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CD 1 — AR226-0000-0354

EPA administrative record segment: CD-1--AR226-0000-0354 (335 documents).

Page 2 of 4 — 335 documents
Title / Summary Year AR226 Docket Hash ID Pages
This document reports on a dietary LC50 study of PFOS conducted with mallards by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and outlines compliance with Good Laboratory Practice standards. 1999 AR226-0103 vBVbookBKm9OazkoEQVxjqpG9 89
The document is a final report by Covance Laboratories detailing a study on chromosomal aberrations in human whole blood lymphocytes exposed to PFOS, submitted to 3M Corporate Toxicology, and conducted in compliance with EPA regulations. 1999 AR226-0131 ORY65b0Yo9jzv0z1qVxnB4xK 41
This document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA 1999 AR226-0332 jm1XYrym6rppKn0ezMEX56m1k 14
The document reports the melting point determination of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), indicating a melting point range of 55°C to 60°C, suggesting the presence of impurities in the sample. 1999 AR226-0347 2qBOjDqj9ED3pM3vKXDaJXbOg 3
This document is a second draft cell proliferation report detailing a 104-week dietary chronic toxicity and carcinogenicity study of perfluorooctane sulfonic acid potassium salt (PFOS) in rats, prepared by Pathology Associates International for 3M, and conducted in compliance with EPA Good Laboratory Practice regulations. 1999 AR226-0142 RpemneQDdrGom3BGKJqB808Yv 26
The document discusses a pathology review of a six-month toxicity study on PFOS conducted on monkeys, concluding that the deaths of two high-dose male monkeys were likely related to compound toxicity, with one showing signs of acute pneumonia and the other exhibiting liver changes indicative of toxicity. 1999 AR226-0150 7Ro5NYGZLygb9zogORJzv6wEe 2
The document is a pathology report detailing the results of a 26-week toxicity study on cynomolgus monkeys treated with perfluorooctane sulfonic acid potassium salt (PFOS), which found hepatocellular vacuolation and hypertrophy, primarily centrilobular, along with ultrastructural changes such as increased lipid droplets and glycogen in the liver. 1999 AR226-0149 rpVJdMomg28e2r63Zx4a9KoV7 60
This document reports on a study by Kendall B. Wallace investigating the inhibitory effects of selected perfluorochemicals, including PFOA and PFOS, on mitochondrial fatty acid oxidation using rat liver mitochondria. 1999 AR226-0170 15V8qykqdQ6XKVDdEboBbpx9q 4
This document outlines a pharmacokinetic study protocol by 3M to assess the oral absorption, clearance, and biological persistence of perfluorooctane sulfonyl fluoride (POSF) in rats, aiming to understand its metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes. 1999 AR226-0180 vENKmMxexLMrQY8p9oDMr92m 6
This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater alga Anabaena flos-aquae, to be conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines. 1999 AR226-0186 e5YwBk0xnVLx9QJEjwKOewRR4 16
This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater diatom Navicula pelliculosa, to be conducted by Wildlife International, Ltd. for 3M Corporation. 1999 AR226-0187 O15ne4DQLoK8ZJG4XenDe3B6e 17
This document outlines a protocol for a 96-hour toxicity test of PFOS using the marine diatom Skeletonema costatum, sponsored by 3M Corporation and conducted by Wildlife International, Ltd. 1999 AR226-0188 emZz48oxBQD8Kb9wZOMo58x79 17
The document outlines a protocol for a seven-day toxicity test of PFOS using duckweed (Lemna gibba G3), to be conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines. 1999 AR226-0189 7R8DwaQ6Jq6bGr9JMVqGOz0Na 18
The document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M Specialty Chemicals Division, to assess its oral absorption, clearance, and metabolism to PFOS for risk characterization. 1999 AR226-0209 JNk1LOxmny2127E4LvjqxdLBe 6
The document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA 1999 AR226-0215 bBvMkm1xZn4qOQaaw3KEQLm0y 14
The document is a review letter from Covance Laboratories regarding the mouse lymphoma cell mutation testing of 3M product T-6906, indicating that the study was technically inadequate and recommending a repeat of the assay to validly assess the mutagenic activity of the compound. 1999 AR226-0254 6bwwwrrbogBgN9mmnXqq9ZD46 3
The document is a final pilot report detailing an oral dosage-range developmental toxicity study of N-EtFOSE in rats, conducted by Argus Research Laboratories, Inc. under the direction of Dr. Raymond G. York. 1998 AR226-0272 B236vMERVaD99jVKyDZz6D9w 112
This document reports on a study conducted by Wildlife International Ltd. for 3M Corporation to determine the melting point/melting range of PFOS, completed in compliance with Good Laboratory Practice standards. 1998 AR226-0045 B8VV3en1b7o07OeEo9j6Mv6ew 14
The document outlines a protocol for determining the melting point/melting range of PFOS (perfluorooctane sulfonic acid, potassium salt) to be conducted by Wildlife International Ltd. for 3M Corporation, following OECD testing guidelines. 1998 AR226-0046 MoBML80JBMY25dnVvDjzQqJv7 9
The document outlines a protocol for determining the vapor pressure of PFOS (perfluorooctane sulfonic acid, potassium salt) using the spinning rotor gauge method, to be conducted by Wildlife International Ltd. for 3M Corporation following OECD testing guidelines. 1998 AR226-0049 LKjXjQvm2xnDody93p0XrzO3w 9
The document outlines a protocol for determining the water solubility of PFOS (perfluorooctane sulfonic acid, potassium salt) using the shake flask method, as requested by 3M Corporation and conducted by Wildlife International Ltd. 1998 AR226-0053 G6085webXBKrjbBB2rrKyer9n 10
This final report details a 96-hour static acute toxicity test of PFOS conducted on the fathead minnow (Pimephales promelas) by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization and stability determination. 1998 AR226-0083 LoXy3VMnZYa8dLjqbQnjoxJk3 58
This document is an amended final report on a 96-hour toxicity test of PFOS conducted with the freshwater alga Selenastrum capricomutum, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards. 1998 AR226-0085 5kY60e17ORK94jK69k9r4zZ0R 75
The document is an amended final report on a 48-hour static acute toxicity test of PFOS conducted with the cladoceran Daphnia magna, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards. 1998 AR226-0087 oe39jk8NjraxpJJqOX5J1bn8 55
The document is a final report on an activated sludge respiration inhibition test for PFOS conducted by Wildlife International Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practices while noting exceptions in substance characterization and stability assessments. 1998 AR226-0093 gDE8J5rVddZgna73y4GD2MRYQ 63
The document is an amended final report of a 96-hour static acute toxicity test conducted by Wildlife International Ltd. on PFOS (perfluorooctane sulfonate) using the saltwater mysid (Mysidopsis bahia), sponsored by 3M Corporation, and completed on June 24, 1999, with compliance to Good Laboratory Practice standards. 1998 AR226-0095 n9eyK2wXQM2jgmeL2Mw10BMwa 58
The document reports on the estimated boiling point of N-Ethylperfluorooctanesulfonamide (EtFOSA), a substance produced by 3M Company, based on extrapolated data from a vapor pressure study, indicating a boiling point of approximately 423°C at 760 mm Hg pressure. 1998 AR226-0334 Xz4VzEV2Mr26YEyG4O0ajRvJw 4
The document reports on a vapor pressure study of N-Ethylperfluorooctanesulfonamide (EtFOSA) conducted by AScI Corporation for 3M Company, indicating a vapor pressure of 0.142 Pa at 20°C, with a noted concern regarding the accuracy of the sample's 99% purity. 1998 AR226-0335 gDdBje6EVKO1zpXz3ozrxBLeJ 28
The document reports on an acute toxicity test of N-Ethylperfluorooctanesulfonamide (EtFOSA) on the fish species Pimphales promelas, detailing the test conditions and methods used, but does not provide specific results or findings. 1998 AR226-0337 XODe0RzY7dVG88OD174gE3kn4 10
The document reports on an acute toxicity study of N-Ethylperfluorooctanesulfonamide (EtFOSA) on Daphnia magna, detailing the test conditions and methods used to determine lethal loading values and NOEL, with nominal concentrations ranging from 5.8 to 45 mg/L. 1998 AR226-0338 B8LaqLBoE054XV99Y5KmB0oXX 9
The document reports on an acute toxicity test of N-Ethylperfluorooctanesulfonamide (EtFOSA) on the aquatic invertebrate Ceriodaphnia dubia, detailing the test conditions and nominal loading concentrations used to assess mortality. 1998 AR226-0340 LK4veEgJnqvymEe85bkYv2Vbb 9
The document details an activated sludge respiration inhibition test conducted on N-Ethylperfluorooctanesulfonamide (EtFOSA), assessing its impact on dissolved oxygen concentrations using activated sludge from Duluth, MN, with no recorded sample purity or lot number. 1998 AR226-0342 V3D6Zq64G1rkNxKbRyOkV7vDo 9
The document reports on the boiling point determination of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol) as part of a vapor pressure study conducted by 3M Company in 1998, indicating that the boiling points were extrapolated rather than empirically obtained. 1998 AR226-0345 JvxYJ80E6e5znbop96DBrr82a 4
The document reports on a vapor pressure study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), indicating that it is a stable white waxy solid with a purity of 99%, and concludes that the substance would primarily exist in the gas phase in the atmosphere, despite some concerns regarding data reliability and testing deviations. 1998 AR226-0346 MGGBYaa0YVdj1jorZ5ZXVGzEx 62
The document outlines the rationale for dose setting in a six-month chronic oral study of PFOS in Cynomolgus monkeys, highlighting a highly linear relationship between cumulative dose and serum concentration, with recommended dose groups of 0.0, 0.02, 0.15, and 0.75 mg/kg/day. 1998 AR226-0147 3x6qvOX1YwKv84gR81OjJ5Ga 13
The document is an unaudited draft final report of a 4-week capsule toxicity study on Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) conducted in Cynomolgus monkeys by Covance Laboratories for 3M, adhering to EPA Good Laboratory Practice Standards. 1998 AR226-0144 99bYjEpNe3vb9V73OGQkmmJL6 230
The document is an analytical report prepared for 3M Medical Department detailing the characterization of metabolites T-6292, T-6293, and T-6294 from rat and human hepatocytes, along with a semi-quantitative analysis of T-6295 using LC/MS and LC/MS/MS techniques. 1998 AR226-0163 VGKjryv46QEG14Nrw3De70ZrN 69
This is a cover page for a supplement of the journal "Toxicological Sciences," detailing various studies, including one on the cytotoxicity of particulate matter in Puerto Rico and another on the antitumor activities of coumarin and its metabolites. 1998 AR226-0172 mm2p6rrbYb8KZyVLV27LZ785O 3
This document outlines a preliminary ADME study of FC-129, sponsored by 3M Specialty Chemicals Division, aimed at assessing the absorption, distribution, metabolism, and excretion of the compound in rats to identify persistent metabolites. 1998 AR226-0227 B87EY6pgVq5ke0MDOvkNE9azm 1
This document is a pathology review assessing tumorigenesis data from a two-year study on the fluorochemical FM-3924, sponsored by 3M, to evaluate its chronic toxicity and carcinogenic potential in rats. 1998 AR226-0264 6Rx36MzXG80gZoXEvXmNrV4V3 7
The document is a final report from Corning Hazleton Inc. detailing a primary dermal irritation/corrosion study of the substance T-6684, sponsored by 3M, conducted in accordance with OECD guidelines. 1997 AR226-0321 4vaa39GQmXZQxjOvMQEvV68va 27
The document is a final report on a Primary Eye Irritation/Corrosion Study of T-6684, sponsored by 3M and conducted by Corning Hazleton Inc. in accordance with OECD guidelines, with a completion date of January 28, 1997. 1997 AR226-0322 LJr2o3erDo5J7en3Zxr28QXYz 31
The document is a quality assurance statement for a chromosomal aberration study of Sample D-1 conducted by the Kashima Laboratory of Mitsubishi Chemical Safety Institute, sponsored by Sumitomo 3M Limited, confirming adherence to GLP standards. 1996 AR226-0308 B5b4g916YXQKwMpn5dVanEw4E 17
The document is a final report on a mutagenicity test of T-6295 conducted by Coming Hazleton Inc. for 3M, which utilized an in vivo mouse micronucleus assay to evaluate the potential mutagenic effects of the substance. 1996 AR226-0130 kbg91O7Eea8LmKV75vxyJLDV 39
The document is a final report from Hita Research Laboratories, sponsored by Sumitomo 3M Limited, detailing a bacterial reverse mutation test (Study Code K01-1802) conducted on a substance referred to as T-1, in compliance with Japanese toxicity investigation standards. 1996 AR226-0136 3ez24K33M7DV511wJZLN770x3 29
This analytical report by Advanced BioAnalytical Services, Inc. investigates the in vitro metabolism of perfluorinated compounds T-6292, T-6293, T-6294, and T-6295 using rat and human hepatocytes with advanced LC/MS techniques. 1996 AR226-0328 5LezL7xBgavz5aaL1K7anQndD 45
The document is a final report from Hita Research Laboratories on a bacterial reverse mutation test for a chemical identified as u-1, sponsored by Sumitomo 3M Limited, conducted in compliance with Japanese toxicity investigation standards. 1996 AR226-0221 2jdeEwxaJjQojeVkd774n87Z6 23
The document is a final report of a mutagenicity test conducted by Corning Hazleton on a substance (not specified) using the Salmonella - Escherichia coli/mammalian-microsome reverse mutation assay, submitted to 3M, and confirms compliance with Good Laboratory Practice regulations. 1996 AR226-0232 N2g1vm7yweaBejDjE7G4MRvbD 30
The document is a final report on a mutagenicity test of a substance identified as T-6357, conducted by Corning Hazleton Inc. using an in vivo mouse micronucleus assay, submitted to 3M, and completed on April 23, 1996, confirming compliance with Good Laboratory Practice regulations. 1996 AR226-0233 xjeY61nK8ReZ6m9r58e9mrQNJ 27
The document is a final report on a mutagenicity test of T-6294 conducted by Corning Hazleton Inc. using an in vivo mouse micronucleus assay, submitted to 3M, and confirms compliance with Good Laboratory Practice regulations. 1996 AR226-0239 Dv1bvgzN5ZxmG5Zj7d6N3egzo 36
The document is a final report of a mutagenicity test conducted by Corning Hazleton Inc. on an in vivo mouse micronucleus assay for 3M, ensuring compliance with Good Laboratory Practice regulations and confirming no significant deviations that would affect the study's integrity. 1996 AR226-0252 oeEgo6vNmYg7wxJna0aExODNR 37
The document details the ion spray LC/MS determination of perfluoro analytical standards provided by 3M Medical Department, prepared by Advanced BioAnalytical Services, Inc. for toxicological analysis. 1995 AR226-0330 MxZ199kpRGnmEBXYde8j7yzL 60
The document outlines a study conducted by 3M Medical Department Toxicology Services to investigate the metabolism of specific test articles (T-6292, T-6293, T-6294, and T-6295) using isolated rat and human hepatocytes, with the aim of generating data for regulatory applications related to the Food and Drug Administration. 1995 AR226-0162 OEQOjbypXyvK6gRgwpGB5YkE1 10
The document reports on a blood testing program conducted in June 1995 at the Antwerp plant to measure individual exposures to PFOS and PFOA, comparing exposure levels within the facility and to other fluorochemical manufacturing sites, while also assessing various health parameters of the participants. 1995 AR226-0175 xdaLgoJ85VBLkV5bjJe7OyZ40 15
The document reports on a failed biodegradation study of Perfluorooctanesulfonate, Lithium salt (PFOS Li salt) conducted by Pace Laboratories for 3M Company, which could not produce usable carbonaceous BOD data after multiple attempts due to potential toxicity issues. 1994 AR226-0058 5LgjMJOjr9dXq5ZNL3nmd4DeV 4
The document reports on the evaluation of the mutagenic activity of T-5874 using the Ames Salmonella/microsome test, conducted by NOTOX B.V. in compliance with Good Laboratory Practice standards. 1994 AR226-0297 wKQjem3KmqK6Zpnboj6gEq9m3 24
The document reports on a study conducted by NOTOX evaluating the ability of the substance T-5874 to induce chromosome aberrations in cultured peripheral human lymphocytes, with compliance to Good Laboratory Practice standards. 1994 AR226-0298 bavpYVKXBDxow04M12v1Z4zxg 27
The document reports on the evaluation of the mutagenic activity of T-5874, a substance tested in an in vitro mammalian cell gene mutation test using L5178Y mouse lymphoma cells, conducted by NOTOX in compliance with GLP standards. 1994 AR226-0299 oqvBGw2yM9EE5Qn85Lex6dYR 23
The document is a final report on the analysis of T-5794 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations and detailing quality assurance inspections. 1994 AR226-0302 GmdqkyMYvb1vbRxRjDdw7KB94 37
The document is a final report on the analysis of T-5878 in a cell proliferation assay conducted on rat liver cells by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations. 1994 AR226-0303 km7bd09Lzke2mgKLpJKRdg77B 50
The document reports on a study conducted by NOTOX B.V. evaluating the ability of the substance T-5869, associated with 3M Belgium, to induce chromosome aberrations in cultured peripheral human lymphocytes, adhering to Good Laboratory Practice standards. 1994 AR226-0318 vBn5XQwo1VNQeLjxoYVLbpzQb 26
The document details an acute toxicity test of Perfluorooctanesulfonate (PFOS Li salt) on the fish species Pimephales promelas, conducted by Aquatic Biosystems Inc. in 1994, with a focus on determining the LC50 values over a 96-hour exposure period. 1994 AR226-0111 j1O1n8BrEKvD7eoXrDxgxEgp 9
The document reports on an acute toxicity test of Perfluorooctanesulfonate (PFOS Li salt) on the aquatic invertebrate Daphnia magna, finding a 48-hour EC50 value of 210 mg/L. 1994 AR226-0112 qaqKYyDY39kNkkjB3Dyw0nEeG 7
The document reports the results of a Microtox toxicity test conducted on a mixture of perfluorooctanesulfonate lithium salt (PFOS Li salt) in water, revealing an EC10 value of 564 mg/L and an EC50 value greater than 1000 mg/L for Photobacterium phosphoreum. 1994 AR226-0113 gbxDBwOnkOZJEgpg8YeXnKaVa 12
The document details an OECD 209 activated sludge respiration inhibition test conducted on Perfluorooctanesulfonate (PFOS Li salt) to assess its impact on oxygen consumption, noting issues with aeration during the test. 1994 AR226-0114 DvMaE7zaLJ9v0v3bMp15pbXEo 12
The document is a final report on the analysis of T-5877 in a cell proliferation assay using rat liver cells, conducted by Hazleton Washington, Inc. for 3M Corporation, confirming compliance with Good Laboratory Practice regulations and the integrity of the study results. 1994 AR226-0270 oe2EZKvRL7Z7JnpLppQpeE5XD 53
The document outlines a research protocol by 3M to analyze inpatient and outpatient claims data from Decatur chemical and film plant employees between 1993 and 1998, focusing on the health impacts potentially related to exposure to perfluorinated compounds. 1993 AR226-0022 Np7awd6K6oE2LGbN0956kBR8 19
The document is a final report on a genotoxicity test of T-5711.1 conducted by Hazleton Washington, Inc. for 3M Corporation, which assessed unscheduled DNA synthesis and cell proliferation in rat liver cells, ensuring compliance with Good Laboratory Practice regulations. 1993 AR226-0295 jBMdO22ZQmMGbXa9pY0KkgnQ2 46
The document is a final report of a mutagenicity test on T-5711 conducted by Hazleton Washington, Inc. for 3M Corporation, using an in vivo rat micronucleus assay to comply with U.S. EPA FIFRA guidelines. 1993 AR226-0296 DGoeebpOaXY9Q7KLZvX98O32M 41
This document outlines a method developed by 3M for the determination of N-Ethyl Perfluorooctanesulfonamide in air using silica gel sampling tubes and gas chromatography. 1993 AR226-0241 QJeyekQwjgoXbDxJ6LxJpZon7 2
The document is a final report on a mutagenicity test of T-5710 conducted by Hazleton Washington, Inc. for 3M Corporation, using an in vivo rat micronucleus assay to comply with U.S. EPA FIFRA guidelines. 1993 AR226-0250 LJkE0pKDYowJxLyk6qO38eJm3 26
The document is a final report on a genotoxicity test of T-5710.1, conducted by Hazleton Washington, Inc. for 3M Corporation, which evaluated unscheduled DNA synthesis and cell proliferation in rat liver cells, adhering to Good Laboratory Practice regulations. 1993 AR226-0251 OJy5RepLV66q5y8meD6L1eKLK 32
The document summarizes various reports and studies related to the characterization and toxicity of PFOS, including a robust summary from EnviroSystems of Resource Analysts, Inc., and multiple fluorochemical characterization analyses of drinking water samples from different cities. 1991 AR226-0062 mbr5okxVXk1VVvrQdDBpYoRo4 3
The document reports on a Microtox toxicity test for Perfluorooctanesulfonate (PFOS) in a test sample (FM-3820) showing a 30-minute EC50 value greater than 1000 mg/L, indicating low toxicity to the organism Photobacterium phosphoreum. 1991 AR226-0117 yrp5jLjgmJndVdaK9VL0j0EgV 7
The document details an acute toxicity test of Perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted according to OECD guidelines, with findings indicating the toxicity levels based on calculated EC50 values. 1991 AR226-0118 3QXJQGe0oYqnnykNobR5V2JEa 4
This document details a toxicity test of Perfluorooctanesulfonate (PFOS) on the aquatic plant species Selenastrum capricomutum, conducted using OECD 201 methods, with a focus on assessing the growth rate over a 96-hour exposure period. 1991 AR226-0121 Z8yL4qZX59kNxEYLXR98D509V 4
The document outlines a study protocol for a static acute toxicity test of the test substance FM 3820, sponsored by 3M Company, to determine the median effective concentrations (EC50s) affecting the daphnid species Daphnia magna over a 48-hour exposure period. 1990 AR226-0120 MJw57886zOyNnXqkkoanqQ3gx 61
The document is a final report from Hazleton Laboratories detailing an acute oral toxicity study of a test material (sample T-4102) administered to rats, conducted under OECD guidelines. 1988 AR226-0229 mqXoQ1yQ01RxRkw9z4jDmGBd 18
The document reports that a primary skin irritation test conducted on T-3874 at Riker Laboratories, Inc. found it to be non-irritating to the skin of female albino rabbits, with no signs of erythema or edema observed. 1986 AR226-0205 N23vQryYQ1Eym338Kr07XLEKy 10
The document is a final report on the in vitro microbiological mutagenicity assays of 3M Company's Compound T-3752, which was found to be reproducibly non-mutagenic and non-recombinogenic according to standard testing procedures. 1985 AR226-0247 O5pQ7b7qbayZLJM0kE4D9R6w 20
The document is a final report from Hazleton Laboratories America, Inc. detailing an acute oral toxicity study of the test material T-3727, which is associated with the Minnesota Mining and Manufacturing Company, conducted on Sprague-Dawley rats according to OECD guidelines. 1985 AR226-0245 YDQ27XZ4K83xB1xNGe12xQR9V 102
The document is a final report on the in vitro microbiological mutagenicity assays of 3M Company's compound T-3727, which concluded that T-3727 was reproducibly non-mutagenic when tested according to standard procedures. 1985 AR226-0248 8V4MO34EyKMOpDdODR9GRRxzK 16
The document reports that cholestyramine significantly enhances the fecal elimination of carbon-14 from ammonium [14C]perfluorooctanoate (PFOA) and potassium [14C]perfluorooctanesulfonate (PFOS) in rats, reducing liver concentrations of carbon-14 compared to control rats. 1984 AR226-0008 wqkx2z33YqQYONgL7MzvNDQ6E 3
The document reports the results of an acute ocular irritation test conducted on the substance T-3493, indicating it is minimally irritating to the eyes of female albino rabbits, with only minimal conjunctivitis observed that resolved within two days. 1984 AR226-0306 yr4YM238MJR6LpDK4KEM1Dp1D 12
The document is a final report from SRI International assessing the mutagenic activity of 3M Company's Compound T-3609 using the Ames Salmonella/microsome assay, concluding that the compound was nonmutagenic and nonrecombinogenic. 1984 AR226-0310 4JgGoNvz3bMbkEKx33YE24a61 18
The document reports on a primary skin irritation test of the substance T-3494 conducted on female albino rabbits at Riker Laboratories, indicating that T-3494 is slightly irritating to the skin with a score of 0.7/8.0. 1984 AR226-0313 bBLZ5689LgQ8R9DB3YoKvgJD3 10
The document reports the results of an acute ocular irritation test conducted on T-3494, indicating it is minimally irritating to the eyes of female albino rabbits, with no significant damage observed. 1984 AR226-0314 b8Ew9Ka5Q0OJkOep94O5dDmZ 12
The document is a final report from SRI International assessing the mutagenic and recombinogenic activity of 3M Company's Compound T-3610 using the Ames Salmonella/microsome assay and the Saccharomyces cerevisiae D3 assay, concluding that Compound T-3610 is nonmutagenic and nonrecombinogenic. 1984 AR226-0316 pmMYr0YkbNn4y7JYZmRm36YmE 18
The document reports on a biodegradation study of N-Ethylperfluorooctanesulfonamide (EtFOSA) conducted by 3M Company, indicating that the substance is not capable of readily biodegrading in aerobic environments, with a 20-day BOD result of less than 940 mg/kg. 1984 AR226-0336 ev3z6Y3JxorZ2dazYvD1E7b5q 4
The document reports on an acute toxicity study conducted by 3M Company in 1984, which found that N-Ethylperfluorooctanesulfonamide (EtFOSA) has a 96-hour LC50 of 34 mg/L for the fish species Pimephales promelas, although the study's reliability is questioned due to issues with sample purity and concentration measurements. 1984 AR226-0339 7Z3vDdVN3Rwd16YrGExxJDE8 5
The document reports on a toxicity study conducted by 3M Company in 1984, which found that N-Ethylperfluorooctanesulfonamide (EtFOSA) has an acute immobilization EC50 of 3.2 mg/L for daphnids, although the study's reliability is questioned due to unmeasured actual concentrations and inadequate sample purity characterization. 1984 AR226-0341 0LdkKGpDkeg0p80zEGX931zkk 5
The document reports on an acute inhalation toxicity study of T-3607, a perfluorinated compound (specifically perfluorooctyl sulfonyl fluoride), sponsored by 3M Company, which found no mortalities or clinical signs of toxicity in rats exposed to a concentration of 3.74 mg/L for four hours. 1984 AR226-0206 XRqRx8eKXxKqZnxqb17rj1okJ 12
The document reports that a primary skin irritation test conducted on T-3608 at Riker Laboratories, Inc. found it to be non-irritating to the skin of female albino rabbits, with no signs of erythema or edema observed. 1984 AR226-0237 NeJBwVd2dRYppoNRa8ny0ZOGp 10
The document discusses a safety evaluation study of the test substance T3351, indicating that while it causes severe maternal toxicity at higher doses, it has minimal adverse effects on fetal development, suggesting that as long as exposure is below toxic levels for adults, embryonic development remains unaffected. 1983 AR226-0015 5K4o7pN0aXKnrpGragEjqypR 2
This is a final report from Hazleton Laboratories America, Inc. for a Rat Teratology Study (Project No. 154-160) submitted to 3M Company on December 19, 1983, detailing the study's methodology, results, and quality assurance inspections. 1983 AR226-0014 zoYQkr5OLx6OMOQr6Zp5nkgG6 83
The document reports on an acute ocular irritation test of T-3421, a substance tested on female albino rabbits at Riker Laboratories, indicating that T-3421 is moderately irritating to the unwashed eye and mildly irritating under limited contact conditions, with various levels of irritation subsiding over time. 1983 AR226-0211 zo86dmLo7d7D9MOvv58NkGLwR 15
The document reports on a primary skin irritation test conducted on T-3421 at Riker Laboratories, which found that T-3421 is moderately irritating to the skin of female albino rabbits, with mild erythema and edema observed after a one-day occluded contact period. 1983 AR226-0212 YDGOXKEMVz1ZVqd9NXoB0BXm0 10
The document is an analytical report confirming that FM-3924, a perfluorinated compound, meets quality control specifications and is stable, as analyzed for Riker teratology study #0681TR0362. 1982 AR226-0279 wgxDnZmyxxykrwyb1x1Gabj8d 2
The internal correspondence details the analytical results of FM-3924, a perfluorinated compound, confirming its structure and composition for Riker's teratology study, with specific findings on isomer distribution and elemental analysis. 1982 AR226-0286 zo6bxEeJR6r2B3q4ngkQeLaE7 2
The document discusses a review of anatomical specimens related to a study on the effects of a test substance, revealing that previously reported abnormalities in fetal rat eyes were actually normal findings, indicating potential errors in the original study's conclusions. 1982 AR226-0017 YrvDkeVjq1pjxdwgR6md42V9n 2