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This document is a correspondence from Larry R. Zobel of 3M to Dr. Oscar Hernandez at the US EPA, providing additional documents related to studies on PFOS and PFOA that were inadvertently omitted from a previous package.
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2000 |
AR226-0612
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r4z95eqJb90Vb0y2KY60vQoe |
1 |
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This document is a correspondence from 3M's Corporate Toxicology department to the EPA, providing serum measurements for perfluorooctanesulfonate (PFOS) from two pharmacokinetic studies conducted on rats.
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2000 |
AR226-0612
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MobeQG5MvBRjBnYaOKGqa0o8z |
1 |
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3M is providing supplemental information to the EPA regarding perfluorooctane sulfonates (PFOS), including executive summaries and a summary of a 26-week toxicity study in cynomolgus monkeys, to complete their previous submission from May 4, 2000.
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2000 |
AR226-0612
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k9KO1Lj2oXaD56o3J9BxN3nJD |
1 |
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This document is a correspondence from 3M's Corporate Toxicology department confirming the submission of a non-confidential version of a toxicological study on perfluorooctane sulfonates to the EPA, following a request for information.
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2000 |
AR226-0612
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a4oGr4de671RONO0ayOmbDn0y |
1 |
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This document reports on a 26-week toxicity study of potassium perfluorooctanesulfonate (PFOS) in Cynomolgus monkeys, revealing severe health effects at the highest dose of 0.75 mg/kg/day, including illness and changes in body weight, liver function, and hormone levels, while lower doses showed no significant effects.
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2000 |
AR226-0612
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mBG7aEbg46vornRG25p3Da9Ed |
1 |
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The document reports on a developmental toxicity study of N-EtFOSE conducted on pregnant rabbits, finding that while the compound caused dose-related maternal toxicity and increased abortions at higher doses, it was not teratogenic as no malformations were observed in the fetuses.
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1999 |
AR226-0612
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575MpRO8Z36BO11LpZzdExE4 |
1 |
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The document discusses concerns regarding the finalization of a dietary toxicity study report on N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) conducted by Covance Laboratories, specifically questioning the conclusion of the no observable adverse effect level (NOAEL) being less than 3 ppm due to insufficient evidence of biological significance at that concentration.
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1999 |
AR226-0612
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XOOvZQwZbnnanJxjxDZy8J8K4 |
1 |
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Empty document.
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1998 |
AR226-0612
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zzxRz6dN8vebrkQwK1Z75JmRa |
1 |
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The document reports that a review of liver tissue sections from monkeys in a 4-week oral rangefinder study of PFOS conducted by Covance found no evidence of compound-related effects or liver necrosis, even in high dose animals.
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1998 |
AR226-0612
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82r725vOrZYm2ZjyqppbgjOGe |
1 |
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The document outlines a corporate toxicology study conducted by 3M on FC-129, focusing on its absorption, distribution, metabolism, and excretion (ADME) in rats, with the objective of identifying persistent metabolites.
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1998 |
AR226-0612
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rpmK51L22k2QmZmaLrKNr54V0 |
1 |
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The document reports on a developmental toxicity study of N-EtFOSE (N-Ethyl-Perfluoroocyanesulfonamido Ethanol) in pregnant rats, finding no teratogenic effects at any dose level, with maternal and fetal toxicity observed at doses of 10 and 20 mg/kg, and establishing a maternal and fetal toxic NOEL of 5 mg/kg.
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1998 |
AR226-0612
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6Bj0QyNeN4pqd93gGE98M9RJg |
1 |
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The document details analytical results for FM-3924, a perfluorinated compound, in corn oil samples submitted for a rat feeding study, indicating low solubility and potential crystallization issues that could affect the study's outcomes.
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1981 |
AR226-0612
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ZJ9nbomvwLjmnndRoz84QJe70 |
1 |
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The document reports on the analytical results of four corn oil samples containing varying concentrations of FM-3924, indicating that while the samples showed good reproducibility and were within 10% of target concentrations, the low solubility of FM-3924 could lead to crystallization issues that may affect a rat feeding study.
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1981 |
AR226-0612
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dYObqmgYEjBZeqrZo2jBwZLdb |
1 |
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The document compares two formulations of N-EtFOSE alcohol (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, detailing their chemical compositions and production methods.
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1980 |
AR226-0612
|
qmdRdQ4qbeJmzkJg8qaRxmpbK |
1 |
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The document compares two formulations of N-EtFOSE alcohols (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, detailing their compositions and production methods.
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1980 |
AR226-0612
|
XyyxL638GB7VrvbJMk5z0ajy |
1 |
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The document discusses a comparison of two N-EtFOSE alcohols (FM-3422 and FM-3924) used in teratology studies at Riker Laboratories, highlighting their production methods and chemical compositions.
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1980 |
AR226-0612
|
XOgoRZBwdbwD6gJJ3wjZ0E0N4 |
1 |
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The document reports the results of mutagenicity testing conducted by Riker Laboratories on various chemical samples, indicating that none of the samples tested, which may include perfluorinated compounds, showed mutagenic activity in the Ames spot test.
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1977 |
AR226-0612
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6wz6eVn1mbg54rpEEyBD3o3wm |
1 |
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This is a letter from Latham & Watkins to Dr. Charles Auer at the EPA, enclosing an analytical report from 3M's environmental monitoring program regarding perfluorinated materials.
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1973 |
AR226-0612
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Jk71z7NnGez0JLomjjRoamJB |
1 |
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Empty document.
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— |
AR226-0612
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zya00KvkQrMdKnvNyGZNQVdB |
1 |
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Unreadable document.
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— |
AR226-0612
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qVYn0zjzpG2g1RQ2pg8ORbq |
1 |
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Empty document.
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— |
AR226-0612
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pmjOnweRRdrJg08jJ0VxxrrN6 |
1 |
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Empty document.
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— |
AR226-0612
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bpkwqyBO8La5zzV1ZyXpvLN6 |
1 |
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Empty document.
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— |
AR226-0612
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k2LKRK5J3y5MmZdqYBvRdO1V |
1 |
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Empty document.
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— |
AR226-0612
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r6mmOBz0EnvN0LY4eO5oDGVGJ |
1 |
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Empty document.
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— |
AR226-0612
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EOJYNddZ7j78Ow0K5YGnB6oN |
1 |
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Empty document.
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— |
AR226-0612
|
RJQ7r12jb4KNYV4GymK5jxGnk |
1 |
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This is a notice from 3M regarding the submission of documents to the EPA related to fluorochemistry discussions, emphasizing the importance of maintaining the integrity of the original documents.
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— |
AR226-0612
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reE7zZ3Dd4x9x6z0jLOkJXY40 |
1 |
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The document discusses ongoing photodegradation testing of Perfluorooctanesulfonate (PFOS), also known as FC-95.
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— |
AR226-0612
|
n9xJYj5o8V5d54Er1e6kgE5KX |
1 |
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The document states that the boiling point of Perfluorooctanesulfonate (PFOS) is estimated to be in excess of 400°C, but no testing was conducted to confirm this.
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— |
AR226-0612
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2jDxVRYyO4xwmvx4db9anK6dg |
1 |
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The document is a Quality Assurance statement for a cell proliferation report from a 4-week toxicity study of Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) conducted on Cynomolgus monkeys, confirming compliance with Good Laboratory Practice regulations.
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— |
AR226-0612
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aJeMNEjOeQNKweqoNyDOrnRxR |
1 |
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This study investigates the mechanism of toxicity of the pesticide ethylperfluorooctane sulfonamide (NEPFOS) and its metabolite perfluorooctane sulfonamide (PFOS) on isolated rabbit renal cortical mitochondria, finding that PFOS acts as a protonophore that uncouples oxidative phosphorylation, while NEPFOS may require metabolism to PFOS for cyt
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— |
AR226-0612
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EmjpELLw4LbZ8bXrdwEKeo8ng |
1 |