65kdQaOvY1kDVbqxVZkJ |
6 |
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The document is a Quality Assurance Certificate for a mutagenicity study of 2-[N-ethyl-N-perfluoroalkyl(C=1~8)sulfonylamino]ethylacrylate conducted by BML, Inc., confirming compliance with Japanese standards and the accuracy of reported results.
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AR226-0309
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a1XKYKMdj51mkvjE7NGb6BpbB |
16 |
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The document reports on a guinea pig maximization study conducted by Hazleton Laboratories for U.C. McCormick, focusing on determining the appropriate dose levels of a test material, likely related to PFOA or PFOS, for topical application in toxicity testing.
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AR226-0315
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dnRm2pQ0mdrzmzyBJv4Zbo1Bb |
22 |
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The document reports on an in vitro mammalian cell gene mutation test evaluating the mutagenic activity of T-5869, a substance produced by 3M Belgium, conducted in compliance with Good Laboratory Practice standards.
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— |
AR226-0319
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mpqg1VnjZZpvkedo0n04nMM9J |
22 |