|
This document consists of multiple pages marked as "DuPont Confidential," but contains no analytical content due to extensive sanitization and redaction.
|
2004 |
AR226-3324
|
KJ1z1wJJq9OaaBJajnjnm75e6 |
7 |
|
This document appears to be a summary related to the supply chain chemistry of telomers produced by DuPont for surface protection solutions, dated May 6, 2004, but contains no analytical content due to sanitization.
|
2004 |
AR226-3327
|
kmDX79408R3972pJ3N4XxoX6B |
30 |
|
The document discusses DuPont's manufacturing processes for telomer-based products, revealing the presence of trace PFOA impurities as unintended byproducts.
|
2004 |
AR226-3329
|
D6xVRwgr2XaGvMyqj4mQbmE4 |
7 |
|
The document outlines DuPont's objectives to develop a baseline understanding of the impurity profile of their Telomer products and intermediates used in manufacturing surface protection solutions, including various applications such as textiles and fire-fighting foams, while ensuring confidentiality regarding proprietary information.
|
2004 |
AR226-3328
|
MGvyX3xwMgqQJjRMb53oqDXpz |
68 |
|
The document summarizes presentations from the Society of Environmental Toxicology & Chemistry regarding DuPont's research on the biodegradation pathways and transformation products of perfluorooctyl ethanol (8-2 Telomer B Alcohol) and the soil-water partitioning of fluorotelomer intermediates used in manufacturing fluorotelomer-based polymers.
|
2004 |
AR226-3352
|
oMk9OB87N6vkrG8No9VrKb5bR |
4 |
|
The document discusses the atmospheric persistence and degradation products of fluorotelomer alcohols (FTOHs) and long-chain perfluorinated carboxylic acids (PFCAs), detailing experimental methodologies for measuring reaction rate constants involving various fluorinated compounds.
|
2004 |
AR226-3360
|
Yr8643xvD2peOzJRwq1njZeNO |
21 |
|
This manuscript reports that textiles and paper treated with a fluorotelomer-based acrylic polymer do not produce detectable amounts of perfluorooctanoic acid (PFOA) when subjected to typical municipal incineration conditions, indicating they are not a significant source of PFOA in the environment.
|
2004 |
AR226-3362
|
93Nxb4zOBqJDOooMDka9ggQxp |
58 |
|
The document summarizes presentations by DuPont at the Society of Environmental Toxicology & Chemistry North American World Congress regarding the biodegradation and environmental fate of fluorotelomer substances, specifically focusing on the biotransformation of 14C-labeled 8-2 Telomer B alcohol and its potential microbial defluorination pathways.
|
2004 |
AR226-3363
|
98Gn3w9De8wbxgOaOMoaaNjq |
3 |
|
The document reports on a 90-day subchronic toxicity study of 8-2 Telomer B Alcohol conducted by DuPont and other collaborators, revealing that while no mortality occurred, high doses led to increased liver weight, hepatic necrosis in males, and chronic nephrotoxicity in females, along with dental and plasma fluorine level changes.
|
2004 |
AR226-3392
|
vB5OZ4vamkMBnDY8Z9BYKzgJR |
1 |
|
The document presents pilot results from a toxicokinetics study on PFOA conducted by DuPont Haskell Laboratory, indicating that an oral dose of 125 mg/kg resulted in significant absorption and the identification of various metabolites in rat subjects.
|
2004 |
AR226-3394
|
jL6MOrRDg9RjBa3RvZpKEeEk |
5 |
|
DuPont submitted occupational blood monitoring summary documents to the EPA in response to a request dated November 4, 2004, regarding PFOA, asserting that the information does not trigger reporting obligations under TSCA section 8(e).
|
2004 |
AR226-3396
|
dQ75r83BEGNGZBzMVLvmRzQ1B |
16 |
|
This document appears to be a DuPont internal report discussing the fluorotelomer supply chain and its status as of December 15, 2003, but contains no analytical content due to extensive sanitization.
|
2003 |
AR226-3323
|
JNEoo19x5DEEVELr5g178qDJB |
37 |
|
The document summarizes presentations by DuPont at the SETAC Europe conference regarding the biotransformation of the fluorotelomer 8-2 Telomer B Alcohol, highlighting its potential environmental persistence and metabolic pathways for further transformation into other fluorinated species.
|
2003 |
AR226-3343
|
YrMRnk7B70LGdnor5v41yzkbD |
2 |
|
The document summarizes presentations from the Society of Environmental Toxicology & Chemistry regarding the development of analytical methodologies for determining Telomer B alcohols and Telomer-derived fluorosurfactants and polymers, focusing on challenges in analyzing these substances in environmental matrices using techniques like GC-MS and LC-MS.
|
2003 |
AR226-3348
|
xdv8GyqR4VzBNwEbJxVBkwDEJ |
2 |
|
The document discusses the physicochemical properties of fluorotelomer alcohols, specifically their vapor pressure and water solubility, which are crucial for understanding the environmental fate of these compounds, including 8-2 Telomer B alcohol used in manufacturing fluorinated surfactants and polymers.
|
2003 |
AR226-3355
|
nmaYZM38Dzkj6QEr94xObrRXa |
1 |
|
The document summarizes DuPont's environmental fate studies on fluorotelomer intermediates, specifically the Telomer B 8-2 Alcohol, highlighting its low toxicity to aerobic microorganisms and significant discrepancies in water solubility and vapor pressure compared to environmental fate models.
|
2002 |
AR226-3341
|
a1KVbMwaxqma8YbGZvGrqamXN |
1 |
|
The document is a technical report by DuPont de Nemours, Inc. detailing the aquatic toxicity and solubility of a fluorinated polymer intermediate, indicating that the maximum solubility observed was 5 mg/L with no acute toxicity detected in screening tests.
|
2001 |
AR226-3340
|
vBo7KoreqRE0L2r3O9DX20qBq |
143 |
|
The document reports on the genetic toxicology evaluation of 8-2 Telomer B Alcohol, a fluorinated chemical used in manufacturing specialty polymers and surfactants, finding no evidence of mutagenicity or toxicity in bacterial and rat tests.
|
2001 |
AR226-3389
|
e1xLj1jEKOoLyJBR9Yrj3z26M |
1 |
|
This document outlines the development and evaluation of an LC-API/MS/MS analytical method for the analysis of PFOC and PFOs in liquid surfactants, with a focus on optimizing the method specifically for PFOC while achieving good accuracy and linearity for PFOs.
|
2000 |
AR226-3335
|
KRkQ2O7X8mRXD13dNnXVY6zEx |
6 |
|
The document discusses perfluoroalkylated substances (PFAS), particularly focusing on PFOA and PFOS, their sources, environmental presence, and toxicity, highlighting their detection in humans and biota globally, with suggestions for future research.
|
2000 |
AR226-3345
|
LM9RzozLw6rRn2jvo2jLQYk7 |
1 |
|
The document discusses the ecotoxicity profile of 1H,1H,2H,2H-Perfluorodecanol (CAS No. 678-33-7), highlighting its role as a specialty intermediate in the production of Tetomer-based Polymeric Products (TBPPs) used for textile and carpet coatings, and outlines the challenges and testing strategies developed to assess its environmental
|
2000 |
AR226-3358
|
ByD5pGqdgBgVBzOd4LnrM2V4j |
1 |
|
The document evaluates the potential environmental exposure, persistence, and long-range transport potential of perfluorinated 8-2 Telomer B Alcohol (8-2 TBA) using multimedia models in the context of its industrial applications in Germany and the EU.
|
2000 |
AR226-3359
|
6wgw9Rqd8x4qnmwdpNo34aeaE |
1 |
|
The document reports that ammonium perfluorooctanoate (C-8) has been determined by DuPont to be not likely a human carcinogen or developmental toxin, based on a study involving rats that showed some liver changes and a low incidence of tumors, leading to the establishment of an acceptable exposure limit of 0.01 mg/m³.
|
1998 |
AR226-3373
|
ZBkqzdooL4096aB9Dj7MZEEbp |
4 |
|
The document establishes an Emergency Exposure Limit (EEL) of 50 ppb for C4, C6-Perfluorodiiodoalkane for emergency planning, based on studies indicating significant health effects in rats at higher exposure levels.
|
1998 |
AR226-3393
|
rByy3be1dM2yyOBGkV5pxbvdE |
2 |
|
This is a DuPont Haskell Laboratory report dated January 9, 1997, focusing on hazard characterization for human health regarding C8 exposure (CAS Registry No. 3825-26-1).
|
1997 |
AR226-3372
|
LJMy5ngKjdawkvMo9yDqvqNkq |
30 |
|
This document appears to be a laboratory report detailing the acute and chronic toxicity assessments of two fluorotelomer surfactants on algae, indicating that both compounds have EC50 values greater than 100 mg/L and a lowest NOEC of 25 mg/L for the anionic surfactant.
|
1995 |
AR226-3366
|
2mGdNVwxYdkXj3O9m6bVb5ra |
1 |
|
The document evaluates the aquatic toxicity of two perfluorinated surfactants in early life stage tests with rainbow trout, indicating they exhibit low to moderate toxicity.
|
1995 |
AR226-3367
|
JrBVB6wvm6z8aYQDqV3KmRomO |
1 |
|
The document discusses the review of pancreatic lesions in high-dose male subjects from a two-year study on FC143 (C8) conducted by 3M, noting similar incidences of acinar cell adenomas/carcinomas between the 3M and Haskell studies, while highlighting a significantly higher incidence of acinar cell hyperplasia in the Haskell study.
|
1994 |
AR226-3371
|
MJVkMnxEvxqLw6QGLpnqvy9y |
2 |
|
This document appears to be a scientific report discussing the aquatic toxicity of perfluoroalkylated substances (PFAS), detailing various test methods and species used in the assessments, along with references to standard testing guidelines.
|
1990 |
AR226-3365
|
VJ2rBj1378a4vg6zppbvRxO98 |
2 |
|
The document provides a toxicological assessment of Barium Telomer B Sulfonic Acid (Barium TBS), indicating slight acute oral toxicity and no skin or eye irritation in rabbits, while comparing its toxicity to Zonyl TBS and reporting significant respiratory effects in rats exposed to high concentrations of a Barium TBS/Teflon FEP mixture.
|
1988 |
AR226-3381
|
2Jg5pRaVvMwb8EVdxErQ3r59a |
3 |
|
The document provides a summary of the physical and toxicological properties of Ammonium Perfluorononanoate (C-9), including its moderate acute oral toxicity, recommended acceptable exposure level (AEL) of 0.01 mg/m3, and the basis for this recommendation based on comparisons to Ammonium Perfluorooctanoate (C-8).
|
1984 |
AR226-3377
|
kLXKonN6jXJKbzzdnXYg2V6J |
2 |
|
The document provides an overview of Telomer B Carbamate, including its chemical structure, physical properties, toxicity data, and recommended acceptable exposure limits (AEL) based on studies conducted by DuPont, indicating a low acute toxicity profile and a recommended AEL of 1 mg/m³ for respirable particulate.
|
1983 |
AR226-3383
|
v6pdn64eqwK7VBnkwgQw4D6dR |
2 |
|
The document outlines a study conducted by E.I. DuPont de Nemours & Co. to monitor levels of the surfactant FC-143 (ammonium perfluorooctanoate) in the workplace and environment due to potential health concerns, with objectives including measuring personnel exposure and developing accurate detection methods.
|
1981 |
AR226-3334
|
GKM50XDGzmBEzqzrj70N2Lbx4 |
29 |
|
The document provides a summary of the toxicity and human exposure studies related to Ammonium Perfluorooctanoate (C-8), also known as PFOA, highlighting its moderate acute toxicity, irritation effects, and long half-life in humans, with blood levels observed in occupationally exposed workers.
|
1981 |
AR226-3374
|
NNaqae4xXQr0jxpa7nz2bdZER |
6 |
|
This document from Haskell Laboratory provides information on Ammonium Perfluorooctanoate (C-8), detailing its physical properties, toxicity levels, and findings from clinical studies on occupationally exposed workers, indicating that PFOA has a long half-life in humans with blood levels showing only a 45% reduction over 18 months after removal from exposure.
|
1980 |
AR226-3376
|
gbe06gmypjL2xGdr2Dp49Zg3J |
6 |
|
This report details the analysis of various perfluorocarbon polymers for residues of monomers (tetrafluoroethylene and hexafluoropropylene) and the C8-emulsifier (ammonium perfluorooctanoate) used in their production, including the determination of the specific migration of the emulsifier into distilled water.
|
1979 |
AR226-3331
|
dep7Q0mMYd1QKx0qoE8KOY9Q |
11 |
|
The document discusses the concentration levels of a C-8 fluorosurfactant in a TE-3311 dispersion produced by E.I. du Pont de Nemours & Company, indicating that measurable levels were found to be between 200 ppm and 300 ppm, with an expectation of around 1200 ppm, suggesting that some of the C-8 may be trapped within the PTFE polymer.
|
1979 |
AR226-3332
|
b5z3k7z1nrwzOEoOLzJBE9axZ |
4 |
|
This document provides an overview of ammonium perfluorooctanoate (C-8), also known as PFOA, detailing its physical properties, toxicity levels, and findings from clinical studies on occupationally exposed workers, highlighting the persistence of PFOA in human blood over time.
|
1979 |
AR226-3375
|
q6e7OJOxEMMJeJ53X62XpO0q |
6 |
|
This document reports on a study conducted by E.I. DuPont de Nemours & Co. to assess worker exposure to the fluorinated surfactant FC-143, concluding that it was not detected in operator breathing zones, indicating low airborne exposure, while it was found at 0.43 ppm in process wash water.
|
1978 |
AR226-3330
|
DMONN0ZKQQe9Ok0qvymdavLoo |
32 |
|
The document provides a toxicological assessment of Telomer B Citrate Urethane (TBCU), a perfluorinated compound, detailing its physical properties, acute and subchronic toxicity findings, and establishing a recommended acceptable exposure limit (AEL) of 0.1 mg/m³ for respirable dust.
|
1976 |
AR226-3382
|
7jELd7R46jbevO9d2LJ7N2e8 |
2 |
|
This document contains work and medical histories for employees, including sample dates and C8 concentration levels, spanning various job codes and roles from 1959 to 2004.
|
— |
AR226-3477
|
mByj3KYZk0D2kYKjVew96E7o0 |
898 |
|
The document reports on a study (H-25357) conducted by DuPont to determine the approximate lethal dose (ALD) of a substance by skin absorption in rabbits, completed on August 1, 2002.
|
— |
AR226-3251
|
1Qq2yE4xvp93VjQL6wmegO7BE |
14 |
|
The document is an analytical report from DuPont Haskell Laboratory detailing the stability and purity analysis of a perfluorinated compound sample, specifically focusing on the active ingredient's concentration measured through gas chromatography.
|
— |
AR226-3252
|
QkxnN29pg9wpDv4J6mZ7nyyk5 |
5 |
|
The document details an analytical report from DuPont's Haskell Laboratory assessing the stability and active ingredient percentage of a test substance related to perfluorinated compounds, with a measured active ingredient percentage of 101.8% ± 2.9%.
|
— |
AR226-3253
|
2jQeE0rGxKLDGYDa6D9rww43a |
5 |
|
The document details an acute eye irritation study conducted by E.I. du Pont de Nemours and Company on a test substance, compliant with U.S. EPA and OECD guidelines, to assess the eye irritation potential in rabbits.
|
— |
AR226-3254
|
jNjQkbaDQVXYYJN6z658YbvMR |
18 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to determine the oral approximate lethal dose (ALD) of a substance identified as H-25357 in male rats, with doses administered ranging from 670 to 7500 mg/kg.
|
— |
AR226-3255
|
YG6YLKgE0kDejBMgn4VokzpkV |
9 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company assessing the acute toxicity of a substance coded H-25434 to the fathead minnow (Pimephales promelas) over a 96-hour period, indicating that the test substance was stable during the study.
|
— |
AR226-3257
|
B891oEqXJaBZjRgMVMn7Ywrg8 |
8 |
|
The document reports on a static, acute toxicity screening test of the substance H-25434, conducted by DuPont, which assessed its effects on Daphnia magna over a 48-hour period.
|
— |
AR226-3258
|
6BVXOxYDogJoaqp7kvbRKv1Yg |
9 |
|
The document outlines a Bacterial Reverse Mutation Test conducted by BioReliance for E. I. du Pont de Nemours and Company to assess the mutagenic potential of a test substance, with noted compliance to various GLP regulations but lacking stability analysis of the test substance.
|
— |
AR226-3256
|
0ej8OxVJgv11o7Dv08dzxkKM |
66 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to evaluate the influence of the substance H-25434 on the growth and growth rate of the green alga Selenastrum capricornutum, with testing conducted at various concentrations.
|
— |
AR226-3259
|
zb5rpkG21GmzKYNbDxJvBdQ2R |
22 |
|
The document reports on the stability analysis of the test substance H-25425, conducted by DuPont's Haskell Laboratory, utilizing high-performance liquid chromatography (HPLC) to determine its concentration and stability for protocol compliance.
|
— |
AR226-3260
|
oe8e4B4DdQbV2Vad18jb4v8N8 |
4 |
|
This is a DuPont report (number 12718) detailing a study on the water solubility of a test substance conducted under OECD guidelines, with results indicating very low solubility across various temperatures.
|
— |
AR226-3262
|
rxppRy8nzwm5zMyMxa5bk40q7 |
18 |
|
The document details a developmental toxicity study in rats (Study ID H-25231) conducted by DuPont, assessing the effects of a test substance under U.S. EPA guidelines, with compliance to Good Laboratory Practice standards, although some analyses were performed in a non-GLP laboratory.
|
— |
AR226-3261
|
4aMnNo8aJz1MLZ7q37dqv9zMp |
155 |
|
This document reports on mutagenicity test results using microorganisms, detailing the testing methods, conditions, and results, which concluded that the test substance showed no mutagenicity.
|
— |
AR226-3266
|
qkD8x1Xv91JZvwvrXOn4N0maE |
15 |
|
The document reports on the stability analysis of the test substance H-25425, conducted by DuPont's Haskell Laboratory, confirming the percentage of active ingredient through high-performance liquid chromatography (HPLC) as part of protocol requirements.
|
— |
AR226-3267
|
baqzJmg8KewBeQ2G3NgqaNpQZ |
4 |
|
The document details an analytical report from Haskell Laboratory for Toxicology and Industrial Medicine regarding the stability and concentration verification of dosing suspensions containing H-24691, a perfluorinated compound, for a repeated-dose oral toxicity study in rats.
|
— |
AR226-3268
|
QXmxz3LJjRVJJkmBBEONj34zo |
13 |
|
The document is a DuPont report detailing a study on the ultraviolet absorption spectrum of a perfluorinated compound, concluding that there is no measurable UV absorption from 225 to 400 nm.
|
— |
AR226-3269
|
6B1yrmNDqXYmg6rZXjq5pYg99 |
9 |
|
The document presents individual sperm motility data from a one-generation reproduction study in rats conducted by DuPont, focusing on the effects of exposure to a specific dosage of a perfluorinated compound.
|
— |
AR226-3264
|
kmXB9KbLdYBv3ed11rdgzVLdJ |
203 |
|
The document is a DuPont report detailing the determination of vapor pressure for a perfluorinated compound, conducted under the Telomer Research Program, with a completion date of July 16, 2002, and a report date of March 21, 2003.
|
— |
AR226-3270
|
a1rvo9ojVZQxqaBZX4onXOgeY |
11 |
|
The document outlines a one-generation reproduction study in rats conducted by E.I. du Pont de Nemours and Company, focusing on the effects of a trade secret substance related to perfluorinated compounds, with compliance to Good Laboratory Practice standards.
|
— |
AR226-3263
|
aBq570b4ggJj0qmBBKERXw5my |
255 |
|
The document is a study report by E.I. du Pont de Nemours and Company on the influence of PFOA on the growth and growth rate of the green alga Selenastrum capricornutum, conducted in compliance with Good Laboratory Practice standards.
|
— |
AR226-3271
|
ZJ5pZB4OgwG8R5Y6M4D5zvenO |
58 |
|
The document reports on a study conducted by Dr. U. Noack-Laboratorium on the effects of a water-sediment system on the development of Caenorhabditis elegans, sponsored by Asahi Glass, Clariant, Daikin Industries Ltd, and DuPont, in compliance with OECD principles of Good Laboratory Practice.
|
— |
AR226-3277
|
O112BoYBRO65zbGGjworQoMVM |
21 |
|
The document is a Good Laboratory Practice-compliant report detailing a two-week inhalation toxicity study of a test substance conducted by E.I. du Pont de Nemours and Company on male rats, with the study completed on April 2, 2003.
|
— |
AR226-3275
|
zo93XRakYkG7G1dGYqw7kw2D3 |
158 |
|
The document details an acute toxicity test conducted on earthworms (Eisenia fetida) using OECD Guideline 207, with no deviations from Good Laboratory Practice, to assess the effects of a test substance produced by Clariant, Daikin Industries Ltd, and Dupont.
|
— |
AR226-3278
|
70pL9Mwo39rgbR7eoemEYnmde |
34 |
|
This document is a study report titled "H-24743: Biopersistence Screening 10-Dose Oral Gavage Study in Rats," conducted by DuPont to evaluate the biopersistence of a substance, likely related to perfluorinated compounds, with the study completed on April 7, 2003.
|
— |
AR226-3276
|
Dd0eaZVn5yy8kqjeNKM9ozBEO |
83 |
|
This document details a subchronic toxicity study of PFOA conducted by DuPont, following U.S. EPA guidelines, which involved a 90-day oral gavage study in rats to assess the compound's health effects.
|
— |
AR226-3272
|
MJGQ1bgmbnx03bM8NL5GM6Vma |
294 |
|
The document outlines a study conducted by Dr. U. Noack-Laboratorium on the toxicity of a substance to terrestrial plants during seedling emergence, following OECD Guideline 208, with no deviations from Good Laboratory Practice reported.
|
— |
AR226-3280
|
jNQaMwbza9kjN2KrLQEd4kmaR |
52 |
|
The document outlines a developmental toxicity study conducted by DuPont on rats to evaluate the effects of a test substance, compliant with U.S. EPA guidelines, with specific notes on laboratory practices and analysis compliance.
|
— |
AR226-3279
|
71B5kRX04LaDm90oexy6OoGqg |
157 |
|
The document reports on a 90-day oral gavage study conducted by DuPont to assess the chronic toxicity of a substance, likely related to perfluorinated compounds, with specific urinalysis results for male test subjects at varying dosage levels.
|
— |
AR226-3274
|
QJ3z691y6b32pEeGQjZ9eKGDL |
347 |
|
This document reports on a study conducted by E.I. du Pont de Nemours and Company to assess the acute toxicity of the substance H-25767 to Daphnia magna, indicating that the test substance was stable and the study was completed on May 28, 2003.
|
— |
AR226-3281
|
KvYXJ5jZvZ7bO27q1wBaGDBw |
9 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, focusing on the administration of a perfluorinated compound, with specific dosage volumes recorded for each day of the study.
|
— |
AR226-3273
|
QM30ad2Op8aN4112vpQvYpZ88 |
423 |
|
The document reports on a 96-hour acute toxicity screening test of the substance H-25767, conducted by E.I. du Pont de Nemours and Company, which evaluated its effects on rainbow trout (Oncorhynchus mykiss) under static conditions.
|
— |
AR226-3283
|
pBxpB7daEKny1mdnjoGyKgEJ6 |
8 |
|
The document reports a study conducted by E.I. du Pont de Nemours and Company on the effects of the substance H-25767 (a perfluorinated compound) on the growth and growth rate of the green alga Selenastrum capricornutum, finding an EC50 of 46.0 mg/L and classifying it as harmful to aquatic organisms under TSCA.
|
— |
AR226-3284
|
7Ob9LJXYBx3LLzDJqYRaonep6 |
18 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to determine the inhalation approximate lethal concentration (ALC) of a substance identified as DuPont-12966 in rats, indicating its stability under study conditions.
|
— |
AR226-3285
|
pjraRMBL0XxowDK4M89mnGYB |
13 |
|
This document reports on a four-week inhalation toxicity study of a test substance conducted by E.I. du Pont de Nemours and Company, adhering to Good Laboratory Practice standards, to evaluate health effects in male rats.
|
— |
AR226-3282
|
YGK2pw5doM5kK3wG2ZD86NoKN |
214 |
|
The document details a subchronic toxicity study (90-day gavage) conducted by E.I. du Pont de Nemours and Company on a test substance related to PFOA, adhering to U.S. EPA Good Laboratory Practice Standards, with evaluations including one-generation reproduction assessments.
|
— |
AR226-3286
|
d6GyprzkjB2Z529y00MOarB5 |
308 |
|
This document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a test substance (likely PFOA or PFOS) over a 90-day period, including one-generation reproduction assessments.
|
— |
AR226-3288
|
Y6a8BkdaaBe9JQykOe8YmejD |
327 |
|
The document reports on a static, acute 96-hour toxicity screening test of the substance H-25914, conducted by E.I. du Pont de Nemours and Company, which evaluated its effects on the rainbow trout, Oncorhynchus mykiss.
|
— |
AR226-3291
|
zoYRj0jM43dDMO0q5MRY4QOEg |
9 |
|
The document reports on a static, acute 48-hour toxicity screening test conducted by DuPont on the substance H-25914, assessing its effects on Daphnia magna, with findings indicating the test substance was stable and did not exhibit toxicity at the tested concentrations.
|
— |
AR226-3292
|
O1r1xRg1L867y6Oz1R4e2jkwL |
9 |
|
The document reports on a subchronic toxicity study of PFOA conducted by DuPont, detailing the microscopic observations and incidences of non-neoplastic lesions in male rats after 90 days of gavage treatment.
|
— |
AR226-3287
|
ev6JNQwdKgYaqBm10NZGyD1Eq |
436 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a perfluorinated compound over 90 days, including individual animal observations and histopathological findings.
|
— |
AR226-3289
|
3Qb2xZdZeKaKknLEzwjdv7aMy |
348 |
|
The document is a study report by E.I. du Pont de Nemours and Company detailing a 28-day repeated dose dermal toxicity study in male rats, conducted under U.S. EPA and OECD guidelines, to evaluate the effects of a test substance characterized as a trade secret.
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— |
AR226-3293
|
np4R7KbYOvOnpx5B8Qng8gw5w |
204 |
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The document details a subchronic toxicity study conducted by DuPont on male rats, evaluating the effects of a 90-day gavage exposure to a substance, likely related to PFOA or PFOS, with specific focus on sperm and spermatid counts.
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AR226-3290
|
7OvgneD6YGGyZX0Rd6oeJgb68 |
362 |
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The document reports on a study conducted by E.I. du Pont de Nemours and Company to assess the influence of the substance H-25914 on the growth and growth rate of the green alga Selenastrum capricornutum, revealing effects at various concentrations over a 72-hour exposure period.
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AR226-3294
|
1qEXgpoZQx8aEBOo0Kqzn40Z |
20 |
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The document details a biocompatibility study (H-25878) conducted by North American Science Associates, Inc. for E.I. du Pont de Nemours and Company, focusing on the cytotoxicity of a substance related to PFOA/PFOS, with the study completed on August 26, 2003.
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AR226-3295
|
Yj4mEgNMb87DVXOGNevOz1Gbk |
30 |
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This document is a report on a 90-day subchronic toxicity study of PFOA conducted by DuPont on male rats, authored by Linda A. Malley, Ph.D., and completed on September 4, 2003.
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— |
AR226-3297
|
rBpX2xJ1ZrMyYv7eBYaMvb5Z0 |
50 |
|
The document reports on a 28-day repeated-dose dermal toxicity study of a substance conducted by E.I. du Pont de Nemours and Company, focusing on male rats, in compliance with U.S. EPA and OECD guidelines.
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— |
AR226-3296
|
ppzZoYYVK1K2ddb7XyMyjxmQw |
158 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company, led by Dr. Michael P. DeLorme, to determine the inhalation approximate lethal concentration (ALC) of a substance identified as DuPont-13308 in rats, completed on September 9, 2003.
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— |
AR226-3299
|
dYBpnz6ba3R4Q46nn7b9xNodq |
12 |
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The document reports on a study commissioned by DuPont KK to evaluate the accumulation of a perfluorinated compound in carp, conducted by the Chemicals Evaluation and Research Institute in Japan, with preliminary tests indicating acute toxicity.
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— |
AR226-3300
|
J30vKx7MojzRz482V5rGo4JJ2 |
19 |
|
The document is a study report by E.I. du Pont de Nemours and Company on the early life-stage toxicity of a test substance to rainbow trout (Oncorhynchus mykiss), conducted in compliance with U.S. EPA Good Laboratory Practice Standards.
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— |
AR226-3298
|
LpkYNma5JzNQLZjqY1pyeMkQQ |
138 |
|
This document is a study report commissioned by DuPont KK analyzing impurities in a non-GLP study context, specifically related to perfluorinated compounds.
|
— |
AR226-3301
|
KG12N20ZgQkB2QLGRYg2x1OKr |
9 |
|
This is a study report from the Chemicals Evaluation and Research Institute in Japan (Study No. 33620) commissioned by DuPont KK, analyzing the residual solvent ethanol in Forafac 1157 using gas chromatography, with results indicating 0% ethanol content.
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— |
AR226-3302
|
1y9w1GYeGnOB6dGE7roVw5YX |
12 |
|
The document is a study report from the Chemicals Evaluation and Research Institute in Japan, detailing a non-GLP study on the biodegradation of perfluorinated compounds by microorganisms, specifically focusing on the methodology and results related to the test substances involved.
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— |
AR226-3303
|
91xwaGjRQdrg2g87aBVBEjpXe |
23 |
|
The document reports on the stability analysis of the test substance H-24921, a perfluorinated compound, conducted by DuPont's Haskell Laboratory, confirming the active ingredient's purity within the expected range based on high-performance liquid chromatography/tandem mass spectrometry methods.
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— |
AR226-3304
|
La9K6zZm6YxMvJqr0MkvV4Vd |
5 |
|
The document details the stability analysis of the test substance H-24921, a perfluorinated compound produced by DuPont, using high-performance liquid chromatography/tandem mass spectrometry, with results indicating nominal concentrations for further studies.
|
— |
AR226-3305
|
ExwJBJd5mgx1jY3zLqawO0e2N |
5 |
|
The document details a study conducted by E.I. du Pont de Nemours and Company on the influence of a test substance on the growth and growth rate of the green alga Selenastrum capricornutum, adhering to OECD and EPA guidelines.
|
— |
AR226-3306
|
npx6e4nEnkd1QpxpmQyRJ0kn8 |
60 |
|
This document presents the results of a chromosomal aberration test using mammalian culture cells, specifically detailing the conditions and materials used in the study, but does not mention PFOA or PFOS.
|
— |
AR226-3307
|
KR555nnjXwZE9pawJ5wn3d2Dr |
21 |
|
The document outlines a study conducted by E.I. du Pont de Nemours and Company on a perfluorinated compound, adhering to Good Laboratory Practice Standards, with a focus on the characterization of the test substance, which included an analysis of its percent content of PFOA.
|
— |
AR226-3308
|
Ran8KGg9RNZDqVnwmkB34oOOE |
35 |
|
The document is a final report on an in vitro mammalian chromosome aberration study conducted by BioReliance for E. I. duPont de Nemours and Company, focusing on the effects of a test substance, likely related to PFOA or PFOS, on human peripheral blood lymphocytes, with compliance to Good Laboratory Practice standards noted.
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— |
AR226-3309
|
peZRj6mo9bGEvap7VzJm1MyrB |
40 |
|
This document is a study report from DuPont titled "Biopersistence Screening 10-Dose Oral Gavage Study in Rats," which evaluates the biopersistence of a substance, likely related to PFOA or PFOS, completed on November 26, 2003.
|
— |
AR226-3310
|
qw30p61eB1kz3ybEBqoZgOrE |
82 |