|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a test substance (not specified) at a dosage of 1000 mg/kg/day, which resulted in minimal liver inflammation and mild alterations in the thyroid gland.
|
1998 |
AR226-3187
|
qajyVzzowgV9Oa15MKxp2ayeR |
260 |
|
The document reports on a subchronic toxicity study conducted by DuPont, evaluating the effects of a 90-day gavage of a test substance on rats, including grip strength assessments, as part of reproductive evaluations.
|
1998 |
AR226-3186
|
oMoRNQjmBEkqgywZo2v6E4em3 |
331 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a 90-day gavage exposure to a perfluorinated compound, with a focus on body and organ weights, as part of reproductive evaluations.
|
1998 |
AR226-3188
|
0gB0JXbqp2O05p1w5ZRJZ00Nm |
341 |
|
This document reports on a subchronic toxicity 90-day gavage study in rats evaluating one-generation reproduction effects of a test substance conducted by E.I. du Pont de Nemours and Company, adhering to U.S. EPA guidelines.
|
1998 |
AR226-3197
|
Lpk7385J7vV0DxM8w9XJozmOw |
316 |
|
The document reports on a 90-day subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a specific dosage of a perfluorinated compound, including body and organ weights, as part of one-generation reproductive assessments.
|
1998 |
AR226-3201
|
Yrpw5aXeZ18OvxDjbBnavrm6O |
220 |
|
The document reports on a 90-day subchronic toxicity study of an unspecified substance conducted by DuPont, detailing microscopic observations of liver lesions in male rats, including necrosis and inflammation at various dosage levels.
|
1998 |
AR226-3198
|
aQ4Yz5KDog6BnqJG9Ng4r7DR |
333 |
|
The document details a 90-day gavage study on rats conducted by DuPont to evaluate the subchronic toxicity and one-generation reproductive effects of a perfluorinated compound, with clinical and ophthalmological observations recorded throughout the study.
|
1998 |
AR226-3199
|
b5j4LNyQmd8xG38K1beZjrKV6 |
367 |
|
The document reports on an acute eye irritation study conducted by Elf Atochem S.A. using a test substance, with results evaluated in rabbits to assess ocular reactions and classify the irritancy of the substance.
|
1997 |
AR226-3067
|
qaBrXD12vVQ1jDb4nzOKp8ndR |
20 |
|
The document is a study report from Elf Atochem S.A. detailing an acute dermal irritation test conducted on rabbits using a test substance, with the study completed on February 3, 1997, at the Centre International de Toxicologie, which evaluates the irritant potential of the substance according to established guidelines.
|
1997 |
AR226-3068
|
by27Zbrg5O16NnnMG42bqvby6 |
19 |
|
The document reports the results of USP biocompatibility testing for H-22239 (control item) and H-22240 (test item) conducted by North American Science Associates, Inc. for E. I. du Pont de Nemours and Company, indicating that both substances were non-toxic and passed the tests.
|
1997 |
AR226-3066
|
oeXE48aedZ9j1KGLqQogvNML8 |
33 |
|
The document reports on a static acute 96-hour screening test of the substance H-22274, conducted by Haskell Laboratory for Toxicology and Industrial Medicine, which found that H-22274 exhibited low toxicity to fathead minnows (Pimephales promelas) at various tested concentrations.
|
1997 |
AR226-3070
|
g29MnK8xovE05doZG4v27mnzN |
2 |
|
The document reports on an acute oral toxicity study of a test substance conducted by Elf Atochem S.A. in rats, completed on February 5, 1997, at the Centre International de Toxicologie, detailing clinical examinations, body weight changes, and necropsy results.
|
1997 |
AR226-3069
|
3V685N6Lx3ZDmeYmz85Ro4VJ |
23 |
|
This document reports on a static acute 48-hour toxicity test of the substance H-22274, conducted by DuPont, which concluded that H-22274 exhibited low toxicity in aquatic environments.
|
1997 |
AR226-3071
|
6BLeo3p7ydjMGmxXoDj44303o |
2 |
|
The document reports on an inhalation toxicity screen conducted by DuPont on a test substance, revealing that all rats exposed to the aerosolized compound died within four days, with clinical signs of irregular respiration and lethargy observed.
|
1997 |
AR226-3074
|
QkeoQyX4j3z3oxGqQ5O35o5j5 |
2 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to determine the inhalation approximate lethal concentration (ALC) of a test substance identified as H-22359 in rats, completed on June 17, 1997, while noting a deviation from Good Laboratory Practice standards that did not affect the study's integrity.
|
1997 |
AR226-3073
|
zdB8prjkJb3DBp3n0RX2nvDQ6 |
12 |
|
The document reports on an inhalation toxicity study conducted by E. I. du Pont de Nemours and Company, which found that exposure to H-22485 resulted in severe health effects, including mortality and clinical signs of toxicity in rats.
|
1997 |
AR226-3075
|
9w3GdgpqRq1NqkBvywEYnaDe |
2 |
|
The document is a final report from DuPont's Haskell Laboratory detailing a study on the incorporation assay of E. coli, conducted under Good Laboratory Practice standards, but notes exceptions regarding the determination of stability and composition of test substances.
|
1997 |
AR226-3072
|
MoE34jrpyzd2KnrVJwdbJ0mYM |
54 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on a test substance (identified as DuPont HL-1997-00716) applied to rabbits, which showed no evidence of edema or significant dermal effects after a 4-hour exposure.
|
1997 |
AR226-3076
|
RJ3Yz3pxNGaNJ2NeJ5Kppj7Rn |
8 |
|
The document reports on an eye irritation test conducted by DuPont on a substance identified as H-22762, which resulted in moderate conjunctival redness and slight conjunctival chemosis in rabbits, indicating some irritation potential.
|
1997 |
AR226-3077
|
jmxJQd6GygqRZDy15xRY1n8B9 |
9 |
|
The document details a mutagenicity study conducted by DuPont on a test substance using the Salmonella typhimurium Plate Incorporation Assay, indicating that the substance appeared stable during the study.
|
1997 |
AR226-3078
|
ZJxgbaD4bRZBxZOvw3jdDba6p |
16 |
|
The document reports on a study conducted by DuPont to determine the inhalation approximate lethal concentration (ALC) of a perfluorinated compound in rats, indicating that the test substance was stable and the study involved exposure to aerosolized concentrations measured by gravimetric filter analysis.
|
1997 |
AR226-3079
|
7OMDq3R0gwYBMvEnxZNDpYN2R |
11 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company which determined that the oral approximate lethal dose (ALD) of a substance identified as H-22762 in male rats is 5000 mg/kg, indicating it is slightly toxic.
|
1997 |
AR226-3081
|
4JwZzEEQgZMw374ZeoggXvb8p |
7 |
|
The document reports on a skin irritation test conducted by E.I. du Pont de Nemours and Company on a test substance involving 6 female New Zealand White rabbits, which assessed the acute skin irritation potential after a 4-hour exposure.
|
1997 |
AR226-3082
|
VJVVvpQpgDZpvkLbLGdBKEDEw |
10 |
|
The document reports on a toxicity study of a DuPont chemical (H-22387) conducted by T.R. Wilbury Laboratories on the freshwater alga, Selenastrum capricornutum, in compliance with EPA and OECD guidelines, initiated on May 2, 1997, and completed on September 17, 1997.
|
1997 |
AR226-3080
|
Zn34XyMrqj8yMqYE65VOZNJLL |
41 |
|
The document reports on an eye irritation test conducted by DuPont on a test substance, assessing its acute eye irritation potential in rabbits, with the study completed on December 19, 1997.
|
1997 |
AR226-3083
|
0g4e1y3j20bw8V3qJak8rOzrm |
10 |
|
The document details a study conducted by DuPont on the oral approximate lethal dose (ALD) of a test substance in male rats, completed on December 30, 1997, as part of their toxicology research.
|
1997 |
AR226-3084
|
dMDZy69ZwEy9GEKmR5JMXQX6 |
8 |
|
The document reports on a skin irritation test conducted by DuPont on a test substance (H-23004) involving the application of the substance to the skin of rabbits, with observations made at various time intervals post-exposure.
|
1997 |
AR226-3085
|
10147p2j0L948B64wwrpQdXEo |
10 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company to determine the approximate lethal dose (ALD) of the substance H-21333 in rats, completed on January 23, 1996, while noting deviations from Good Laboratory Practice standards that did not affect the study's validity.
|
1996 |
AR226-3036
|
RaNr4V7N9xqLv13JaojGjNDnn |
8 |
|
The document reports on an eye irritation test of the substance H-21460, conducted by E. I. du Pont de Nemours and Company, which found that H-21460 caused moderate eye irritation in rabbits, with symptoms resolving within a few days.
|
1996 |
AR226-3037
|
G5Xqwaan3rV41g1kB7KN4kzex |
11 |
|
The document reports on a skin irritation test of the substance H-21460, conducted by E. I. du Pont de Nemours and Company, which found it to be a mild skin irritant in rabbits, with irritation clearing by 48 hours post-application.
|
1996 |
AR226-3038
|
baqVrMrpGp68pax0bx6D5Jg6o |
10 |
|
The document reports that the approximate lethal dose (ALD) of the substance H-21460, tested by E. I. du Pont de Nemours and Company on male rats, was found to be greater than 11,000 mg/kg, indicating very low toxicity.
|
1996 |
AR226-3039
|
3eKogvwGG3KpZ8R4n4ZY5EaBO |
7 |
|
The document reports a skin irritation test of DuPont's H-21665 on rabbits, revealing that the substance caused mild to moderate erythema and edema, with desquamation observed at 72 hours post-exposure.
|
1996 |
AR226-3041
|
KRgO0EQg5jk3gBvLy4vMKb8p2 |
9 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21987, which was found to be a mild skin irritant in rabbits, with varying degrees of erythema observed.
|
1996 |
AR226-3042
|
YGVQMDNvwa9MpK64LBMxkLrE0 |
10 |
|
The document reports on an eye irritation test conducted by E. I. du Pont de Nemours and Company, which found that the substance H-21987 caused moderate eye irritation in rabbits, with symptoms resolving within one to three days depending on whether the eye was washed after treatment.
|
1996 |
AR226-3043
|
nkgk8zbOZw5xXXepx6N7V40Rm |
12 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21951, which was found to be a mild skin irritant in rabbits, showing slight erythema at 1 and 24 hours post-exposure but clearing by 72 hours.
|
1996 |
AR226-3044
|
JvdRR1xv1kRrogdqKGLwprQr2 |
10 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the acute eye irritation potential of the substance H-219S3 in rabbits, which resulted in moderate conjunctival redness and iritis, but no long-term toxicity, with both treated eyes returning to normal by day three post-treatment.
|
1996 |
AR226-3045
|
50DNN8o6Dm0xqMXvXvvZLVNa4 |
12 |
|
The document reports on a skin irritation test of the substance H-21953, conducted by E. I. du Pont de Nemours and Company, which showed that the substance caused slight or mild erythema in rabbits at 1 and 24 hours post-exposure.
|
1996 |
AR226-3046
|
DZ1d2g2zGMJ3y9rmMm1QgYLn |
10 |
|
The document reports on an eye irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21951, which resulted in moderate conjunctival redness and slight chemosis in rabbits after instillation.
|
1996 |
AR226-3047
|
YDKnQL88yX52rp6qq5kjqr3R8 |
12 |
|
The document reports on a study conducted by DuPont to determine the approximate lethal dose (ALD) of the substance H-21951 in rats, finding that no deaths occurred at doses greater than 11,000 mg/kg.
|
1996 |
AR226-3048
|
0gamG1vdZDRXXrb964M39QgGd |
8 |
|
The document reports on a study conducted by DuPont assessing the approximate lethal dose (ALD) of the substance H-21953 in male rats, finding it to be greater than 11,000 mg/kg, indicating very low toxicity.
|
1996 |
AR226-3049
|
2RQxpo06qvjQzjkYg55QQOy8p |
8 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21946, which showed slight or mild erythema but no edema in rabbits after a 4-hour exposure.
|
1996 |
AR226-3050
|
RxDj8j9q5y7xZemXRrbBZyQV |
10 |
|
The document reports on a Local Lymph Node Assay conducted by DuPont using the test substance H21951, which showed no sensitization effects in female CBA/JHsd mice at various concentrations, while a positive control with hexylcinnamaldehyde demonstrated a sensitization response.
|
1996 |
AR226-3052
|
2Rd2ybpy640oB61MzJw3KEdBL |
1 |
|
The document reports on an eye irritation test conducted by DuPont on the substance H-21946, which resulted in mild to moderate conjunctival redness and slight chemosis in rabbits, indicating its potential irritative effects.
|
1996 |
AR226-3051
|
jKkKDqYvY8eLZdnO05d7vO3Q |
12 |
|
The document reports on a Local Lymph Node Assay (LLNA) conducted by DuPont to evaluate the sensitization potential of a test substance (H21953) in female mice, concluding that H21953 was not a sensitizer while hexylcinnamaldehyde (HCA) produced a positive sensitization response.
|
1996 |
AR226-3053
|
XxoJyDvwQMy79Ed7dBXN8E6w |
1 |
|
The document reports on a Local Lymph Node Assay (LLNA) conducted by DuPont to evaluate the sensitization potential of the substance H22051 in female CBA/JHsd mice, concluding that H22051 is not a sensitizer, as all stimulation indexes were below 3.0 and no dose response was observed.
|
1996 |
AR226-3054
|
qkpzjopO258BV4Oa6Gx1OKyBR |
1 |
|
The document reports that the substance H-21987, tested by E. I. du Pont de Nemours and Company, showed an approximate lethal dose greater than 11,000 mg/kg in male rats, indicating very low toxicity when administered as a single oral dose.
|
1996 |
AR226-3056
|
QJNJyDeRad32qmOOYZyOwErY5 |
8 |
|
The document reports on a 100-person human patch test conducted by ConTox Limited for E. I. du Pont de Nemours and Company, which found that the substance H-22056, associated with PFOA, did not cause skin irritation or sensitization in participants.
|
1996 |
AR226-3057
|
xzROmbk2zxjrMVqaM94D3LwQy |
19 |
|
The document reports on a 100-person human patch test conducted by ConTox Limited for DuPont, which found that the test item H-22055 did not cause skin irritation or sensitization in participants.
|
1996 |
AR226-3058
|
Xw3kEoa278Kr1D3g373RbXaG |
19 |
|
The document reports on a 100-person human patch test conducted by ConTox Limited for E. I. du Pont de Nemours and Company, which concluded that H-22033, a test item, did not cause skin irritation or hypersensitivity in participants.
|
1996 |
AR226-3059
|
ndx1azmMZMRz5Kk3MOxRNR9z |
19 |
|
The document reports on a 100-person human patch test conducted by ConTox Limited for E. I. du Pont de Nemours and Company, which found that the test item H-21936 did not cause skin irritation or sensitization in participants.
|
1996 |
AR226-3060
|
EdzQNN48jkBzz36Yre3qzJYBV |
19 |
|
The document reports the biocompatibility testing results for DuPont's substances H-22072, H-22073, and H-22074, indicating that all samples passed cytotoxicity and intracutaneous tests, confirming their non-toxic status.
|
1996 |
AR226-3061
|
dYa65QX2KprDvdJ4xg3kEm34B |
53 |
|
The document reports that a study conducted by E. I. du Pont de Nemours and Company found that the approximate lethal dose (ALD) of the substance H-21095 in male rats was greater than 11,000 mg/kg, indicating very low toxicity when administered as a single oral dose.
|
1995 |
AR226-3015
|
06GGdy6qZw0zx1wYob6Vw4GzM |
6 |
|
The document reports on a reverse mutation assay conducted by Elf Atochem S.A. to assess the mutagenicity of a test substance using Salmonella typhimurium, with the study completed on March 24, 1995, at the Centre International de Toxicologie in France.
|
1995 |
AR226-3012
|
6RZmykakRqR4D4dmvOxkZ53x6 |
20 |
|
The document reports the results of USP biocompatibility testing for the substances H-21016 and H-21017, conducted by North American Science Associates, Inc. for E. I. du Pont de Nemours and Company, indicating that both substances passed various toxicity tests.
|
1995 |
AR226-3014
|
xj4Xw0xj6RMzzejkvrRmLv1ZE |
11 |
|
The document reports on an eye irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21095, which was found to be a mild, transient eye irritant in rabbits.
|
1995 |
AR226-3016
|
grMdEDXOE9Bdvn5wazOEV32G |
10 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-21095, which showed moderate skin irritation potential in rabbits, with slight to moderate erythema observed shortly after application but no clinical signs of toxicity.
|
1995 |
AR226-3017
|
9kQdqgEp4Op19jXadmLQzjmR |
8 |
|
The document reports on a skin sensitization test conducted by Elf Atochem S.A. using guinea pigs to evaluate the allergenic potential of a test substance, with the study completed on March 24, 1995.
|
1995 |
AR226-3013
|
qdYBbyxKa9me0EwajQ5M0rmQk |
29 |
|
The document reports on a 14-day feeding study conducted by E. I. du Pont de Nemours and Company to evaluate the repeated dose oral toxicity of H-19683 in male mice, finding significant decreases in body weight and increases in liver weights at the highest dose of 3000 ppm.
|
1995 |
AR226-3018
|
r2QJYRzvz42Jpp5ZV9R81Drv |
23 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the acute eye irritation potential of the substance H-21209 in rabbits, finding it to be a mild eye irritant.
|
1995 |
AR226-3024
|
rBOpbzvmRevMxvMywwR2zmgjV |
10 |
|
The document reports a study conducted by E. I. du Pont de Nemours and Company to determine the approximate lethal dose (ALD) of the substance H-21209 in male rats, finding it to be greater than 11,000 mg/kg, indicating very low toxicity.
|
1995 |
AR226-3026
|
gbJjvELRoZXLpy16K30j4yyDL |
5 |
|
The document reports on a 100-person human patch test conducted by Biosearch, Inc. for E. I. du Pont de Nemours and Company to evaluate the potential irritation and delayed hypersensitivity of three test materials, including H-21273 and H-21274, with findings indicating their stability during the study.
|
1995 |
AR226-3023
|
2JJge4jxLk6m92d4Vag755Oq6 |
32 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company, which found that the substance H-21209 exhibited mild skin irritation in rabbits, with slight erythema and no edema observed after exposure.
|
1995 |
AR226-3027
|
XR45rj6zV43J6dRqKorZ4Y91y |
8 |
|
The document reports on a study conducted by E. I. du Pont de Nemours and Company evaluating the skin corrosion potential of the substance H-21333 using the In Vitro CorrositexTM assay, which determined it to be corrosive and assigned it to Packing Group III.
|
1995 |
AR226-3031
|
qaE9Zbg6rwryVBvDOgZ3OmGOE |
4 |
|
The document reports on a gene mutation assay conducted in vitro using Chinese hamster V79 cells, as part of CCR Project 509800, confirming compliance with Good Laboratory Practice standards, but does not specify findings related to PFOA or PFOS.
|
1995 |
AR226-3029
|
0J3RaOB694jo0eYp9ygG9bVMR |
29 |
|
The document is a test report certifying that the mutagenicity assay for PFOA conducted in Chinese hamster V79 cells by CCR Cytotest Cell Research GmbH was completed in compliance with Good Laboratory Practice principles.
|
1995 |
AR226-3030
|
8R2YQZzwbDmxwyeZdZOn91bxa |
29 |
|
The document describes an in vitro chromosome aberration study conducted by BioReliance for DuPont, focusing on human peripheral blood lymphocytes, and outlines compliance with various regulatory guidelines while noting exceptions regarding the characterization and stability of test articles.
|
1995 |
AR226-3181
|
EvvQR5EkqqgKvvBK6M7GqXgXj |
40 |
|
The document outlines a bacterial reverse mutation test (Study No. H-24889) conducted by BioReliance for DuPont, assessing the genotoxicity of a test article under compliance with various regulatory guidelines, although it notes exceptions regarding the determination of control article characteristics and stability.
|
1995 |
AR226-3180
|
LgjgZQk20GppKvyGwpJ2G9rab |
63 |
|
The document is a laboratory report from Haskell Laboratory, authored by John V. Sarver, indicating that the substance H-203M, produced by E. I. du Pont de Nemours and Company, was found to be a slight skin irritant in an acute irritation study conducted on rabbits.
|
1994 |
AR226-3001
|
B5j5NQRw4bLbe7MZqG04N3kvL |
8 |
|
The document reports on a skin irritation test conducted by E. I. du Pont de Nemours and Company on the substance H-20431, which resulted in severe erythema and moderate edema in rabbits, indicating significant skin irritation potential.
|
1994 |
AR226-3002
|
yrMYRBwxmJ27rQyjmxQ3Om7p3 |
9 |
|
The document reports a study conducted by DuPont to determine the approximate lethal dose (ALD) of the substance H-20431 in male rats, finding that the ALD is greater than 11,000 mg/kg, indicating very low toxicity.
|
1994 |
AR226-3003
|
YrGkY4m84eEvp7z3bmD9DMVZV |
7 |
|
The document is a report by DuPont detailing a study on the acute toxicity of the test substance H-19518, a perfluorinated compound, conducted in accordance with OECD guidelines.
|
1994 |
AR226-3005
|
YDn8z9a9QMQ1wnL2keyD140zy |
15 |
|
The document is a subchronic inhalation toxicity study report conducted by E. I. du Pont de Nemours and Company on a test substance, likely related to PFOA or PFOS, which was completed on December 21, 1994, and noted a deviation in compliance with Good Laboratory Practice standards regarding the characterization of the test substance.
|
1994 |
AR226-3007
|
aXawoYpXvpG1Jqyo1d4J9aER |
157 |
|
The document details an acute oral toxicity study (DuPont-6711) conducted by E. I. du Pont de Nemours and Company on a perfluorinated compound, adhering to OECD guidelines and U.S. EPA Good Laboratory Practice standards, with findings indicating sufficient data accuracy despite certain procedural limitations.
|
1992 |
AR226-3182
|
peDwzD256kj35Qj1VQONJGNNX |
27 |
|
The document reports on an acute dermal irritation/corrosion study conducted by E.I. du Pont de Nemours and Company on a substance identified as DuPont-8778, following OECD guidelines, with the study completed on December 10, 2001.
|
1992 |
AR226-3202
|
2RNO30OxxQDMnx8aX84e6OLVL |
15 |
|
This is a DuPont report (Project ID: DuPont-9104) detailing an acute eye irritation/corrosion study conducted on rabbits, completed on January 3, 2002, in accordance with OECD guidelines.
|
1987 |
AR226-3213
|
Ego8ezKmo1vkm306nyLVQYGR |
16 |
|
The document reports on a skin irritation test conducted by DuPont in 1999 using two substances, H-23746 and H-23747, on male New Zealand White rabbits to evaluate their acute skin irritation potential.
|
1977 |
AR226-3111
|
7O0bO0EJMaz6GZrN1y17NZ0QE |
12 |
|
The document reports on a subchronic toxicity study conducted by DuPont on female rats, evaluating the effects of a 90-day gavage exposure to a substance (likely PFOA or PFOS) with findings of various liver lesions at different dosage levels.
|
— |
AR226-3220
|
dQ3xkN8gopJqaxJQO5NbgGBBB |
275 |
|
This document is a supplement to a biopersistence screening study on PFOA conducted by DuPont, detailing the methodology and findings from a 10-dose oral gavage study in rats, completed on August 29, 2000.
|
— |
AR226-3227
|
KGKpBL49ZpwJV7EN0pXwaVOoX |
41 |
|
This is a final report from Covance Laboratories (Study 22900-0-4090ECD) detailing a mammalian microsome reverse mutation assay conducted between October 2001 and February 2002.
|
— |
AR226-3228
|
Dvq0wNkVOVNm8K6Mp8mOYMZYn |
39 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a test substance (likely PFOA or PFOS) over 90 days, with findings indicating no significant macroscopic abnormalities in various organs and minimal biliary hyperplasia in the liver.
|
— |
AR226-3222
|
rpk0D2GXZrXqgyRyxEgDX9z87 |
280 |
|
The document is a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a 90-day gavage exposure to a substance (likely PFOA or PFOS) with one-generation reproductive assessments included.
|
— |
AR226-3221
|
rjLk1NDkemd864zyavD8yde |
329 |
|
The document is a compliance statement for a bacterial reverse mutation test conducted by BioReliance for E. I. du Pont de Nemours and Company, indicating that the study did not determine the identity, strength, purity, or stability of the test substances, which are related to PFOA/PFOS.
|
— |
AR226-3229
|
gEyakK5nk8axngV8p46LegGJ |
64 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company assessing the effects of the substance H-24616 on the growth of the green alga Selenastrum capricornutum, finding an estimated EC50 of 870 mg/L and indicating low concern under TSCA.
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AR226-3231
|
gDqEEOjbxoav8epwggORLapbe |
16 |
|
The document is a compliance statement for a Bacterial Reverse Mutation Test (Study No. H-25171) conducted by BioReliance for E. I. du Pont de Nemours and Company, indicating that the study adhered to various GLP regulations but lacked certain analyses on the test and control articles.
|
— |
AR226-3230
|
zN5m0vjJ3rVoOgMN5r3K0J20 |
63 |
|
This document details a subchronic toxicity study conducted by E.I. du Pont de Nemours and Company on PFOA in rats, evaluating both toxicity and one-generation reproduction effects, completed in compliance with U.S. EPA Good Laboratory Practice standards.
|
— |
AR226-3219
|
L5KGm5dLq6JovQ2M1bgJNXBq |
337 |
|
The document details a bacterial reverse mutation test (Study No. H-24890) conducted by BioReliance for E. I. du Pont de Nemours and Company, indicating compliance with various GLP regulations but noting that the identity, stability, and concentration of the test substance, which is unspecified, were not determined.
|
— |
AR226-3233
|
gEL5NObw44Z92y7m8dwjJXzGG |
65 |
|
The document outlines a developmental toxicity study (H-24768) conducted by E.I. du Pont de Nemours and Company on rats to evaluate the effects of a test substance, likely related to PFOA or PFOS, in compliance with U.S. EPA and OECD guidelines.
|
— |
AR226-3232
|
xjenLOrRYdV2wx69JkDq92Vd0 |
166 |
|
The document outlines a subchronic toxicity 90-day gavage study in rats conducted by E.I. du Pont de Nemours and Company, evaluating the effects of a test substance, likely related to perfluorinated compounds, under U.S. EPA guidelines.
|
— |
AR226-3234
|
2YRGOVaqDOy9xoqDD2Ge74eb |
317 |
|
The document reports on a subchronic toxicity study of DuPont's chemical (identified as DuPont-5386) conducted on rats, revealing minimal inflammation in the liver, chronic progressive nephropathy in the kidneys, and minimal colloid alteration in the thyroid gland.
|
— |
AR226-3237
|
bB7DeoZygkpkndVRbKekLnZa3 |
312 |
|
The document is a revised report of a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a 90-day gavage exposure to a substance, likely PFOA or PFOS, with a focus on body and organ weights, including thyroid gland measurements.
|
— |
AR226-3238
|
LKkz5Krnvw8YGjZ2oj369GzQX |
228 |
|
The document reports on a subchronic toxicity study conducted by E.I. du Pont de Nemours and Company, evaluating the effects of a substance (likely PFOA or PFOS) on male rats over a 90-day period, highlighting findings of liver lesions including necrosis and inflammation.
|
— |
AR226-3235
|
RpyKeqQ6r61GYejxJ5J8E7r8E |
392 |
|
The document details a subchronic toxicity study conducted by DuPont on rats, evaluating the effects of a perfluorinated compound over a 90-day period, including one-generation reproduction assessments and clinical observations.
|
— |
AR226-3236
|
gadk0N4eaZdOVGGgEEbNgeMrq |
375 |
|
The document reports on a study conducted by E.I. du Pont de Nemours and Company to determine the inhalation approximate lethal concentration (ALC) of a substance coded H-24678 in rats, indicating that the test substance was stable under study conditions.
|
— |
AR226-3239
|
em3ooLGwg4mNxkDwYaJ8a055y |
15 |
|
The document is a report on a dermal sensitization test using the Buehler method conducted by DuPont on a substance identified as DuPont-9303, with the study completed on April 5, 2002.
|
— |
AR226-3240
|
NNkpwvr7oBE5X4NowmzOJoYR8 |
26 |
|
The document reports on a mixing and stability study for H-24691, a perfluorinated compound, in preparation for a repeated-dose oral toxicity study in rats, detailing the concentrations tested and the methods used for verification and stability analysis.
|
— |
AR226-3241
|
gzg3906bqOLzbpXYvxwobE89 |
13 |
|
The document reports on the Corrositex In Vitro Test (Study H-25240) conducted by DuPont to evaluate the skin corrosion potential of a test substance, using a standardized assay to measure the time for the substance to penetrate a biobarrier membrane.
|
— |
AR226-3242
|
yr4MzdoNXpgY0LR9G6d41nGzr |
10 |
|
The document outlines a subchronic toxicity study conducted by DuPont on the test substance H-24678 (likely a perfluorinated compound) in rats over a 90-day oral gavage period, detailing the study design, dosages, and critical dates for administration and sacrifice of the test subjects.
|
— |
AR226-3245
|
1geaqv6gBXR86gJ6k6J1vYpba |
318 |
|
The document presents findings from a subchronic toxicity study conducted by DuPont on male rats, detailing various liver lesions associated with different doses of a substance, likely PFOA or a related perfluorinated compound, administered via oral gavage.
|
— |
AR226-3244
|
6BXYLNRd8djmma6xap8yZwGp6 |
274 |
|
The document reports on a study conducted by DuPont to determine the inhalation approximate lethal concentration (ALC) of a substance identified as H-25134 in male rats, indicating that the test substance was stable during the study.
|
— |
AR226-3247
|
RJkJXzgnxXab74rryQV3EnVY8 |
12 |
|
The document reports on a subchronic toxicity study of PFOA conducted by DuPont, detailing biochemical measurements of beta-oxidation rates in male rats over a 90-day oral gavage period.
|
— |
AR226-3246
|
71XqN7V4qYQegaGQpxZJDBvaB |
261 |