|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to determine the inhalation approximate lethal concentration (ALC) of a substance identified as DuPont-12966 in rats, indicating its stability under study conditions.
|
— |
AR226-3285
|
pjraRMBL0XxowDK4M89mnGYB |
13 |
|
This document reports on a four-week inhalation toxicity study of a test substance conducted by E.I. du Pont de Nemours and Company, adhering to Good Laboratory Practice standards, to evaluate health effects in male rats.
|
— |
AR226-3282
|
YGK2pw5doM5kK3wG2ZD86NoKN |
214 |
|
The document is a final report on a 48-hour static acute toxicity test of Perfluorobutane Sulfonate (PFBS) conducted on the Cladoceran species Daphnia magna, submitted by Wildlife International, Ltd. to 3M Corporation, and compliant with Good Laboratory Practice standards.
|
— |
AR226-3748
|
5DE2B3d7xM5n82D89xyj4wE58 |
42 |
|
The document details a subchronic toxicity study (90-day gavage) conducted by E.I. du Pont de Nemours and Company on a test substance related to PFOA, adhering to U.S. EPA Good Laboratory Practice Standards, with evaluations including one-generation reproduction assessments.
|
— |
AR226-3286
|
d6GyprzkjB2Z529y00MOarB5 |
308 |
|
This document is a final report on a 96-hour toxicity test of PFBS (perfluorobutane sulfonic acid) conducted with the freshwater alga Selenastrum capricornutum, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards.
|
— |
AR226-3748
|
yrzDnDkz7o6o8393M9G4nxjpr |
57 |
|
This document is a final report on a semi-static life-cycle toxicity test of PFBS (perfluorobutane sulfonate) conducted with the cladoceran Daphnia magna, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards.
|
— |
AR226-3748
|
VJ45XwGjg4ZKgxNb3L4MrG4o8 |
81 |
|
The document is a final report on a flow-through bioconcentration test of Perfluorobutane Sulfonate (PFBS) using bluegill fish, conducted by Wildlife International, Ltd. for 3M Corporation, and it details compliance with Good Laboratory Practice standards, noting some exceptions regarding substance characterization and stability.
|
— |
AR226-3748
|
7Mw5BvZdZ282Gd7g7wyqRvepj |
100 |
|
The document reports a biodegradability study conducted by ELF ATOCHEM on a substance, which demonstrated 100% biodegradation within 5 days, indicating that the substance is easily biodegradable according to OECD guidelines.
|
— |
AR226-2999
|
3JmrVzjbvJ6M7OB6Ne31a948x |
28 |
|
The document reports on a static acute 96-hour toxicity test of the substance H-20431, conducted by DuPont at Haskell Laboratory, which demonstrated moderate toxicity to fathead minnows (Pimephales promelas) with 100% mortality at the highest tested concentration of 5000 mg/L.
|
— |
AR226-3004
|
3QnMgozYRypmjZZ0R2gdYp6en |
2 |
|
This document reports a range finding study on the aquatic toxicity of a substance (unspecified) using Daphnia magna, indicating that it exhibited moderate toxicity at a concentration of 5000 ng/L after 48 hours.
|
— |
AR226-3006
|
3N2R3bvaL42dKGyx1YgOvYwD0 |
2 |
|
The document reports on a study conducted by ELF ATOCHEM, authored by H. Thiebaud, which determined the acute toxicity of PFOA to Daphnia magna, revealing a median effective concentration (CE(I)50) greater than 100 mg/l after 24 and 48 hours of exposure.
|
— |
AR226-3008
|
gE5axYyJaDYw2ON0m8Or5w41N |
11 |
|
The document reports on a study conducted by ELF ATOCHEM to determine the acute toxicity of a substance (unspecified) to Daphnia magna, following ISO 6341 standards, finding a median effective concentration (CE(I)50) of above 100 mg/l at 24 hours and 13 mg/l at 48 hours.
|
— |
AR226-3009
|
v1ayz7gmowjxp29Jaya5pg0dZ |
14 |
|
The document reports on a study by ELF ATOCHEM assessing the bacterial inhibition effects of a substance on Pseudomonas putida, finding a 16-hour CE50 value of 18 mg/l and a CE10 value of 5.5 mg/l, indicating significant growth inhibition at these concentrations.
|
— |
AR226-3010
|
x0j27JKoN0KGgDOppJGZbzw0 |
11 |
|
The document reports on a study conducted by ELF ATOCHEM to determine the growth inhibition of Pseudomonas putida bacteria by a substance, revealing a 16-hour EC50 of 28 mg/l and an EC10 of 1.2 mg/l, with valid test conditions met.
|
— |
AR226-3011
|
2qLJOM38DD7Y2nxqy9bp2em8p |
11 |
|
This document reports on a rangefinding study assessing the aquatic toxicity of a substance (H-21095) using Daphnia magna, finding that it exhibited slight toxicity with a 48-hour EC50 between 50 and 500 mg/L.
|
— |
AR226-3019
|
a194367OOyOJxDNeMBVMLabQy |
2 |
|
The document reports a rangefinding study conducted by DuPont Specialty Chemicals on the aquatic toxicity of H-21095, which showed slight toxicity to fathead minnows with a 96-hour LC50 between 50 and 500 mg/L.
|
— |
AR226-3020
|
ExvV652ZB4E28ZE5EJ6xN9yxg |
2 |
|
The document reports on a study conducted by ELFATOCHEM to determine the bacterial growth inhibition of Pseudomonas putida when exposed to a substance, revealing a 14% inhibition at a concentration of 100 mg/l, indicating that the EC50 is higher than this concentration.
|
— |
AR226-3021
|
RJ5BQewOnagbqmpKL4OjLRVDv |
10 |
|
The document reports a biodegradability study conducted by ELFATOCHEM on a substance, indicating that it achieved 84% biodegradation in 28 days and is considered easily biodegradable according to OECD guidelines, with no inhibitory effects on microorganisms observed.
|
— |
AR226-3022
|
V3woY9VRbbd76D2RnMvGB8NnK |
21 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the biodegradability of a chemical using the Closed Bottle Test, which found that the substance did not meet the required 60% biodegradability threshold, achieving only 12.1% after 28 days.
|
— |
AR226-3025
|
x1MB60qm8mbggKEj2JB183NgG |
9 |
|
The document reports on a 96-hour acute toxicity screening test of the substance H-21209, conducted by DuPont Specialty Chemicals at Haskell Laboratory, which found that H-21209 exhibited slight toxicity to fathead minnows with a 96-hour LC50 estimated between 50 and 500 mg/L.
|
— |
AR226-3028
|
peEDvoqQRgY7q5pGNrKwQEkak |
2 |
|
This document reports on a rangefinding toxicity study conducted by DuPont on the compound H-21460 (a perfluorinated compound) using fathead minnows, indicating that the 96-hour LC50 was greater than 5000 mg/L with no mortalities observed at lower concentrations.
|
— |
AR226-3034
|
4arwL2ZBpxv6gY9V105bY4xbx |
2 |
|
The document reports on a study conducted by Elf Atochem to determine the growth inhibition of Pseudomonas putida bacteria when exposed to a specific substance, revealing a 16-hour median effective concentration (CE10) of 79 mg/l and a 16-hour lethal concentration (CES0) of 140 mg/l.
|
— |
AR226-3033
|
e19omqXQGoV2q61K9K8exkM6G |
5 |
|
The document reports on a study conducted by Elf Atochem S.A. to determine the acute toxicity of a substance to Daphnia magna, finding a median effective concentration (CE(I)50) of 100 mg/l after 48 hours, with the highest tested concentration being above 200 mg/l.
|
— |
AR226-3032
|
mBZMDg4mR2NObjynwkzZNNKkZ |
15 |
|
The document reports on a static acute 48-hour toxicity screening test of DuPont's H-21460 using Daphnia magna, indicating that the compound exhibited very low toxicity with an EC50 greater than 5000 mg/L.
|
— |
AR226-3035
|
6RM7M5BjRqgmGBKrQv93r4B94 |
2 |
|
The document reports on a biodegradability study of a substance conducted by ELF ATOCHEM, indicating that the substance achieved 48% biodegradation in 28 days and is considered easily biodegradable according to OECD guidelines.
|
— |
AR226-3040
|
7R4mmwM4mM0epRMye4e260KNo |
25 |
|
The document reports a static acute 96-hour toxicity test of the substance H-21952, conducted by DuPont, which found that it exhibited low toxicity to fathead minnows (Pimephales promelas) with a 96-hour LC50 between 500 and 5000 mg/L.
|
— |
AR226-3062
|
6wk6JJ4ZqnQK1r742eVrMpDZ9 |
2 |
|
The document reports on a 48-hour static acute toxicity test of the substance H-21952, conducted by DuPont at Haskell Laboratory for Toxicology, which found that H-21952 exhibited low toxicity to aquatic organisms, with an EC50 estimated between 500 and 5000 mg/L.
|
— |
AR226-3063
|
6pYRzxKwovBKopbx7My7aVo6 |
2 |
|
The document reports on a static acute 96-hour toxicity test of the substance H-21954 conducted by DuPont, which found that it exhibited low toxicity to fathead minnows (Pimephales promelas) with a 96-hour LC50 between 500 and 5000 mg/L.
|
— |
AR226-3064
|
byzr0MXeM72vVBR5bRRDpJ866 |
2 |
|
This document reports on a static acute 48-hour screening test of the substance H-21954, conducted by DuPont, which assessed aquatic toxicity on Daphnia, indicating that the substance exhibited toxicity at concentrations between 50 and 500 mg/L.
|
— |
AR226-3065
|
GmwB749ExY0mjBBLmw6V6ENnq |
2 |
|
The document reports on a static acute 48-hour toxicity screening test of PFOA using Daphnia magna, conducted by DuPont, which indicated slight toxicity at various concentrations.
|
— |
AR226-3102
|
oeJ5zyL6nwGYGNOzQXg1QMpL8 |
2 |
|
This is a final report (DPT434/984093) from Huntingdon Life Sciences Ltd. on a bacterial mutation assay sponsored by DuPont Specialty Chemicals, issued on October 1, 1998.
|
— |
AR226-3101
|
DGeGJ6KjLz1OQMZVVQJk63OMB |
27 |
|
This document is a report on an in vitro mammalian chromosome aberration test conducted on human lymphocytes by Huntingdon Life Sciences Ltd. for DuPont Specialty Chemicals, assessing the genotoxicity of a test substance related to PFOA or PFOS.
|
— |
AR226-3103
|
2DX4JD0ZomVBqZ0rxyEk7Q3L |
28 |
|
The document is a report from Huntingdon Life Sciences Ltd. regarding a study on a test substance related to PFOA, conducted for DuPont-Speciality Chemicals, which complies with Good Laboratory Practice standards.
|
— |
AR226-3107
|
QaQmQOK9jJ6k6vbKob6aEG8o |
14 |
|
The document is a final report from Huntingdon Life Sciences Limited on an activated sludge respiration inhibition test for a substance sponsored by DuPont Specialty Chemicals, conducted in compliance with Good Laboratory Practice standards.
|
— |
AR226-3106
|
qaomjyNbLbOMZ24EjGg6JynxG |
18 |
|
The document is a final report from Huntingdon Life Sciences Ltd assessing the ready biodegradability of a test substance related to Dupont Specialty Chemicals, conducted under Good Laboratory Practice standards, with results indicating the degradation of the test substance.
|
— |
AR226-3108
|
aBE32dypz1bZbv73ZKGz2e1kR |
20 |
|
The document reports on a preliminary test conducted by DuPont Specialty Chemicals and Huntingdon Life Sciences to evaluate the hydrolysis of a test substance, likely related to PFOA or PFOS, as a function of pH, in compliance with Good Laboratory Practice standards.
|
— |
AR226-3112
|
jBR46LKkoMMp4zRG4ooVp3GDy |
18 |
|
The document outlines a study conducted by Huntingdon Life Sciences on the physico-chemical properties of a substance sponsored by DuPont Specialty Chemicals, ensuring compliance with Good Laboratory Practice standards.
|
— |
AR226-3113
|
jGJd3D0Vozw8yq0RZ7wQ64wQ |
33 |
|
The document is a report on a mouse micronucleus test conducted by DuPont Specialty Chemicals to assess the genotoxicity of a test substance, likely related to PFOA or PFOS, at Huntingdon Life Sciences.
|
— |
AR226-3115
|
3QdEE0QQrqygG4OgLNZneqvNy |
26 |
|
The document is a draft report from DuPont Specialty Chemicals detailing an acute toxicity study of PFOA on Daphnia magna, conducted by Huntingdon Life Sciences, with results and conclusions regarding the substance's environmental impact.
|
— |
AR226-3116
|
Gzjdr73gVg885woaeNaoe5Bam |
29 |
|
The document is a draft report from DuPont Specialty Chemicals detailing an algal growth inhibition assay conducted by Huntingdon Life Sciences, which assesses the effects of a test substance on algal growth, with results and conclusions provided.
|
— |
AR226-3117
|
vBDz46QVkb46ae990y6BLkOQ9 |
30 |
|
This is a draft report (DPT439/984974) from Huntingdon Life Sciences Ltd. on acute toxicity to fish, sponsored by DuPont Specialty Chemicals, conducted in compliance with Good Laboratory Practice standards.
|
— |
AR226-3118
|
NE9MRegzyKymv5Mn7vr0Z9XDD |
28 |
|
The document reports on a study conducted by DuPont Specialty Chemicals assessing the acute dermal toxicity of a test substance to rats, compliant with Good Laboratory Practice standards.
|
— |
AR226-3121
|
ZBvqJ12arpGnojVv9X8Z5Bwd7 |
17 |
|
The document reports on a study sponsored by ELF ATOCHEM, conducted to determine the chronic toxicity of an unspecified perfluorinated compound on the growth inhibition of freshwater algae Pseudokirchneriella subcapitata, revealing a NOEC of 1.9 mg/l for biomass and 9.4 mg/l for growth rate after 72 hours of exposure.
|
— |
AR226-3120
|
kDk2m8V8z0gd87aOe30m3e0Vb |
36 |
|
This document is a submission to the EPA's IRIS and AR-226 database regarding PFOA/PFOS in response to a notice issued by the EPA on February 23, 2006.
|
— |
AR226-3888
|
VK2Q3J0E7aN6xen44mm4pazQg |
40 |
|
This document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a test substance (likely PFOA or PFOS) over a 90-day period, including one-generation reproduction assessments.
|
— |
AR226-3288
|
Y6a8BkdaaBe9JQykOe8YmejD |
327 |
|
The document reports on a static, acute 96-hour toxicity screening test of the substance H-25914, conducted by E.I. du Pont de Nemours and Company, which evaluated its effects on the rainbow trout, Oncorhynchus mykiss.
|
— |
AR226-3291
|
zoYRj0jM43dDMO0q5MRY4QOEg |
9 |
|
The document reports on a static, acute 48-hour toxicity screening test conducted by DuPont on the substance H-25914, assessing its effects on Daphnia magna, with findings indicating the test substance was stable and did not exhibit toxicity at the tested concentrations.
|
— |
AR226-3292
|
O1r1xRg1L867y6Oz1R4e2jkwL |
9 |
|
The document reports on a subchronic toxicity study of PFOA conducted by DuPont, detailing the microscopic observations and incidences of non-neoplastic lesions in male rats after 90 days of gavage treatment.
|
— |
AR226-3287
|
ev6JNQwdKgYaqBm10NZGyD1Eq |
436 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a perfluorinated compound over 90 days, including individual animal observations and histopathological findings.
|
— |
AR226-3289
|
3Qb2xZdZeKaKknLEzwjdv7aMy |
348 |
|
The document is a study report by E.I. du Pont de Nemours and Company detailing a 28-day repeated dose dermal toxicity study in male rats, conducted under U.S. EPA and OECD guidelines, to evaluate the effects of a test substance characterized as a trade secret.
|
— |
AR226-3293
|
np4R7KbYOvOnpx5B8Qng8gw5w |
204 |
|
The document details a subchronic toxicity study conducted by DuPont on male rats, evaluating the effects of a 90-day gavage exposure to a substance, likely related to PFOA or PFOS, with specific focus on sperm and spermatid counts.
|
— |
AR226-3290
|
7OvgneD6YGGyZX0Rd6oeJgb68 |
362 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to assess the influence of the substance H-25914 on the growth and growth rate of the green alga Selenastrum capricornutum, revealing effects at various concentrations over a 72-hour exposure period.
|
— |
AR226-3294
|
1qEXgpoZQx8aEBOo0Kqzn40Z |
20 |
|
The document details a biocompatibility study (H-25878) conducted by North American Science Associates, Inc. for E.I. du Pont de Nemours and Company, focusing on the cytotoxicity of a substance related to PFOA/PFOS, with the study completed on August 26, 2003.
|
— |
AR226-3295
|
Yj4mEgNMb87DVXOGNevOz1Gbk |
30 |
|
This document is a report on a 90-day subchronic toxicity study of PFOA conducted by DuPont on male rats, authored by Linda A. Malley, Ph.D., and completed on September 4, 2003.
|
— |
AR226-3297
|
rBpX2xJ1ZrMyYv7eBYaMvb5Z0 |
50 |
|
The document reports on a 28-day repeated-dose dermal toxicity study of a substance conducted by E.I. du Pont de Nemours and Company, focusing on male rats, in compliance with U.S. EPA and OECD guidelines.
|
— |
AR226-3296
|
ppzZoYYVK1K2ddb7XyMyjxmQw |
158 |
|
The document outlines the decision by the Persistent Organic Pollutants Review Committee to further evaluate the proposal by Sweden to list perfluorooctane sulfonate (PFOS) and its precursors under the Stockholm Convention, confirming that screening criteria have been met and establishing a working group to prepare a draft risk profile.
|
— |
AR226-3614
|
ZQ7Q2zBenNJMDGXMja7DYg8L |
3 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company, led by Dr. Michael P. DeLorme, to determine the inhalation approximate lethal concentration (ALC) of a substance identified as DuPont-13308 in rats, completed on September 9, 2003.
|
— |
AR226-3299
|
dYBpnz6ba3R4Q46nn7b9xNodq |
12 |
|
The document reports on a study commissioned by DuPont KK to evaluate the accumulation of a perfluorinated compound in carp, conducted by the Chemicals Evaluation and Research Institute in Japan, with preliminary tests indicating acute toxicity.
|
— |
AR226-3300
|
J30vKx7MojzRz482V5rGo4JJ2 |
19 |
|
The document is a study report by E.I. du Pont de Nemours and Company on the early life-stage toxicity of a test substance to rainbow trout (Oncorhynchus mykiss), conducted in compliance with U.S. EPA Good Laboratory Practice Standards.
|
— |
AR226-3298
|
LpkYNma5JzNQLZjqY1pyeMkQQ |
138 |
|
This document is a study report commissioned by DuPont KK analyzing impurities in a non-GLP study context, specifically related to perfluorinated compounds.
|
— |
AR226-3301
|
KG12N20ZgQkB2QLGRYg2x1OKr |
9 |
|
This is a study report from the Chemicals Evaluation and Research Institute in Japan (Study No. 33620) commissioned by DuPont KK, analyzing the residual solvent ethanol in Forafac 1157 using gas chromatography, with results indicating 0% ethanol content.
|
— |
AR226-3302
|
1y9w1GYeGnOB6dGE7roVw5YX |
12 |
|
The document is a study report from the Chemicals Evaluation and Research Institute in Japan, detailing a non-GLP study on the biodegradation of perfluorinated compounds by microorganisms, specifically focusing on the methodology and results related to the test substances involved.
|
— |
AR226-3303
|
91xwaGjRQdrg2g87aBVBEjpXe |
23 |
|
The document reports on the stability analysis of the test substance H-24921, a perfluorinated compound, conducted by DuPont's Haskell Laboratory, confirming the active ingredient's purity within the expected range based on high-performance liquid chromatography/tandem mass spectrometry methods.
|
— |
AR226-3304
|
La9K6zZm6YxMvJqr0MkvV4Vd |
5 |
|
The document details the stability analysis of the test substance H-24921, a perfluorinated compound produced by DuPont, using high-performance liquid chromatography/tandem mass spectrometry, with results indicating nominal concentrations for further studies.
|
— |
AR226-3305
|
ExwJBJd5mgx1jY3zLqawO0e2N |
5 |
|
The document details a study conducted by E.I. du Pont de Nemours and Company on the influence of a test substance on the growth and growth rate of the green alga Selenastrum capricornutum, adhering to OECD and EPA guidelines.
|
— |
AR226-3306
|
npx6e4nEnkd1QpxpmQyRJ0kn8 |
60 |
|
This document is a report on an acute oral toxicity study of a test substance conducted by DuPont Specialty Chemicals at Huntingdon Life Sciences, focusing on the effects of the substance on rats.
|
— |
AR226-3122
|
MoymK43J0Q63bypwRNK1V6dgz |
18 |
|
This is a DuPont analytical report (H-24108) detailing a static acute toxicity test on Daphnia magna, which concluded that the substance exhibited low toxicity at various concentrations.
|
— |
AR226-3123
|
xzNRaxmKLQnML0y6Eq84RzJX1 |
2 |
|
This document reports on a static acute 48-hour screening test conducted by DuPont Specialty Chemicals to assess the aquatic toxicity of a substance on Daphnia magna, revealing varying levels of clarity and suspended substances in the test solutions across different concentrations.
|
— |
AR226-3124
|
e75xZnLLgjDOyjyBM93aoM2Y4 |
2 |
|
This is a DuPont analytical report detailing a 96-hour acute toxicity test of H-24119 on Fathead minnows, indicating low toxicity levels.
|
— |
AR226-3125
|
JrkpOkmZQD9oQn3xdGqQn8g2K |
2 |
|
The document outlines a study conducted by Huntingdon Life Sciences on the partition coefficient and adsorption/desorption properties of a test substance, sponsored by DuPont Specialty Chemicals, in compliance with Good Laboratory Practice standards.
|
— |
AR226-3133
|
44o9YyGxVRqZvX5wG0O3K0Gv1 |
12 |
|
The document discusses historical data on C-8 (PFOA) exposure among workers at Washington Works, noting that while C-8 was found in the blood of exposed workers, no significant health issues or disease incidence were linked to the exposure, and it highlights the correlation between blood and air levels of C-8.
|
— |
AR226-3760
|
v1ZJ6oKB2Oap1DQQ0VEkmVZw9 |
11 |
|
The document reports on a static acute toxicity test of DuPont's H-24390 using Daphnia magna, indicating that the substance exhibited low toxicity with a 48-hour EC50 greater than 1000 mg/L.
|
— |
AR226-3145
|
MMnXqOkNOY56ZkwKnerxKy43z |
2 |
|
The document reports on a 96-hour acute toxicity test of PFOA conducted by DuPont at Haskell Laboratory, which found that H-24390 exhibited medium toxicity to fathead minnows (Pimephales promelas) at various concentrations.
|
— |
AR226-3146
|
X73npkwpy1899kbrXmz2JBZBw |
2 |
|
This document presents the results of a chromosomal aberration test using mammalian culture cells, specifically detailing the conditions and materials used in the study, but does not mention PFOA or PFOS.
|
— |
AR226-3307
|
KR555nnjXwZE9pawJ5wn3d2Dr |
21 |
|
The document outlines a study conducted by E.I. du Pont de Nemours and Company on a perfluorinated compound, adhering to Good Laboratory Practice Standards, with a focus on the characterization of the test substance, which included an analysis of its percent content of PFOA.
|
— |
AR226-3308
|
Ran8KGg9RNZDqVnwmkB34oOOE |
35 |
|
The document is a final report on an in vitro mammalian chromosome aberration study conducted by BioReliance for E. I. duPont de Nemours and Company, focusing on the effects of a test substance, likely related to PFOA or PFOS, on human peripheral blood lymphocytes, with compliance to Good Laboratory Practice standards noted.
|
— |
AR226-3309
|
peZRj6mo9bGEvap7VzJm1MyrB |
40 |
|
This document is a study report from DuPont titled "Biopersistence Screening 10-Dose Oral Gavage Study in Rats," which evaluates the biopersistence of a substance, likely related to PFOA or PFOS, completed on November 26, 2003.
|
— |
AR226-3310
|
qw30p61eB1kz3ybEBqoZgOrE |
82 |
|
The document reports on a 28-day repeated administration toxicity study of a novel chemical substance, identifying a No-Observed-Effect Level (NOEL) of 50 mg/kg/day in rats, with observed soft stool in higher dosage groups.
|
— |
AR226-3311
|
NN0yw8eMo5Np27GNY9JXOEaR |
110 |
|
The document summarizes a bioconcentration study report for a novel chemical substance, detailing its properties, acute toxicity testing on killifish (Oryzias latipes) with an LC50 value greater than 35.0 mg/L, and the methodology used for testing bioconcentration in fish, specifically following OECD guidelines.
|
— |
AR226-3312
|
rB3RQgVMoKoNJvNGRYK48DBaE |
38 |
|
This document is a supplement to a 28-day repeated-dose dermal toxicity study of male rats conducted by E.I. du Pont de Nemours and Company, focusing on the health effects of a perfluorinated compound, with quality assurance details included.
|
— |
AR226-3313
|
V8e7920gMxoD7krvKM41z3g4 |
83 |
|
The document is a supplement to a subchronic toxicity study (H-25425) conducted by E.I. du Pont de Nemours and Company, evaluating the effects of a perfluorinated compound on rats over 90 days, including one-generation reproduction assessments, in compliance with U.S. EPA Good Laboratory Practice Standards.
|
— |
AR226-3315
|
k9yZXnD32LDNr46JX5dEGaYeB |
98 |
|
This document details a developmental toxicity study conducted by DuPont on rats, following U.S. EPA and OECD guidelines, to assess the effects of a test substance related to perfluorinated compounds, specifically under the project ID DuPont-10157.
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— |
AR226-3314
|
Moad4BNKDknOkygVEXY0pDgaa |
165 |
|
The document details a study conducted by E.I. du Pont de Nemours and Company on the hydrolytic stability of a substance identified as H-24616, assessing its stability as a function of pH, in compliance with U.S. EPA TSCA Good Laboratory Practice Standards.
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— |
AR226-3317
|
ZJJXN9bM4z5dB8Npo3oOJ7qap |
44 |
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The document reports on a 28-day repeated dose dermal toxicity study of a substance related to E.I. du Pont de Nemours and Company, conducted in compliance with U.S. EPA Good Laboratory Practice Standards, focusing on the effects of a melt additive incorporated into test fabrics.
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— |
AR226-3316
|
mpXYavaOmnYye384RjB0LR614 |
196 |
|
The document details a study (H-25436) conducted by E.I. du Pont de Nemours and Company on the early life-stage toxicity of a test substance to rainbow trout (Oncorhynchus mykiss), adhering to U.S. EPA and OECD guidelines, with compliance to Good Laboratory Practice standards.
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— |
AR226-3318
|
per3yeek5zRbdK3wKNrdzokgX |
138 |
|
The document is a study report by E.I. du Pont de Nemours and Company on the hydrolytic stability of the substance H-25435 as a function of pH, conducted in compliance with Good Laboratory Practice standards.
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— |
AR226-3319
|
mb9zZkyNeZEngBw8O1OyBN15k |
46 |
|
This document appears to be a draft from DuPont discussing the distributions of perfluoroalkyliodide homologues and their production processes, but it contains no analytical content due to extensive sanitization.
|
— |
AR226-3322
|
m2N1g1eXDJXkqk6e904aXRdk |
13 |
|
This document appears to be a summary of conclusions and current program status from DuPont, with references to confidential information and ongoing workstreams, but lacks specific analytical content due to sanitization.
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— |
AR226-3325
|
8V4b161yg2Eq94KDx3Gbyap0k |
14 |
|
Unreadable document.
|
— |
AR226-3326
|
dDmzB2wr2NbkwgxkYVakp1zD6 |
10 |
|
The document details a 28-day repeated-dose dermal toxicity study of a test substance conducted by E.I. du Pont de Nemours and Company, adhering to U.S. EPA and OECD guidelines, but with some analyses performed outside Good Laboratory Practice standards.
|
— |
AR226-3321
|
dQeVzV6yY8KoO1z6mz9dKdrm0 |
251 |
|
The document discusses the measurement of residual C-8 fluorosurfactant levels, specifically "Fluorad" FC-143, in various products produced by 3M Company following teratogenicity concerns, indicating that very low levels (1-5 ppm) of C-8 APFC were detected in unextruded fluoropolymer resins.
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— |
AR226-3333
|
k27X1k0GNREXDXXXNBV0Jjkn |
4 |
|
The document details analytical method developments for the determination of ammonium perfluorooctanoate (APFO) by DuPont Fluoroproducts, including revisions to gas chromatographic methods for dry resin and air samples, as well as a rapid liquid chromatography method for aqueous samples.
|
— |
AR226-3336
|
X7dvRGRYn4BKq3xEpjypMk7Nw |
11 |
|
The document outlines the development of a new extraction and detection method for APFO (perfluorooctanoic acid) from PTFE samples, revealing that the maximum residual amount found in tested samples was 30 ppb, which corresponds to a potential migration of 0.025 mg/kg in food simulants, below the regulatory limit.
|
— |
AR226-3337
|
6Bd3K00gM6nJVNgY97GD7yoo3 |
2 |
|
The document discusses the acute and chronic toxicity of ammonium perfluorooctanoate (APFO, a salt of PFOA) in various aquatic organisms, highlighting the need for standardized toxicity data to meet regulatory guidelines and Good Laboratory Practice.
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— |
AR226-3339
|
oDV4eRY9VGY8Z7gxDQ4r6ZnxE |
7 |
|
The document is a final report from the Kurume Laboratory Chemicals Evaluation and Research Institute in Japan detailing a bioaccumulation test of Perfluorooctanoic acid (PFOA) in carp, conducted under Good Laboratory Practice standards.
|
— |
AR226-3338
|
1gMNG579XdJMvqMoMZqgy5Zno |
74 |
|
The document discusses environmental fate studies of fluorotelomer intermediates used by DuPont to produce surfactants and polymers, focusing on their physical-chemical properties, aqueous stability, and transformations relevant to toxicity and chemical cycling.
|
— |
AR226-3342
|
6w1owL0eNvdMkpp8v7D0VDgEo |
10 |
|
The document discusses the biotransformation and biodegradability of 8-2 Telomer B Alcohol (C8F17CH2CH2OH), a key raw material in the production of fluorotelomer-based products, using modified OECD 301D Closed Bottle Test to assess its degradation under aerobic conditions.
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— |
AR226-3344
|
nvX5qGxz095v9JnY2e6jLwQX |
14 |
|
The document discusses environmental fate studies of fluorotelomer intermediates, specifically 8-2 Telomer B Alcohol, conducted by DuPont, revealing its hydrolytic stability and non-toxicity to microorganisms, while also summarizing research on the degradation of fluorotelomer-based surfactants and polymers.
|
— |
AR226-3346
|
e7k6Eq83ZExrm6GNMzoa4Yb09 |
1 |
|
The document is a Good Laboratory Practice compliance statement for a one-generation reproduction study in rats conducted by E.I. du Pont de Nemours and Company, focusing on a test substance related to PFOA or PFOS, completed on October 19, 2004.
|
— |
AR226-3320
|
3QkLNrXxN6oME8wXe0679YLVO |
525 |
|
The document discusses analytical challenges in determining the presence of Telomer 8-2 Alcohol and its derived fluorosurfactants in biological and environmental matrices, highlighting method validation and recovery rates in various water types.
|
— |
AR226-3347
|
rpZLn125DoadRQkKqdG25oy2v |
18 |